Jackson\u27s Flying Dutchmen: The Significance of the Royal Netherlands Military Flying School

From May 1942 thru February 1944, the United States allowed the Netherlands to train its aviators at Jackson Army Air Base. Known as the Royal Netherlands Military Flying School, the training the Dutch conducted helped rebuild the Royal Netherland Air Force and the air component of the Royal Netherland Navy. The Dutch military came to Jackson because they lost their territory to foreign invaders. Furthermore, the surviving members of the Dutch military felt compelled to endure and carry on the fight. The United States military selected Jackson Army Air Base because of its geographic location, the existing infrastructure at the base, and the support the community had for both the military and aviation. Once in Jackson, the instructors and students of the Royal Netherlands Military Flying School interacted with both the American military forces stationed at the base and the civilians living in Jackson. Through their interactions with the American military, the Dutch adopted a more methodical and scientific method to pilot training like theAmericans. While the Dutch military adopted several other American military traditions, they did not adopt them wholesale. The Dutch also interacted with the civilians of Jackson. The Dutch and Jacksonians interacted in a variety of ways displaying both the positive and negative aspects of both cultures. Ultimately the Dutch experience in Jackson was one of the first successful multinational training experiments in the U.S. The Dutch helped open the doors to the international training programs seen today

Laser-only adaptive optics achieves significant image quality gains compared to seeing-limited observations over the entire sky

Adaptive optics laser guide star systems perform atmospheric correction of stellar wavefronts in two parts: stellar tip-tilt and high-spatial-order laser-correction. The requirement of a sufficiently bright guide star in the field-of-view to correct tip-tilt limits sky coverage. Here we show an improvement to effective seeing without the need for nearby bright stars, enabling full sky coverage by performing only laser-assisted wavefront correction. We used Robo-AO, the first robotic AO system, to comprehensively demonstrate this laser-only correction. We analyze observations from four years of efficient robotic operation covering 15,000 targets and 42,000 observations, each realizing different seeing conditions. Using an autoguider (or a post-processing software equivalent) and the laser to improve effective seeing independent of the brightness of a target, Robo-AO observations show a 39+/-19% improvement to effective FWHM, without any tip-tilt correction. We also demonstrate that 50% encircled-energy performance without tip-tilt correction remains comparable to diffraction-limited, standard Robo-AO performance. Faint-target science programs primarily limited by 50% encircled-energy (e.g. those employing integral field spectrographs placed behind the AO system) may see significant benefits to sky coverage from employing laser-only AO.Comment: Accepted for publication in The Astronomical Journal. 7 pages, 6 figure

The Digital House of Care: information solutions for integrated care

Purpose – The purpose of this paper is to describe the development of a digital tool in an English county striving towards a vision of integrated information that is used to underpin an increasingly integrated future of health and social care delivery. Design/methodology/approach – It discusses the policy context nationally, the origins and implementation of the initiative, the authors’ experiences and viewpoint highlighting key challenges and learning, as well as examples of new work undertaken. Findings – In all, 12 health and care organisations have participated in this project. The ability for local commissioners and providers of services to now understand “flow” both between and within services at a granular level is unique. Costs are modest, and the opportunities for refining and better targeting as well as validating services are significant, thus demonstrating a return on investment. Key learning includes how organisational development was equally as important as the implementation of innovative new software, that change management from grass roots to strategic leaders is vital, and that the whole system is greater than the sum of its otherwise in-silo parts. Practical implications – Data linkage initiatives, whether local, regional or national in scale, need to be programme managed. A robust governance and accountability framework must be in place to realise the benefits of such as a solution, and IT infrastructure is paramount. Social implications – Organisational development, collaborative as well as distributed leadership, and managing a change in culture towards health and care information is critical in order to create a supportive environment that fosters learning across organisational boundaries. Originality/value – This paper draws on the recent experience of achieving large-scale data integration across the boundaries of health and social care, to help plan and commission services more effectively. This rich, multi-agency intelligence has already begun to change the way in which the system considers service planning, and learning from this county’s approach may assist others considering similar initiatives.N/

Analyzing the Effects of E-hook Peptides on Kinesin-1

Cancer is the second leading cause of death in the United States. Cancerous growth is a result of oncogenes, or mutated genes that increase the rate of cell division in an uncontrolled manner. Cell division, which consists of mitosis and cytokinesis phases, is dependent upon the active movement of kinesin motor proteins along microtubules to rearrange the cytoskeleton for equitable distribution of genetic material to daughter cells. As kinesins are vital to this process, if we could prevent kinesin from binding to the microtubules, cell division would cease. The goal of this study is to develop a method to prevent cell division by targeting and disrupting kinesin’s microtubule binding sites to prevent them from generating the necessary forces to foster cell growth. The “walking” of the kinesin on microtubules is facilitated by a series of negatively charged residues in the carboxy terminal tail of tubulin known as E-hooks. The processivity of kinesin motor proteins is strongly reduced if E- hooks have been removed from the microtubule surface. It is thought that this is because the E-hooks’ negative charges interact with positively charged domains of the kinesin motor domain. Therefore, we hypothesize that similarly structured, negatively charged peptides could be used to saturate kinesin’s binding sites. We found that a short E-hook like peptide inhibited kinesin-1 resulting in a decrease in force generated; however, there was minimal effect on velocity. Kinesin-5 is less processive and generates weaker forces than kinesin-1; thus we propose that this effect will be amplified in kinesin-5 and other mitotic kinesin. We hypothesize that inhibiting these motors that play a vital role in mitosis will stop cell division and halt cancerous growth

