111 research outputs found
Flop Transitions in M-theory Cosmology
We study flop-transitions for M-theory on Calabi-Yau three-folds and their
applications to cosmology in the context of the effective five-dimensional
supergravity theory. In particular, the additional hypermultiplet which becomes
massless at the transition is included in the effective action. We find the
potential for this hypermultiplet which includes quadratic and quartic terms as
well as additional dependence on the Kahler moduli. By constructing explicit
cosmological solutions, it is demonstrated that a flop-transition can indeed by
achieved dynamically, as long as the hypermultiplet is set to zero. Once
excitations of the hypermultiplet are taken into account we find that the
transition is generically not completed but the system is stabilised close to
the transition region. Regions of moduli space close to flop-transitions can,
therefore, be viewed as preferred by the cosmological evolution.Comment: 18 pages, Latex, 8 eps-figures, typos correcte
The spinorial geometry of supersymmetric heterotic string backgrounds
We determine the geometry of supersymmetric heterotic string backgrounds for
which all parallel spinors with respect to the connection with
torsion , the NSNS three-form field strength, are Killing. We find
that there are two classes of such backgrounds, the null and the timelike. The
Killing spinors of the null backgrounds have stability subgroups
K\ltimes\bR^8 in , for , SU(4), , and , and the Killing spinors of the timelike backgrounds have
stability subgroups , SU(3), SU(2) and . The former admit a single
null -parallel vector field while the latter admit a timelike and
two, three, five and nine spacelike -parallel vector fields,
respectively. The spacetime of the null backgrounds is a Lorentzian
two-parameter family of Riemannian manifolds with skew-symmetric torsion.
If the rotation of the null vector field vanishes, the holonomy of the
connection with torsion of is contained in . The spacetime of time-like
backgrounds is a principal bundle with fibre a Lorentzian Lie group and
base space a suitable Riemannian manifold with skew-symmetric torsion. The
principal bundle is equipped with a connection which determines the
non-horizontal part of the spacetime metric and of . The curvature of
takes values in an appropriate Lie algebra constructed from that of
. In addition has only horizontal components and contains the
Pontrjagin class of . We have computed in all cases the Killing spinor
bilinears, expressed the fluxes in terms of the geometry and determine the
field equations that are implied by the Killing spinor equations.Comment: 73pp. v2: minor change
Global agricultural intensification during climate change: A role for genomics
Summary: Agriculture is now facing the 'perfect storm' of climate change, increasing costs of fertilizer and rising food demands from a larger and wealthier human population. These factors point to a global food deficit unless the efficiency and resilience of crop production is increased. The intensification of agriculture has focused on improving production under optimized conditions, with significant agronomic inputs. Furthermore, the intensive cultivation of a limited number of crops has drastically narrowed the number of plant species humans rely on. A new agricultural paradigm is required, reducing dependence on high inputs and increasing crop diversity, yield stability and environmental resilience. Genomics offers unprecedented opportunities to increase crop yield, quality and stability of production through advanced breeding strategies, enhancing the resilience of major crops to climate variability, and increasing the productivity and range of minor crops to diversify the food supply. Here we review the state of the art of genomic-assisted breeding for the most important staples that feed the world, and how to use and adapt such genomic tools to accelerate development of both major and minor crops with desired traits that enhance adaptation to, or mitigate the effects of climate change. >
Influence of Low-Degree High-Order p-Mode Splittings on the Solar Rotation Profile
The solar rotation profile is well constrained down to about 0.25 R thanks to
the study of acoustic modes. Since the radius of the inner turning point of a
resonant acoustic mode is inversely proportional to the ratio of its frequency
to its degree, only the low-degree p modes reach the core. The higher the order
of these modes, the deeper they penetrate into the Sun and thus they carry more
diagnostic information on the inner regions. Unfortunately, the estimates of
frequency splittings at high frequency from Sun-as-a-star measurements have
higher observational errors due to mode blending, resulting in weaker
constraints on the rotation profile in the inner core. Therefore inversions for
the solar internal rotation use only modes below 2.4 mHz for l < 4. In the work
presented here, we used an 11.5 year-long time series to compute the rotational
frequency splittings for modes l < 4 using velocities measured with the GOLF
instrument. We carried out a theoretical study of the influence of the
low-degree modes in the region 2 to 3.5 mHz on the inferred rotation profile as
a function of their error bars.Comment: Accepted for publication in Solar Physics. 17 Pages, 9 figure
Perspectives in Global Helioseismology, and the Road Ahead
We review the impact of global helioseismology on key questions concerning
the internal structure and dynamics of the Sun, and consider the exciting
challenges the field faces as it enters a fourth decade of science
exploitation. We do so with an eye on the past, looking at the perspectives
global helioseismology offered in its earlier phases, in particular the
mid-to-late 1970s and the 1980s. We look at how modern, higher-quality, longer
datasets coupled with new developments in analysis, have altered, refined, and
changed some of those perspectives, and opened others that were not previously
available for study. We finish by discussing outstanding challenges and
questions for the field.Comment: Invited review; to appear in Solar Physics (24 pages, 6 figures
The PASTIS trial: testing tadalafil for possible use in vascular cognitive impairment
Introduction: There are few randomized clinical trials in vascular cognitive impairment (VCI). This trial tested the hypothesis that the PDE5 inhibitor tadalafil, a widely used vasodilator, increases cerebral blood flow (CBF) in older people with symptomatic small vessel disease, the main cause of VCI. Methods: In a double‐blind, placebo‐controlled, cross‐over trial, participants received tadalafil (20 mg) and placebo on two visits ≥7 days apart (randomized to order of treatment). The primary endpoint, change in subcortical CBF, was measured by arterial spin labelling. Results: Tadalafil increased CBF non‐significantly in all subcortical areas (N = 55, age: 66.8 (8.6) years) with greatest treatment effect within white matter hyperintensities (+9.8%, P = .0960). There were incidental treatment effects on systolic and diastolic blood pressure (–7.8, –4.9 mmHg; P < .001). No serious adverse events were observed. Discussion: This trial did not identify a significant treatment effect of single‐administration tadalafil on subcortical CBF. To detect treatment effects may require different dosing regimens
Testing the cognitive effects of tadalafil. Neuropsychological secondary outcomes from the PASTIS trial
Cerebral small vessel disease (SVD) is a major cause of cognitive impairment in older people. As secondary endpoints in a phase-2 randomised clinical trial, we tested the effects of single administration of a widely-used PDE5 inhibitor, tadalafil, on cognitive performance in older people with SVD. In a double-blinded, placebo-controlled, cross-over trial, participants received tadalafil (20 mg) and placebo on two visits ≥ 7 days apart (randomised to order of treatment). The Montreal Cognitive Assessment (MOCA) was administered at baseline, alongside a measure to estimate optimal intellectual ability (Test of Premorbid Function). Then, before and after treatment, a battery of neuropsychological tests was administered, assessing aspects of attention, information processing speed, working memory and executive function. Sixty-five participants were recruited and 55 completed the protocol (N = 55, age: 66.8 (8.6) years, range 52–87; 15/40 female/male). Median MOCA score was 26 (IQR: 23, 27], range 15–30). No significant treatment effects were seen in any of the neuropsychological tests. There was a trend towards improved performance on Digit Span Forward (treatment effect 0.37, C.I. 0.01, 0.72; P = 0.0521). We did not identify significant treatment effects of single-administration tadalafil on neuropsychological performance in older people with SVD. The trend observed on Digit Span Forward may help to inform future studies
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