2,605 research outputs found
Playing with the “Playing God”
Some philosophers and theologians have argued against the idea of Human Enhancement,
saying that human beings should not play God. A closer look, however, might reveal that
the question of who is playing Whom is far from being so clear-cut. This chapter will address
the idea of human enhancement from the standpoint of theistic theology, arguing that human
enhancement and theistic theology may not be so very incompatible, after all
Symmetry in Critical Random Boolean Network Dynamics
Using Boolean networks as prototypical examples, the role of symmetry in the
dynamics of heterogeneous complex systems is explored. We show that symmetry of
the dynamics, especially in critical states, is a controlling feature that can
be used both to greatly simplify analysis and to characterize different types
of dynamics. Symmetry in Boolean networks is found by determining the frequency
at which the various Boolean output functions occur. There are classes of
functions that consist of Boolean functions that behave similarly. These
classes are orbits of the controlling symmetry group. We find that the symmetry
that controls the critical random Boolean networks is expressed through the
frequency by which output functions are utilized by nodes that remain active on
dynamical attractors. This symmetry preserves canalization, a form of network
robustness. We compare it to a different symmetry known to control the dynamics
of an evolutionary process that allows Boolean networks to organize into a
critical state. Our results demonstrate the usefulness and power of using the
symmetry of the behavior of the nodes to characterize complex network dynamics,
and introduce a novel approach to the analysis of heterogeneous complex
systems
Diffusive Logistic Equations with Harvesting and Heterogeneity Under Strong Growth Rate
We consider the equation −Δu=au−b(x)u2−ch(x) in Ω,u=0 on ∂Ω, where Ω is a smooth bounded domain in RN, b(x) and h(x) are nonnegative functions, and there exists Ω0⊂⊂Ω such that {x:b(x)=0}=Ω¯¯¯0. We investigate the existence of positive solutions of this equation for c large under the strong growth rate assumption a≥λ1(Ω0), where λ1(Ω0) is the first eigenvalue of the −Δ in Ω0 with Dirichlet boundary condition. We show that if h≡0 in Ω∖Ω¯¯¯0, then our equation has a unique positive solution for all c large, provided that a is in a right neighborhood of λ1(Ω0). For this purpose, we prove and utilize some new results on the positive solution set of this equation in the weak growth rate case
Three-Dimensional Bioprinting Materials with Potential Application in Preprosthetic Surgery
Current methods in handling maxillofacial defects are not robust and are highly dependent on the surgeon’s skills and the inherent potential in the patients’ bodies for regenerating lost tissues. Employing custom-designed 3D printed scaffolds that securely and effectively reconstruct the defects by using tissue engineering and regenerative medicine techniques can revolutionize preprosthetic surgeries. Various polymers, ceramics, natural and synthetic bioplastics, proteins, biomolecules, living cells, and growth factors as well as their hybrid structures can be used in 3D printing of scaffolds, which are still under development by scientists. These scaffolds not only are beneficial due to their patient-specific design, but also may be able to prevent micromobility, make tension free soft tissue closure, and improve vascularity. In this manuscript, a review of materials employed in 3D bioprinting including bioceramics, biopolymers, composites, and metals is conducted. A discussion of the relevance of 3D bioprinting using these materials for craniofacial interventions is included as well as their potential to create analogs to craniofacial tissues, their benefits, limitations, and their application
Metallic Coaxial Nanolasers
The last two decades have witnessed tremendous advancements in the area of
nanophotonics and plasmonics. Undoubtedly, the introduction of metallic
structures has opened a path towards light confinement and manipulation at the
subwavelength scale { a regime that was previously thought to be out of reach
in optics. Of central importance is to devise efficient light sources to power
up the future nanoscale optical circuits. Coaxial resonators can provide a
platform to implement such subwavelength sources. They support ultrasmall
cavity modes and offer large mode-emitter overlap as well as multifold
scalability. Given their large modulation bandwidth, they hold promise for high
speed optical interconnects { where they can be used for light generation and
modulation simultaneously. In addition, the possibility of thresholdless
operation in such devices may have implications in developing the next
generation of efficient lighting systems. In this review article, the physics
and applications of coaxial nanolasers will be discussed
The Efficacy of Commercial Tooth Storage Media for Maintaining the Viability of Human Periodontal Ligament Fibroblasts
Aim
To evaluate Save‐A‐Tooth (SAT), EMT Toothsaver (EMT) and Hank\u27s Balanced Salt Solution (HBSS) for their influence on the viability and proliferative capacity of human periodontal ligament fibroblasts (HPDLFs). Methodology
Primary HPDLFs were seeded into 96‐well cell culture plates and exposed to SAT, EMT, HBSS and water (negative control) for 0.5, 1, 3, 6, 12 and 24 h at room temperature (22 °C). After each exposure time, cell viability was measured through quantifying adenosine triphosphate (ATP) using a luminescent dye. The proliferative capacity was also quantified using the PrestoBlue assay after 12 or 24 h storage in each medium. The data were analysed statistically by two‐way anova and post hoc Least Significant Difference (LSD) test (P \u3c 0.05). The morphology of the cells after 12 h storage was also investigated through live/dead viability/cytotoxicity kit together with fluorescence microscopy. Results
There was no significant difference in cell viability amongst HBSS, SAT and EMT groups up to 6 h. SAT was effective in maintaining cell viability only up to 12 h and then became detrimental to HPDLF; after 24 h, the effectiveness of SAT in maintaining cell viability was similar to that of water (P \u3e 0.05). Amongst all the media, only EMT could maintain the proliferative capacity of HPDLFs significantly higher than the negative control, that is water (P \u3c 0.05) after 24 h storage. Conclusion
EMT maintained the proliferative capacity of HPDLFs after 24 h storage
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