The (Mis)appropriation of HIV/AIDS advocacy strategies in Global Mental Health: towards a more nuanced approach

Background: Mental health is increasingly finding a place on global health and international development agendas. Advocates for Global Mental Health (GMH), and international organizations such as the World Health Organization (WHO) and the World Bank, argue that treatments available in high-income countries should also be made available in low- and middle-income countries. Such arguments are often made by comparing mental health to infectious diseases, including the relative disease and economic burdens they impose, and pointing to the applicability of the right to access treatment for mental health, not only infectious diseases. HIV/AIDS advocacy in particular has been held up by GMH advocates as offering an appropriate strategy for generating global commitment. Discussion: There is a need to assess how health issues are framed not only in relation to social goods outside of health (such as human rights, security or development), but also in relation to other health or disease models, and how health policy and practice is shaped as a result. The article debates the merits and consequences of likening mental health to HIV/AIDS, and identifies four major problems with the model for GMH advocacy being developed through these analogies: 1. An inappropriately universalizing global approach to context-specific problems; 2. A conception of human rights that focuses on the right to access treatment at the expense of the right to refuse it; 3. A tendency to treat poverty as a psychiatric issue, rather than recognizing that mental distress can be the result of poverty and other forms of inequality; 4. The prioritization of destigmatization of disease over social justice models. Conclusion: There are significant problems with the wholesale adoption of an (often simplified) version of HIV/AIDS advocacy as a model for GMH. Yet critical engagement with the important and nuanced differences between HIV/AIDS and mental health may nevertheless point to some possibilities for productive engagement and cross-fertilisation between advocates, activists and scholars in both fields

'The risks of playing it safe': a prospective longitudinal study of response to reward in the adolescent offspring of depressed parents

BACKGROUND Alterations in reward processing may represent an early vulnerability factor for the development of depressive disorder. Depression in adults is associated with reward hyposensitivity and diminished reward seeking may also be a feature of depression in children and adolescents. We examined the role of reward responding in predicting depressive symptoms, functional impairment and new-onset depressive disorder over time in the adolescent offspring of depressed parents. In addition, we examined group differences in reward responding between currently depressed adolescents, psychiatric and healthy controls, and also cross-sectional associations between reward responding and measures of positive social/environmental functioning. Method We conducted a 1-year longitudinal study of adolescents at familial risk for depression (n = 197; age range 10-18 years). Reward responding and self-reported social/environmental functioning were assessed at baseline. Clinical interviews determined diagnostic status at baseline and at follow-up. Reports of depressive symptoms and functional impairment were also obtained. RESULTS Low reward seeking predicted depressive symptoms and new-onset depressive disorder at the 1-year follow-up in individuals free from depressive disorder at baseline, independently of baseline depressive symptoms. Reduced reward seeking also predicted functional impairment. Adolescents with current depressive disorder were less reward seeking (i.e. bet less at favourable odds) than adolescents free from psychopathology and those with externalizing disorders. Reward seeking showed positive associations with social and environmental functioning (extra-curricular activities, humour, friendships) and was negatively associated with anhedonia. There were no group differences in impulsivity, decision making or psychomotor slowing. CONCLUSIONS Reward seeking predicts depression severity and onset in adolescents at elevated risk of depression. Adaptive reward responses may be amenable to change through modification of existing preventive psychological interventions

A Search for Variable Stars and Planetary Occultations in NGC2301 I: Techniques

We observed the young open cluster NGC 2301 for 14 nights in Feb. 2004 using the orthogonal transfer CCD camera (OPTIC). We used PSF shaping techniques ("square stars") during the observations allowing a larger dynamic range (4.5 magnitudes) of high photometric precision results ($\le$2 mmag) to be obtained. These results are better than similar observing campaigns using standard CCD imagers. This paper discusses our observational techniques and presents initial results for the variability statistics found in NGC 2301. Details of the variability statistics as functions of color, variability type, stellar type, and cluster location will appear in paper II

Set-Based Concurrent Engineering Model for Automotive Electronic/Software Systems Development

Organised by: Cranfield UniversityThis paper is presenting a proposal of a novel approach to automotive electronic/software systems development. It is based on the combination of Set-Based Concurrent Engineering, a Toyota approach to product development, with the standard V-Model of software development. Automotive industry currently faces the problem of growing complexity of electronic/software systems. This issue is especially visible at the level of integration of these systems which is difficult and error-prone. The presented conceptual proposal is to establish better processes that could handle the electronic/software systems design and development in a more integrated and consistent manner.Mori Seiki – The Machine Tool Compan

Is there Evidence for a Hubble bubble? The Nature of Type Ia Supernova Colors and Dust in External Galaxies

We examine recent evidence from the luminosity-redshift relation of Type Ia Supernovae (SNe Ia) for the $\sim 3 \sigma$ detection of a ``Hubble bubble'' -- a departure of the local value of the Hubble constant from its globally averaged value \citep{Jha:07}. By comparing the MLCS2k2 fits used in that study to the results from other light-curve fitters applied to the same data, we demonstrate that this is related to the interpretation of SN color excesses (after correction for a light-curve shape-color relation) and the presence of a color gradient across the local sample. If the slope of the linear relation ($\beta$) between SN color excess and luminosity is fit empirically, then the bubble disappears. If, on the other hand, the color excess arises purely from Milky Way-like dust, then SN data clearly favors a Hubble bubble. We demonstrate that SN data give $\beta \simeq 2$, instead of the $\beta \simeq 4$ one would expect from purely Milky-Way-like dust. This suggests that either SN intrinsic colors are more complicated than can be described with a single light-curve shape parameter, or that dust around SN is unusual. Disentangling these possibilities is both a challenge and an opportunity for large-survey SN Ia cosmology.Comment: Further information and data at http://qold.astro.utoronto.ca/conley/bubble/ Accepted for publication in ApJ

Catching VY Sculptoris in a low state

Context. In the context of a large campaign to determine the system parameters of high mass transfer cataclysmic variables, we found VY Scl in a low state in 2008. Aims. Making use of this low state, we study the stellar components of the binary with little influence of the normally dominating accretion disc. Methods. Time-resolved spectroscopy and photometry of VY Scl taken during the low state are presented. We analysed the light-curve and radial velocity curve and use time-resolved spectroscopy to calculate Doppler maps of the dominant emission lines. Results. The spectra show narrow emission lines of Halpha, Hbeta, HeI, NaID, and FeII, as well as faint TiO absorption bands that trace the motion of the irradiated secondary star, and Halpha and HeI emission line wings that trace the motion of the white dwarf. From these radial velocities, we find an orbital period of 3.84 h, and put constraints on binary parameters such as the mass ratio M2/M1 of 0.43 and the inclination of 15 deg. With a secondary's mass between 0.3 and 0.35 Msol, we derive the mass for the white dwarf as M1 = 0.6-0.1 Msol.Comment: 8 pages, 9 figures, accepted for publication in A&