Collegial Feedback: Navigating the Obstacles

The purpose of this PLM is to provide a conceptual framework for effective collegial feedback and to enhance the educational process. It was devised to empower individuals through building capacity in identifying possible obstacles to effective collegial feedback and to acquaint individuals with resources and strategies to overcome obstacles in collegial feedback. This PLM was designed for educators who have to provide feedback, including mentors, instructional coaches, and peer observers. Because it aligns with the adult learners’ ways of knowing, it is geared toward those who give feedback to adults rather than K-12 students. View professional learning module.https://digitalcommons.gardner-webb.edu/improve/1024/thumbnail.jp

Tests of pattern separation and pattern completion in humans - a systematic review

OBJECTIVE: To systematically review the characteristics, validity and outcome measures of tasks that have been described in the literature as assessing pattern separation and pattern completion in humans. METHODS: Electronic databases were searched for articles. Parameters for task validity were obtained from two reviews that described optimal task design factors to evaluate pattern separation and pattern completion processes. These were that pattern separation should be tested during an encoding task using abstract, never-before-seen visual stimuli, and pattern completion during a retrieval task using partial cues; parametric alteration of the degree of interference of stimuli or degradation of cues should be used to generate a corresponding gradient in behavioral output; studies should explicitly identify the specific memory domain under investigation (sensory/perceptual, temporal, spatial, affect, response, or language) and account for the contribution of other potential attributes involved in performance of the task. A systematic, qualitative assessment of validity in relation to these parameters was performed, along with a review of general validity and task outcome measures. RESULTS: Sixty-two studies were included. The majority of studies investigated pattern separation and most tasks were performed on young, healthy adults. Pattern separation and pattern completion were most frequently tested during a retrieval task using familiar or recognizable visual stimuli and cues. Not all studies parametrically altered the degree of stimulus interference or cue degradation, or controlled for potential confounding factors. CONCLUSION: This review found evidence that some of the parameters for task validity have been followed in some human studies of pattern separation and pattern completion, but no study was judged to have adequately met all the parameters for task validity. The contribution of these parameters and other task design factors towards an optimal behavioral paradigm is discussed and recommendations for future research are made. This article is protected by copyright. All rights reserved

Building the Evryscope: Hardware Design and Performance

The Evryscope is a telescope array designed to open a new parameter space in optical astronomy, detecting short timescale events across extremely large sky areas simultaneously. The system consists of a 780 MPix 22-camera array with an 8150 sq. deg. field of view, 13" per pixel sampling, and the ability to detect objects down to Mg=16 in each 2 minute dark-sky exposure. The Evryscope, covering 18,400 sq.deg. with hours of high-cadence exposure time each night, is designed to find the rare events that require all-sky monitoring, including transiting exoplanets around exotic stars like white dwarfs and hot subdwarfs, stellar activity of all types within our galaxy, nearby supernovae, and other transient events such as gamma ray bursts and gravitational-wave electromagnetic counterparts. The system averages 5000 images per night with ~300,000 sources per image, and to date has taken over 3.0M images, totaling 250TB of raw data. The resulting light curve database has light curves for 9.3M targets, averaging 32,600 epochs per target through 2018. This paper summarizes the hardware and performance of the Evryscope, including the lessons learned during telescope design, electronics design, a procedure for the precision polar alignment of mounts for Evryscope-like systems, robotic control and operations, and safety and performance-optimization systems. We measure the on-sky performance of the Evryscope, discuss its data-analysis pipelines, and present some example variable star and eclipsing binary discoveries from the telescope. We also discuss new discoveries of very rare objects including 2 hot subdwarf eclipsing binaries with late M-dwarf secondaries (HW Vir systems), 2 white dwarf / hot subdwarf short-period binaries, and 4 hot subdwarf reflection binaries. We conclude with the status of our transit surveys, M-dwarf flare survey, and transient detection.Comment: 24 pages, 24 figures, accepted PAS

Protoplanetary Disk Resonances and Type I Migration

Waves reflected by the inner edge of a protoplanetary disk are shown to significantly modify Type I migration, even allowing the trapping of planets near the inner disk edge for small planets in a range of disk parameters. This may inform the distribution planets close to their central stars, as observed by the Kepler mission.Comment: 6 pages, 3 figures, accepted by Ap