Upper Jurassic lituolids in the Sierra de Chiapas (Mexico) and their relation to the Tethys

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La Famille des Miscellaneidae, foraminifères du Paléocène et de l'Éocène inférieur : ni des nummulitidés, ni des rotaliidés

Les Miscellaneidae, formes lamellaires-perforées à coquille planispiralée involute, sont subdivisées en taxons à un seul foramen en position symétrique par rapport à l'équateur du test (Miscellanea s.str.) et taxons en ayant deux (Ornatononion) ou plus disposés en une rangée intériomarginale (Miscellanites). Dix espèces sont décrites, amplement illustrées et discutées en tenant compte du dimorphisme considérable des générations. La Famille des Miscella-neidae est attribuée comme groupement de grands foraminifères spécialisés à la Superfamille des Nonionacea, caractérisée entre autres par l'enroulement planispiralé-involute du test combiné avec une position intériomarginale des foramens. L'extension biostratigraphique de la famille couvre les biozones SBZ 2-5. La répartition paléogéographique correspond à toute la Néotéthys y compris le Golfe Pyré-néen. L'Atlantique n'est pas franchi ; les Caraïbes restent sans miscellanea. Deux structures extrêmes marquent la famille et sont d'un intérêt particulier pour l'anatomie comparée et fonctionnelle des grands foraminifères: Miscellanites meandrinus présente des extensions alaires méandriformes et Bolkarina aksarayi un test à loges d'expansion en forme de dôme en arrangement bisérié. On retrouve ces deux structures chez d'autres grands foraminifères sans aucune relation systématique ce qui permet d'interpréter ces structures extrêmes comme des analogies. Il doit exister des raisons fonction-nelles pour justifier qu'une telle structure soit répétée plusieurs fois dans des groupes systématiques sans relation mutuelle.The Miscellaneidae are divided into two groups of species: forms with a single intercameral foramen and forms with two or a row of multiple foramina. Ten taxa ascribed to this family are revised, amply illustrated and discussed considering both micro- and megalospheric generations. The Family Miscellaneidae is assigned to the Superfamily Nonionacea by reason of their planispiral-involute coiling combined with an interiomarginal position of the foramina. Their combined range covers SBZ zones 2-5 and an area comprising the Central and Western Neotethys including the Pyrenean Gulf. They do not reach the western shores of the Atlantic. Miscellanites meandrinus and Bolkarina aksarayi exhibit extreme morphological features, respectively meandrine alar extensions and expanse chambers. These features are of general interest for the comparative anatomy of the shells of the larger foraminifera in order to understand their biological significance

Glossaire illustré de termes utilisés dans la recherche sur les Foraminifères

Ce glossaire des termes utilisé dans l’analyse de l’architecture des tests récents et fossiles de Foraminifères, complété par une sélection rigoureuse de ces termes, facilite la compréhension de leur biologie et leur utilisation en écologie et en biostratigraphie. Il comporte près de 650 entrées accompagnées par 83 figures, souvent composites, dont de nombreuses images stéréographiques ou modélisations en 3D. Un index taxonomique répertorie les 140 taxons illustrés.An illustrated glossary of terms used in the analysis of the shells of recent and fossil foraminifera supplemented by a rigorous selection of terms that facilitate an understanding of their biology and their use in ecology and biostratigraphy. The glossary includes some 650 entries illustrated by 83 - often composite – figures many of which are stereographs or 3D models. A taxonomic index lists the 140 taxa illustrated

Cretaceous ammonites from Fuerteventura, Canary Islands

Mesozoic deep-water sediments occurring on the island of Fuerteventura were deposited near the continent-ocean boundary adjacent to the African margin. During Tertiary times, they were uplifted and intruded by ultramafic, mafic and alkaline plutons and dykes and are now exposed as part of the ‘Basal Complex' of the island. These sediments reflect more or less continuous hemipelagic and turbiditic deposition during most of Jurassic and Cretaceous times. Two ammonites, described in this paper, document a Valanginian to Hauterivian age for part of the Lower Cretaceous siliciclastic turbidites, and a latest Albian to early Cenomanian age for part of the Upper Cretaceous hemipelagic limestone

The foraminiferal genera Pararotalia, Neorotalia, and Calcarina: taxonomic revision

