2,648 research outputs found
Heterogeneous multithreaded computing
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.by Howard J. LuM.Eng
K2-231 b: A sub-Neptune exoplanet transiting a solar twin in Ruprecht 147
We identify a sub-Neptune exoplanet ( R)
transiting a solar twin in the Ruprecht 147 star cluster (3 Gyr, 300 pc, [Fe/H]
= +0.1 dex). The ~81 day light curve for EPIC 219800881 (V = 12.71) from K2
Campaign 7 shows six transits with a period of 13.84 days, a depth of ~0.06%,
and a duration of ~4 hours. Based on our analysis of high-resolution MIKE
spectra, broadband optical and NIR photometry, the cluster parallax and
interstellar reddening, and isochrone models from PARSEC, Dartmouth, and MIST,
we estimate the following properties for the host star: M, R, and K. This star appears to be single, based on our modeling of the
photometry, the low radial velocity variability measured over nearly ten years,
and Keck/NIRC2 adaptive optics imaging and aperture-masking interferometry.
Applying a probabilistic mass-radius relation, we estimate that the mass of
this planet is M, which would cause a RV
semi-amplitude of m s that may be measurable with existing
precise RV facilities. After statistically validating this planet with BLENDER,
we now designate it K2-231 b, making it the second sub-stellar object to be
discovered in Ruprecht 147 and the first planet; it joins the small but growing
ranks of 23 other planets found in open clusters.Comment: 24 pages, 7 figures, light curve included as separate fil
Single-cell epigenomic variability reveals functional cancer heterogeneity.
BackgroundCell-to-cell heterogeneity is a major driver of cancer evolution, progression, and emergence of drug resistance. Epigenomic variation at the single-cell level can rapidly create cancer heterogeneity but is difficult to detect and assess functionally.ResultsWe develop a strategy to bridge the gap between measurement and function in single-cell epigenomics. Using single-cell chromatin accessibility and RNA-seq data in K562 leukemic cells, we identify the cell surface marker CD24 as co-varying with chromatin accessibility changes linked to GATA transcription factors in single cells. Fluorescence-activated cell sorting of CD24 high versus low cells prospectively isolated GATA1 and GATA2 high versus low cells. GATA high versus low cells express differential gene regulatory networks, differential sensitivity to the drug imatinib mesylate, and differential self-renewal capacity. Lineage tracing experiments show that GATA/CD24hi cells have the capability to rapidly reconstitute the heterogeneity within the entire starting population, suggesting that GATA expression levels drive a phenotypically relevant source of epigenomic plasticity.ConclusionSingle-cell chromatin accessibility can guide prospective characterization of cancer heterogeneity. Epigenomic subpopulations in cancer impact drug sensitivity and the clonal dynamics of cancer evolution
KELT-4Ab: An inflated Hot Jupiter transiting the bright (V~10) component of a hierarchical triple
We report the discovery of KELT-4Ab, an inflated, transiting Hot Jupiter orbiting the brightest component of a hierarchical triple stellar system. The host star is an F star with T_(eff) = 6206 ± 75 K, log g = 4.108 ± 0.014, [Fe/H] = -0.116_(-0.069)^(+0.065, M_* = 1.201_(-0.061)^(+0.067) M_☉, and R_* = 1.603_(-0.038)^(+0.039) R_☉. The best-fit linear ephemeris is BJD_(TDB); = 2456193.29157 ± 0.00021 + E(2.9895936 ± 0.0000048). With a magnitude of V ~ 10, a planetary radius of 1.699_(-0.045)^(+0.046); R_J, and a mass of 0.902_(-0.059)^(+0.060) M_J, it is the brightest host among the population of inflated Hot Jupiters (R_P > 1.5 R_J), making it a valuable discovery for probing the nature of inflated planets. In addition, its existence within a hierarchical triple and its proximity to Earth (210 pc) provide a unique opportunity for dynamical studies with continued monitoring with high resolution imaging and precision radial velocities. The projected separation between KELT-4A and KELT-4BC is 328 ± 16 AU and the projected separation between KELT-4B and KELT-4C is 10.30 ± 0.74 AU. Assuming face-on, circular orbits, their respective periods would be 3780 ± 290 and 29.4 ± 3.6 years and the astrometric motions relative to the epoch in this work of both the binary stars around each other and of the binary around the primary star would be detectable now and may provide meaningful constraints on the dynamics of the system
An Empirically Derived Three-Dimensional Laplace Resonance in the Gliese 876 Planetary System
