Travelling facts: a perspective from Indian agriculture

Studying the Tamil Nadu Precision Farming Project, Peter Howlett and Aashish Velkar find that technology transfer occurs when facts associated with the process travel well

Investigation of the flowfield induced by simulated battle damage

Particle Image Velocimetry (PIV) has been used to study the complex flowfield created by simulated battle damage to a two-dimensional wing. Computational Fluid Dynamics (CFD) predictions have also been used for validation of internal cavity flow. Two damage cases were selected for the study; both cases were simulated using a single hole with diameters equal to 20% and 40% of the chord, located at the wing half-chord. Wind tunnel tests were conducted at a Reynolds number of 500,000 over a range of incidences from 0 to 10◦ with two-component PIV measurements made on three chordwise and three spanwise planes. The PIV data were analysed and compared to CFD data of the same damage cases. The PIV data have shown lower velocity ratios and lower vorticity in the jet compared to past Jet in Cross-Flow experiments and CFD was used to describe the flow features inside the cavity of the wing. It was seen that the wing cavity has large effects on the external flow features, particularly for the 20% damage case. Finally, the flow field data have been related to force balance data. At higher incidence angles, the larger force coefficient increments in both lift and drag can be attributed to the larger wakes and higher jet strengths

Capturing the Daylight Dividend

Capturing the Daylight Dividend conducted activities to build market demand for daylight as a means of improving indoor environmental quality, overcoming technological barriers to effective daylighting, and informing and assisting state and regional market transformation and resource acquisition program implementation efforts. The program clarified the benefits of daylight by examining whole building systems energy interactions between windows, lighting, heating, and air conditioning in daylit buildings, and daylighting's effect on the human circadian system and productivity. The project undertook work to advance photosensors, dimming systems, and ballasts, and provided technical training in specifying and operating daylighting controls in buildings. Future daylighting work is recommended in metric development, technology development, testing, training, education, and outreach

An online toolbox for cover crops and living mulches

Cover crops and living mulches form an integral component of conservation agriculture promoting soil health and minimising external inputs. The OSCAR Project (Optimising Subsidiary Crop Applications in Rotation) aims to improve practices of conservation agriculture in farming systems across Europe. The principal output of the project is to develop a toolbox to make technical and scientific information publically available to farmers, researchers, and other stakeholders. The continually evolving toolbox is currently available online at www.covercrops.eu and will consist of three facets (1) An interactive user-fed wiki providing information on subsidiary crops species and machinery use with links to published literature. (2) A searchable database on subsidiary crops and technology. This will detail climatic and soil specific plant traits and will form a decision support tool to aid choices of subsidiary crops. (3) A discussion forum will also facilitate the exchange of information between farmers, researchers and stakeholders on conservation agricultural systems across European countries

Clinical Next-Generation Sequencing Pipeline Outperforms a Combined Approach Using Sanger Sequencing and Multiplex Ligation-Dependent Probe Amplification in Targeted Gene Panel Analysis

Advances in next-generation sequencing (NGS) have facilitated parallel analysis of multiple genes enabling the implementation of cost-effective, rapid, and high-throughput methods for the molecular diagnosis of multiple genetic conditions, including the identification of BRCA1 and BRCA2 mutations in high-risk patients for hereditary breast and ovarian cancer. We clinically validated a NGS pipeline designed to replace Sanger sequencing and multiplex ligation-dependent probe amplification analysis and to facilitate detection of sequence and copy number alterations in a single test focusing on a BRCA1/BRCA2 gene analysis panel. Our custom capture library covers 46 exons, including BRCA1 exons 2, 3, and 5 to 24 and BRCA2 exons 2 to 27, with 20 nucleotides of intronic regions both 5′ and 3′ of each exon. We analyzed 402 retrospective patients, with previous Sanger sequencing and multiplex ligation-dependent probe amplification results, and 240 clinical prospective patients. One-hundred eighty-three unique variants, including sequence and copy number variants, were detected in the retrospective (n = 95) and prospective (n = 88) cohorts. This standardized NGS pipeline demonstrated 100% sensitivity and 100% specificity, uniformity, and high-depth nucleotide coverage per sample (approximately 7000 reads per nucleotide). Subsequently, the NGS pipeline was applied to the analysis of larger gene panels, which have shown similar uniformity, sample-to-sample reproducibility in coverage distribution, and sensitivity and specificity for detection of sequence and copy number variants

Reforms: A Quest for Efficiency or an Opportunity for Vested Interests'? A Case Study of Pharmaceutical Policy Reforms in Tanzania.

