A modified particle method for semilinear hyperbolic systems with oscillatory solutions

We introduce a modified particle method for semi-linear hyperbolic systems with highly oscillatory solutions. The main feature of this modified particle method is that we do not require different families of characteristics to meet at one point. In the modified particle method, we update the ith component of the solution along its own characteristics, and interpolate the other components of the solution from their own characteristic points to the ith characteristic point. We prove the convergence of the modified particle method essentially independent of the small scale for the variable coefficient Carleman model. The same result also applies to the non-resonant Broadwell model. Numerical evidence suggests that the modified particle method also converges essentially independent of the small scale for the original Broadwell model if a cubic spline interpolation is used

Second-Order Convergence of a Projection Scheme for the Incompressible Navier–Stokes Equations with Boundaries

A rigorous convergence result is given for a projection scheme for the Navies–Stokes equations in the presence of boundaries. The numerical scheme is based on a finite-difference approximation, and the pressure is chosen so that the computed velocity satisfies a discrete divergence-free condition. This choice for the pressure and the particular way that the discrete divergence is calculated near the boundary permit the error in the pressure to be controlled and the second-order convergence in the velocity and the pressure to the exact solution to be shown. Some simplifications in the calculation of the pressure in the case without boundaries are also discussed

Convergence of a nonconforming multiscale finite element method

The multiscale finite element method (MsFEM) [T. Y. Hou, X. H. Wu, and Z. Cai, Math. Comp., 1998, to appear; T. Y. Hou and X. H. Wu, J. Comput. Phys., 134 (1997), pp. 169-189] has been introduced to capture the large scale solutions of elliptic equations with highly oscillatory coefficients. This is accomplished by constructing the multiscale base functions from the local solutions of the elliptic operator. Our previous study reveals that the leading order error in this approach is caused by the "resonant sampling," which leads to large error when the mesh size is close to the small scale of the continuous problem. Similar difficulty also arises in numerical upscaling methods. An oversampling technique has been introduced to alleviate this difficulty [T. Y. Hou and X. H. Wu, J. Comput. Phys., 134 (1997), pp. 169-189]. A consequence of the oversampling method is that the resulting finite element method is no longer conforming. Here we give a detailed analysis of the nonconforming error. Our analysis also reveals a new cell resonance error which is caused by the mismatch between the mesh size and the wavelength of the small scale. We show that the cell resonance error is of lower order. Our numerical experiments demonstrate that the cell resonance error is generically small and is difficult to observe in practice

Eigenvalues of Ruijsenaars-Schneider models associated with An−1A_{n-1} root system in Bethe ansatz formalism

Ruijsenaars-Schneider models associated with $A_{n-1}$ root system with a discrete coupling constant are studied. The eigenvalues of the Hamiltonian are givein in terms of the Bethe ansatz formulas. Taking the "non-relativistic" limit, we obtain the spectrum of the corresponding Calogero-Moser systems in the third formulas of Felder et al [20].Comment: Latex file, 25 page

FHL2 regulates hematopoietic stem cell functions under stress conditions.

FHL2, a member of the four and one half LIM domain protein family, is a critical transcriptional modulator. Here, we identify FHL2 as a critical regulator of hematopoietic stem cells (HSCs) that is essential for maintaining HSC self-renewal under regenerative stress. We find that Fhl2 loss has limited effects on hematopoiesis under homeostatic conditions. In contrast, Fhl2-null chimeric mice reconstituted with Fhl2-null bone marrow cells developed abnormal hematopoiesis with significantly reduced numbers of HSCs, hematopoietic progenitor cells (HPCs), red blood cells and platelets as well as hemoglobin levels. In addition, HSCs displayed a significantly reduced self-renewal capacity and were skewed toward myeloid lineage differentiation. We find that Fhl2 loss reduces both HSC quiescence and survival in response to regenerative stress, probably as a consequence of Fhl2-loss-mediated downregulation of cyclin-dependent kinase-inhibitors, including p21(Cip) and p27(Kip1). Interestingly, FHL2 is regulated under the control of a tissue-specific promoter in hematopoietic cells and it is downregulated by DNA hypermethylation in the leukemia cell line and primary leukemia cells. Furthermore, we find that downregulation of FHL2 frequently occurs in myelodysplastic syndrome and acute myeloid leukemia patients, raising a possibility that FHL2 downregulation has a role in the pathogenesis of myeloid malignancies

Anyonic interferometry without anyons: How a flux qubit can read out a topological qubit

Proposals to measure non-Abelian anyons in a superconductor by quantum interference of vortices suffer from the predominantly classical dynamics of the normal core of an Abrikosov vortex. We show how to avoid this obstruction using coreless Josephson vortices, for which the quantum dynamics has been demonstrated experimentally. The interferometer is a flux qubit in a Josephson junction circuit, which can nondestructively read out a topological qubit stored in a pair of anyons --- even though the Josephson vortices themselves are not anyons. The flux qubit does not couple to intra-vortex excitations, thereby removing the dominant restriction on the operating temperature of anyonic interferometry in superconductors.Comment: 7 pages, 3 figures; Added an Appendix on parity-protected single-qubit rotations; problem with Figure 3 correcte