The Retinal Microvasculature in Secondary Progressive Multiple Sclerosis

In light of new data regarding pathology of multiple sclerosis (MS), more research is needed into the vascular aspects of the disease. Demyelination caused by inflammation is historically thought of as the main cause of disability in the disease. Recent studies, however, have suggested that MS is in fact a spectrum of overlapping phenotypes consisting of inflammation, oxidative damage and hypoperfusion. The microvasculature plays an important role in all of these pathogenic processes and its dysfunction may therefore be of crucial importance to the development and progression of the disease. This thesis focuses on investigating the microvasculature of the retina as a surrogate for the brain by assessing the vascular structure, blood flow dynamics and oxygen transfer of the retinal blood vessels in secondary progressive multiple sclerosis (SPMS). Studying the retinal microvasculature using a multimodal imaging approach has allowed us to develop a more detailed understanding of blood flow in MS and to identify new imaging markers for trials into neuroprotective drugs in MS. The work done in this thesis demonstrated; i) a higher rate of retinal microvascular abnormalities in MS which progresses with disease severity, ii) evidence of retinal vascular remodelling in SPMS and iii) changes in blood velocity and flow in the retina in SPMS. These observations pave the way for future investigations into the mechanisms of vascular alterations and vascular dysfunction in MS, and provide a set of imaging markers to further explore other cerebrovascular diseases through the retina

Douglas Coupland: Text as Art

This thesis discusses the art of contemporary Canadian artist Douglas Coupland and his use of textual art. It will explore his combinations of text and art through four major themes that are recurrent in both his writings and visual art: abundance, advertising, technology and translation and draw conclusions on the various reasons that text has become such an important component of his body of work. Overall, the thesis seeks to show Coupland’s unique use of text to create a modern take on Pop art that is able to highlight issues in society

Healthy happy family eating: development and feasibility of an online intervention to improve family eating behaviours

Unhealthy eating in children is a global problem, associated with poor long-term health outcomes and evidence indicates that unhealthy eating habits developed early in life may track into adulthood. Increasingly, description of behaviour change intervention development is encouraged. This paper describes the development and refinement of an online intervention designed to improve family eating behaviours. Part 1 describes three pilot studies designed to collect quantitative and qualitative feedback about the intervention to inform its development. This is followed by Part 2, which describes an additional study covering other formative work involved in developing the intervention, including theoretical approaches, evidence-base review and stakeholder input. The resulting, robustly refined intervention is described, the efficacy of which is being evaluated by a randomised controlled trial

Healthy eating interventions delivered in the family home: a systematic review

Unhealthy eating habits have long term health implications and can begin at a young age when children still consume the majority of their meals at home. As parents are the principal agents of change in children’s eating behaviours, the home environment is the logical location for the delivery of interventions targeting healthy family eating. Despite the recent proliferation of published studies of behaviour-change interventions delivered in the home, there has been little attempt to evaluate what makes such interventions successful. This review provides a systematic evaluation of all healthy eating interventions delivered to families in the home environment to date and seeks to identify the successful elements of these interventions and make recommendations for future work. Thirty nine studies are described, evaluated and synthesised. Results show that evidence- and theory-based interventions tended to be more successful than those that did not report detailed formative or evaluative work although details of theory application were often lacking. Careful analysis of the results did not show any further systematic similarities shared by successful interventions. Recommendations include the need for more clearly theoretically driven interventions, consistent approaches to measuring outcomes and clarity regarding target populations and desired outcomes

(32)P in the treatment of myeloproliferative disorders

(32)P has been available for the treatment of myeloproliferative neoplasms (MPNs) for over seventy years. It was first used in 1938 by John H Lawrence in the treatment of polycythaemia and chronic leukaemias. With the introduction of agents such as hydroxycarbamide, interferon and anagrelide the role of (32)P has been diminished. Today, Polycythaemia Rubra Vera (PRV) and Essential Thrombocythaemia (ET) remain the only myeloproliferative conditions in which (32)P is indicated. MATERIALS AND METHODS: We carried out a retrospective review of all patients who had received 32P in Northern Ireland over a 24 year period. The time to successful response, duration of response, and associated complications were reviewed. RESULTS: (32)P was successful in inducing remission in 90% of patients. This remission was sustained following one dose without the need for further therapy in 37% of cases. 47% required repeated doses. 26% required recommencement of alternative therapies. No cases of thrombosis, myelofibrosis or acute leukaemia were observed. DISCUSSION: We conclude that (32)P is a well-tolerated and efficacious treatment option in the elderly. We discuss our results compared with previous work in this area. (32)P will continue to be offered to elderly patients in our practice