Scanning electron microscopy of the architecture of Rotalina inermis Terquem, 1882, the type-species of the genus Pararotalia Le Calvez, 1949, and of Rotalia mexicana Nuttall, 1928, the type-species of the genus Neorotalia Bermudez, 1952, reveals that both taxa have in common: 1) an umbilical bowl closed by either a single or a compound umbilical plug; 2) an interiomarginal extraumbilical aperture, restricted by a toothplate that protrudes with a free edge into the aperture and forms an umbilical spiral canal; and 3) a septal flap and intraseptal interlocular spaces. Rotalia mexicana, however, also possesses an enveloping canal-system, similar to that found in the Calcarinidae. For this reason Neorotalia must be regarded as a valid distinct genus, not synonymous with Pararotalia, as proposed by some authors. Calcarina calcar d'Orbigny, 1839, variously placed by authors in Rotalia Lamarck, 1804, in Pararotalia Le Calvez, 1949, and lately again in Calcarina d'Orbigny, 1826, is shown to possess the same basic architecture as Neorotalia and is placed, consequently, into this latter genus. Irregular supplementary apertures occurring in N. calcar are not considered of generic value and neither are they regarded as indicating a relationship with Nautilus spengleri Gmelin, 1788, the type-species of Calcarina. The latter, although characterized by a complex enveloping canal-system, possesses primary multiple interioareal main apertures, surrounded by thick rims, as well as a small umbilical plate, but lacks a toothplate with a free edge. For comparison, Pararotalia spinigera (Le Calvez, 1949) and Neorotalia viennoti (Greig, 1935) were also studied. The subfamily Pararotaliinae Reiss, 1963, is emended to include the canal-system as a characteristic feature. A glossary of selected terms is appende

Glossary and "eForams": free rapid access to the current basic knowledge on foraminifera

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Miocene shallow-water limestones from São Nicolau (Cabo Verde): Caribbean-type benthic fauna and time constraints for volcanism

Shallow-water limestones of presumed Late Cretaceous and Eocene age, interbedded with basaltic lavas, were described by earlier authors from São Nicolau in the northwestern part of the Cabo Verde archipelago. If confirmed, these ages would imply late Mesozoic shallow-marine and subaerial volcanic activity in the Cabo Verde archipelago, and document a geological history very different from that known so far from other Cabo Verde Islands, from which no subaerial volcanic activity before the mid-Cenozoic is known. Our re-investigation of the foraminiferal fauna indicates a Late Miocene age for the presumed Late Cretaceous and Eocene limestones. The hypothesis of a long-lived hot spot, active by the Early Cretaceous, and of a major island-building stage in the Cabo Verde Islands during this period, is therefore not supported by the present bio- or chronostratigraphic dat

A phase Ib/II randomized, open-label drug repurposing trial of glutamate signaling inhibitors in combination with chemoradiotherapy in patients with newly diagnosed glioblastoma: the GLUGLIO trial protocol

Background Glioblastoma is the most common and most aggressive malignant primary brain tumor in adults. Glioblastoma cells synthesize and secrete large quantities of the excitatory neurotransmitter glutamate, driving epilepsy, neuronal death, tumor growth and invasion. Moreover, neuronal networks interconnect with glioblastoma cell networks through glutamatergic neuroglial synapses, activation of which induces oncogenic calcium oscillations that are propagated via gap junctions between tumor cells. The primary objective of this study is to explore the efficacy of brain-penetrating anti-glutamatergic drugs to standard chemoradiotherapy in patients with glioblastoma. Methods/design GLUGLIO is a 1:1 randomized phase Ib/II, parallel-group, open-label, multicenter trial of gabapentin, sulfasalazine, memantine and chemoradiotherapy (Arm A) versus chemoradiotherapy alone (Arm B) in patients with newly diagnosed glioblastoma. Planned accrual is 120 patients. The primary endpoint is progression-free survival at 6 months. Secondary endpoints include overall and seizure-free survival, quality of life of patients and caregivers, symptom burden and cognitive functioning. Glutamate levels will be assessed longitudinally by magnetic resonance spectroscopy. Other outcomes of interest include imaging response rate, neuronal hyperexcitability determined by longitudinal electroencephalography, Karnofsky performance status as a global measure of overall performance, anticonvulsant drug use and steroid use. Tumor tissue and blood will be collected for translational research. Subgroup survival analyses by baseline parameters include segregation by age, extent of resection, Karnofsky performance status, O$^{6}$-methylguanine DNA methyltransferase (MGMT) promotor methylation status, steroid intake, presence or absence of seizures, tumor volume and glutamate levels determined by MR spectroscopy. The trial is currently recruiting in seven centers in Switzerland. Trial registration NCT05664464. Registered 23 December 2022