We report constraints on the three-dimensional orbital architecture for all
four planets known to orbit the nearby M dwarf Gliese 876 based solely on
Doppler measurements and demanding long-term orbital stability. Our dataset
incorporates publicly available radial velocities taken with the ELODIE and
CORALIE spectrographs, HARPS, and Keck HIRES as well as previously unpublished
HIRES velocities. We first quantitatively assess the validity of the planets
thought to orbit GJ 876 by computing the Bayes factors for a variety of
different coplanar models using an importance sampling algorithm. We find that
a four-planet model is preferred over a three-planet model. Next, we apply a
Newtonian MCMC algorithm to perform a Bayesian analysis of the planet masses
and orbits using an n-body model in three-dimensional space. Based on the
radial velocities alone, we find that a 99% credible interval provides upper
limits on the mutual inclinations for the three resonant planets
( for the "c" and "b" pair and for
the "b" and "e" pair). Subsequent dynamical integrations of our posterior
sample find that the GJ 876 planets must be roughly coplanar
( and ), suggesting the amount of
planet-planet scattering in the system has been low. We investigate the
distribution of the respective resonant arguments of each planet pair and find
that at least one argument for each planet pair and the Laplace argument
librate. The libration amplitudes in our three-dimensional orbital model
supports the idea of the outer-three planets having undergone significant past
disk migration.Comment: 19 pages, 11 figures, 8 tables. Accepted to MNRAS. Posterior samples
available at https://github.com/benelson/GJ87
The 55 Cancri Planetary System: Fully Self-Consistent N-body Constraints and a Dynamical Analysis
We present an updated study of the planets known to orbit 55 Cancri A using
1,418 high-precision radial velocity observations from four observatories
(Lick, Keck, Hobby-Eberly Telescope, Harlan J. Smith Telescope) and transit
time/durations for the inner-most planet, 55 Cancri "e" (Winn et al. 2011). We
provide the first posterior sample for the masses and orbital parameters based
on self-consistent n-body orbital solutions for the 55 Cancri planets, all of
which are dynamically stable (for at least years). We apply a GPU
version of Radial velocity Using N-body Differential evolution Markov Chain
Monte Carlo (RUN DMC; B. Nelson et al. 2014) to perform a Bayesian analysis of
the radial velocity and transit observations. Each of the planets in this
remarkable system has unique characteristics. Our investigation of high-cadence
radial velocities and priors based on space-based photometry yields an updated
mass estimate for planet "e" ( M), which affects its
density ( g cm) and inferred bulk composition.
Dynamical stability dictates that the orbital plane of planet "e" must be
aligned to within of the orbital plane of the outer planets (which we
assume to be coplanar). The mutual interactions between the planets "b" and "c"
may develop an apsidal lock about . We find 36-45% of all our model
systems librate about the anti-aligned configuration with an amplitude of
. Other cases showed short-term perturbations in the
libration of , circulation, and nodding, but we find the
planets are not in a 3:1 mean-motion resonance. A revised orbital period and
eccentricity for planet "d" pushes it further toward the closest known Jupiter
analog in the exoplanet population.Comment: 12 pages, 5 figures, 4 tables, accepted to MNRAS. Figure 2 (left) is
updated from published version. Posterior samples available at
http://www.personal.psu.edu/ben125/Downloads.htm
An Eccentric Hot Jupiter Orbiting the Subgiant HD 185269
We report the detection of a Jupiter-mass planet in a 6.838 day orbit around
the 1.28 solar mass subgiant HD 185269. The eccentricity of HD 185269b (e =
0.30) is unusually large compared to other planets within 0.1 AU of their
stars. Photometric observations demonstrate that the star is constant to
+/-0.0001 mag on the radial velocity period, strengthening our interpretation
of a planetary companion. This planet was detected as part of our radial
velocity survey of evolved stars located on the subgiant branch of the H-R
diagram--also known as the Hertzsprung Gap. These stars, which have masses
between 1.2 and 2.5 solar masses, play an important role in the investigation
of the frequency of extrasolar planets as a function of stellar mass.Comment: 18 pages, 4 figures, 3 tables, ApJ in press (scheduled for Dec 2006,
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