Regulation of the pharmaceutical sector is a challenging task for most governments in the developing countries. In Tanzania, this task falls under the Food and Drugs Authority and the Pharmacy Council. In 2010, the Pharmacy Council spearheaded policy reforms in the pharmaceutical sector aimed at taking over the control of the regulation of the business of pharmacy from the Tanzania Food and Drugs Authority. This study provides a critical analysis of these reforms. The study employed a qualitative case-study design. Data was collected through in-depth interviews, focus group discussions and document reviews. Data was analyzed thematically using a policy triangle framework. The analysis was done manually. The reforms adopted an incremental model of public policy-making and the process was characterized by lobbying for political support, negotiations and bargaining between the interest groups. These negotiations were largely centred on vested interests and not on the impact of the reforms on the efficiency of pharmaceutical regulations in the country. Stakeholders from the micro and meso levels were minimally involved in the policy reforms. Recent pharmaceutical regulation reforms in Tanzania were overshadowed by vested interests, displacing a critical analysis of optimal policy options that have the potential to increase efficiency in the regulation of the business of pharmacy. Politics influenced decision-making at different levels of the reform process

Trapping and bypassing of suspended particulate matter, particulate nutrients and faecal indicator organisms in the river-estuary transition zone of a shallow macrotidal estuary

Hydrodynamic controls of the transport of suspended particulate matter (SPM), particulate nutrients and faecal indicator organisms (FIOs) in the river-estuary transition zone (RETZ) of a shallow macrotidal estuary were studied on tidal and seasonal timescales. The RETZ was found to be a conduit for SPM rather than a zone of particle accumulation during spring tides, with complex size fractionation and biogeochemical exchanges of particulate nutrient/FIO compositions. The downstream RETZ was characterised by flood-dominant currents, but with ebb-dominant turbulence due to the suppression of flood tide turbulence by salinity stratification created by lateral convergence; this produced a net seaward mass transport of SPM. Without lateral convergence in the narrower upstream RETZ, flood-dominant currents and flood-dominant turbulence were experienced. Hence the RETZ exported SPM landwards from its upper end and seawards from its lower end — a process observed throughout the year during spring tides and low-to-mean river flows. During neap tides when SPM concentrations were reduced, the RETZ became a zone of minor particle accumulation as its lower end imported SPM landwards from the estuary and its upper end imported SPM seawards from the river. During a river flood event, net SPM flux was significantly increased and was seawards throughout the RETZ. SPM mass concentration and carbon, nitrogen, phosphorous, and FIO concentrations peaked due to local resuspension and advection of an ephemeral estuarine turbidity maximum (ETM). The ETM formed on the advancing flood tide due to entrainment of material from intertidal flats. Flocculation and settling occurred at high slack water. The ETM was reconstituted by entrainment on the ebb and was composed of larger flocs than on the flood. Particulate nutrients and FIOs were associated with flocs in the 10–200 μm range but not with smaller or larger flocs. SPM concentrations in the resuspension component and ETM exceeded microbial water quality standards, emphasising the need for monitoring practices that consider tidal dynamics. The results from this study showing periodic SPM export from, rather than prolonged accumulation in, the RETZ and the influence of particle size fractionation on biogeochemical fluxes in the RETZ, are likely to be transferable to many other embayment-type estuaries on macrotidal coasts

Source apportionment of fine atmospheric particles in Bloemfontein, South Africa, using positive matrix factorization

DATA AVAILABILITY : Data generated or analysed during this study are included in this published article and its supplementary information file. Additional data are available from the corresponding author on reasonable request.Please read abstract in the article.The South African National Research Foundation, the Central Research Fund of the University of the Free State, Bloemfontein, and the University of Pretoria. Open access funding provided by University of Gothenburg.http://link.springer.com/journal/10661hj2024School of Health Systems and Public Health (SHSPH)SDG-06:Clean water and sanitationSDG-09: Industry, innovation and infrastructureSDG-11:Sustainable cities and communitie

Cannabinoid receptors in GtoPdb v.2023.1

Cannabinoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Cannabinoid Receptors [119]) are activated by endogenous ligands that include N-arachidonoylethanolamine (anandamide), N-homo-γ-linolenoylethanolamine, N-docosatetra-7,10,13,16-enoylethanolamine and 2-arachidonoylglycerol. Potency determinations of endogenous agonists at these receptors are complicated by the possibility of differential susceptibility of endogenous ligands to enzymatic conversion [5].There are currently three licenced cannabinoid medicines each of which contains a compound that can activate CB1 and CB2 receptors [111]. Two of these medicines were developed to suppress nausea and vomiting produced by chemotherapy. These are nabilone (Cesamet®), a synthetic CB1/CB2 receptor agonist, and synthetic Δ9-tetrahydrocannabinol (Marinol®; dronabinol), which can also be used as an appetite stimulant. The third medicine, Sativex®, contains mainly Δ9-tetrahydrocannabinol and cannabidiol, both extracted from cannabis, and is used to treat multiple sclerosis and cancer pain