Gibbs Phenomena for LqL^q-Best Approximation in Finite Element Spaces -- Some Examples

Recent developments in the context of minimum residual finite element methods are paving the way for designing finite element methods in non-standard function spaces. This, in particular, permits the selection of a solution space in which the best approximation of the solution has desirable properties. One of the biggest challenges in designing finite element methods are non-physical oscillations near thin layers and jump discontinuities. In this article we investigate Gibbs phenomena in the context of $L^q$-best approximation of discontinuities in finite element spaces with $1\leq q<\infty$. Using carefully selected examples, we show that on certain meshes the Gibbs phenomenon can be eliminated in the limit as $q$ tends to $1$. The aim here is to show the potential of $L^1$ as a solution space in connection with suitably designed meshes

Eliminating Gibbs Phenomena: A Non-linear Petrov-Galerkin Method for the Convection-Diffusion-Reaction Equation

In this article we consider the numerical approximation of the convection-diffusion-reaction equation. One of the main challenges of designing a numerical method for this problem is that boundary layers occurring in the convection-dominated case can lead to non-physical oscillations in the numerical approximation, often referred to as Gibbs phenomena. The idea of this article is to consider the approximation problem as a residual minimization in dual norms in Lq-type Sobolev spaces, with 1 < q < $\infty$. We then apply a non-standard, non-linear PetrovGalerkin discretization, that is applicable to reflexive Banach spaces such that the space itself and its dual are strictly convex. Similar to discontinuous Petrov-Galerkin methods, this method is based on minimizing the residual in a dual norm. Replacing the intractable dual norm by a suitable discrete dual norm gives rise to a non-linear inexact mixed method. This generalizes the Petrov-Galerkin framework developed in the context of discontinuous Petrov-Galerkin methods to more general Banach spaces. For the convection-diffusion-reaction equation, this yields a generalization of a similar approach from the L2-setting to the Lq-setting. A key advantage of considering a more general Banach space setting is that, in certain cases, the oscillations in the numerical approximation vanish as q tends to 1, as we will demonstrate using a few simple numerical examples

Experiences' of Health science students' in relation to the use of laboratory animals for experimental research purposes : a phenomenological inquiry.

M. Soc. Sc. University of KwaZulu-Natal, Durban 2014.The use of laboratory animals for research purposes has been debated for many years. Animal rights movements are strongly opposed to using animals for research purposes. There is also an argument that animal research is fundamental in the medical field to improve medical procedures and to develop new medical methods and treatments. Previous studies have primarily focused on issues of an ethical and moral nature regarding animal treatment, or on veterinarian sciences and animal shelter workers experiences. To my knowledge there is limited research focusing on postgraduate students’ experience and this research aims to address the gap. The study aims to explore the experiences of novice postgraduate research students using laboratory animals for their research and the influence of these experiences on their understanding of animal research and their psychological challenges. A qualitative approach was adopted using phenomenology as a framework and theory. Van Kaam’s descriptive phenomenological analysis was used to analyse eight email facilitated questionnaires completed by postgraduate students studying at the University of KwaZulu-Natal (UKZN) Biomedical Research Unit. The themes that emerged were: The moral dilemma; the experience of guilt; role expectation to improve quality of human life; deterrents factors to the animal experience; coping strategies and beliefs about the BRU education programme. The findings revealed participates faced several challenges linked to conducting research on animals in terms of under-preparedness, emotional well-being and moral stressors. Recommendations include for more effective preparation methods and practice for students using animals for research purposes and to implement psychological services to assist those students experiencing difficulties due to the research process.Date on print copy is 2014

Heart Rate Variability in Response to a 3-day Kumbhaka Pranayama Practice

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