Set-Oriented Mining for Association Rules in Relational Databases

Describe set-oriented algorithms for mining association rules. Such algorithms imply performing multiple joins and may appear to be inherently less efficient than special-purpose algorithms. We develop new algorithms that can be expressed as SQL queries, and discuss the optimization of these algorithms. After analytical evaluation, an algorithm named SETM emerges as the algorithm of choice. SETM uses only simple database primitives, viz. sorting and merge-scan join. SETM is simple, fast and stable over the range of parameter values. The major contribution of this paper is that it shows that at least some aspects of data mining can be carried out by using general query languages such as SQL, rather than by developing specialized black-box algorithms. The set-oriented nature of SETM facilitates the development of extension

Visible light emission from reverse-biased silicon nanometer-scale diode-antifuses

Silicon nanometer-scale diodes have been fabricated to emit light in the visible range at low power consumption. Such structures are candidates for emitter elements in Si-based optical interconnect schemes. Spectral measurements of Electroluminescence (EL) on the reverse-biased nanometer-scale diodes brought into breakdown have been carried out over the photon energy range of 1.4-2.8 eV. Previously proposed mechanisms for avalanche emission from conventional silicon p-n junctions are discussed in order to understand the origin of the emission. Also the stability of the diodes has been tested. Results indicate that our nanometer-scale diodes are basically high quality devices. Furthermore due to the nanometer-scale dimensions, very high electrical fields and current densities are possible at low power consumption. This makes these diodes an excellent candidate to be utilized as a light source in Si-based sensors and actuator application

Bit-rate saving in multichannel sound:using a band-limited channel to transmit the center signal

A method is proposed to achieve full-frequency-range three-channel (left, right, and center) sound reproduction in systems that have only two full-range sound channels and some band-limited commentary channels. The low-frequency part of the center signal, which matches the bandwidth of the commentary channels, is added to the (multilingual) speech signals in each of the commentary channels. The remaining high-frequency part is added in the left and right channels as in conventional mixdowns. Sound reproduction of this signal by a conventional two-channel receiver remains unaltered. The low-frequency part of the center signal is mixed to the left and right signals together with the speech once the user has selected a commentary channel. Three-channel reproduction is obtained by routing the selected commentary channel to a central loudspeaker. Listening tests revealed that sound reproduction according to the proposed scheme could not be distinguished from original three-channel reproduction. This scheme can be applied to proposed standards such as D2MAC and MPEG2.</p

Communications Biophysics

Contains reports on three research projects.National Institutes of Health (Grant 5 PO1 GM14940-04)National Aeronautics and Space Administration (Grant NGL 22-009-304

Nonlinear Dynamics of the Perceived Pitch of Complex Sounds

We apply results from nonlinear dynamics to an old problem in acoustical physics: the mechanism of the perception of the pitch of sounds, especially the sounds known as complex tones that are important for music and speech intelligibility

Children's game library as a Unique Extracurricular Educational Establishment in the USSR (the middle of the 20th century)

The article reveals the history of emergence and work of children's game libraries in the USSR in the middle of the 20th century. The first children's game libraries, which were educational establishments where children could come and play different games, using various game and sport equipment free of charge, appeared in the 1930th and became wide spread in the USSR in the 1930th - 1950th. Children's game libraries had different tasks of their work (organizing children's cultural leisure time, increasing the educational and political levels of children's games and entertainments which were conducted in schools, summer camps and extracurricular educational establishments). They also had different directions of their work, namely: organizational, methodic, educational, experimental, instructive and consultative directions. It has been shown in the article that children’s game libraries had great results of their work (they involved a lot of children and adults in their activities; the network of children's game libraries began to grow; a lot of new toys and games were created and produced by them). However, children's game libraries faced certain difficulties in their work, namely: absence of own premises of children’s game libraries, lack of enough support for their activities by some educational institutions and teaching staff, lack of the required amount of toys and games, insufficient instructive and publishing activities of children’s game libraries

Communications Biophysics

COntains reports on six research projects.National Institutes of Health (Grant 2 P01 MH-04737-06)National Institutes of Health (Grant 5 ROl NB-05462-02)Joint Services Electronics Programs (U. S. Army, U. S. Navy, and U. S. Air Force) under Contract DA 36-039-AMC-03200(E)National Science Foundation (Grant GK-835)National Aeronautics and Space Administration (Grant NsG-496

Low preoperative skeletal muscle density is predictive for negative postoperative outcomes in older women with ovarian cancer

Objective. To determine the predictive value of lumbar skeletal muscle mass and density for postoperative outcomes in older women with advanced stage ovarian cancer.Methods. A multicenter, retrospective cohort study was performed in women >= 70 years old receiving surgery for primary, advanced stage ovarian cancer. Skeletal muscle mass and density were assessed in axial CT slices on level L3. Low skeletal muscle mass was defined as skeletal muscle index = 2).Conclusion. Low skeletal muscle density, as a proxy of muscle quality, is associated with poor postoperative outcomes in older patients with advanced stage ovarian cancer. These findings can contribute to postoperative risk assessment and clinical decision making. (C) 2021 The Author(s). Published by Elsevier Inc.Cervix cance

Communications Biophysics

Contains research objectives, summary of research and reports on two research project.National Institutes of Health (Grant 5 PO1 GM14940-03)National Institutes of Health (Grant 5 TO1 GM01555-03)National Aeronautics and Space Administration (Grant NGL 22-009-304

Real-world Data of Nivolumab for Patients With Advanced Renal Cell Carcinoma in the Netherlands:An Analysis of Toxicity, Efficacy, and Predictive Markers

Background: Nivolumab, a programmed death 1 inhibitor, has been approved as second-line treatment for advanced renal cell carcinoma (RCC) in Europe since 2016. We investigated the toxicity and efficacy of nivolumab as well as potential predictive biomarkers in the Dutch population. Patients and Methods: This was a retrospective, multicenter study of the Dutch national registry of nivolumab for the treatment of advanced RCC. The main outcome parameters included toxicity, objective response rate (ORR), overall survival (OS), progression-free survival (PFS), time to progression (TTP), and time to treatment failure (TTF). In addition, potential predictive and prognostic biomarkers for outcomes were evaluated. Results: Data on 264 patients were available, of whom 42% were International Metastatic RCC Database Consortium (IMDC) poor risk at start of nivolumab, 16% had ≥ 3 lines of previous therapy, 7% had non–clear-cell RCC, 11% had brain metastases, and 20% were previously treated with everolimus. Grade 3/4 immune-related adverse events occurred in 15% of patients. The median OS was 18.7 months (95% confidence interval, 13.7-23.7 months). Progression occurred in 170 (64.4%) of 264 patients, with a 6-and 12-months TTP of 49.8% and 31.1%, respectively. The ORR was 18.6% (49 of 264; 95% confidence interval, 14%-23%). Elevated baseline lymphocytes were associated with improved PFS (P =.038) and elevated baseline lactate dehydrogenase with poor OS, PFS, and TTF (P =.000). On-treatment increase in eosinophils by week 8 predicted improved OS (P =.003), PFS (P =.000), and TTF (P =.014), whereas a decrease of neutrophils was associated with significantly better TTF (P =.023). Conclusions: The toxicity and efficacy of nivolumab for metastatic RCC after previous lines of therapy are comparable with the results in the pivotal phase III trial and other real-world data. On-treatment increase in eosinophil count is a potential biomarker for efficacy and warrants further investigation