Identifying Drug (Cocaine) Intake Events from Acute Physiological Response in the Presence of Free-living Physical Activity

A variety of health and behavioral states can potentially be inferred from physiological measurements that can now be collected in the free-living environment. The major challenge, however, is to develop computational models for automated detection of health events that can work reliably. In this work, we develop a physiologically-informed model to automatically detect drug (cocaine) use events in the free-living environment of participants from their electrocardiogram (ECG) measurements. The key to reliably detect these events is to incorporate the knowledge of autonomic nervous system (ANS) behavior in the model development so as to decompose the activation effect of cocaine from the natural recovery behavior of the parasympathetic nervous system (after an episode of physical activity). We collected 89 days of data from 9 active drug users in two residential lab environments and 922 days of data from 42 active drug users in the field environment, for a total of 11,283 hours. We developed a model that tracks the natural recovery by the parasympathetic nervous system and then estimates the dampening caused to the recovery by the activation of the sympathetic nervous system due to cocaine. We developed efficient methods to screen and clean the ECG time series data and extract candidate windows to assess for potential drug use. We then applied our model on the recovery segments from these windows. Our model achieves 100% true positive rate while keeping the false positive rate to 0.87/day over (9+ hours/day of) lab data and to 1.13/day over (11+ hours/day of) field data. In order to further improve the sensitivity and specificity of our model, we proposed several new data screening methods. Also we proposed a method to remove the effects of activities that acts as a confounder. We observed the false positive rates of 0.78 and 0.98 per day when we apply the enhanced model to the lab and field data respectively. Moreover, we observed that the proposed model has high specificity to cocaine. The method also estimates the dosage amount of drug for an event. However, the predicted dosage amount is not reliable for high dosage amounts in free living conditions

mCerebrum: A mobile sensing software platform for development and validation of digital biomarkers and interventions

The development and validation studies of new multisensory biomarkers and sensor-triggered interventions requires collecting raw sensor data with associated labels in the natural field environment. Unlike platforms for traditional mHealth apps, a software platform for such studies needs to not only support high-rate data ingestion, but also share raw high-rate sensor data with researchers, while supporting high-rate sense-analyze-act functionality in real-time. We present mCerebrum, a realization of such a platform, which supports high-rate data collections from multiple sensors with real-time assessment of data quality. A scalable storage architecture (with near optimal performance) ensures quick response despite rapidly growing data volume. Micro-batching and efficient sharing of data among multiple source and sink apps allows reuse of computations to enable real-time computation of multiple biomarkers without saturating the CPU or memory. Finally, it has a reconfigurable scheduler which manages all prompts to participants that is burden- and context-aware. With a modular design currently spanning 23+ apps, mCerebrum provides a comprehensive ecosystem of system services and utility apps. The design of mCerebrum has evolved during its concurrent use in scientific field studies at ten sites spanning 106,806 person days. Evaluations show that compared with other platforms, mCerebrum’s architecture and design choices support 1.5 times higher data rates and 4.3 times higher storage throughput, while causing 8.4 times lower CPU usage

puffMarker: A Multi-Sensor Approach for Pinpointing the Timing of First Lapse in Smoking Cessation

Recent researches have demonstrated the feasibility of detecting smoking from wearable sensors, but their performance on real-life smoking lapse detection is unknown. In this paper, we propose a new model and evaluate its performance on 61 newly abstinent smokers for detecting a first lapse. We use two wearable sensors - breathing pattern from respiration and arm movements from 6-axis inertial sensors worn on wrists. In 10-fold cross-validation on 40 hours of training data from 6 daily smokers, our model achieves a recall rate of 96.9%, for a false positive rate of 1.1%. When our model is applied to 3 days of post-quit data from 32 lapsers, it correctly pinpoints the timing of first lapse in 28 participants. Only 2 false episodes are detected on 20 abstinent days of these participants. When tested on 84 abstinent days from 28 abstainers, the false episode per day is limited to 1/6

mSieve

Differential privacy concepts have been successfully used to protect anonymity of individuals in population-scale analysis. Sharing of mobile sensor data, especially physiological data, raise different privacy challenges, that of protecting private behaviors that can be revealed from time series of sensor data. Existing privacy mechanisms rely on noise addition and data perturbation. But the accuracy requirement on inferences drawn from physiological data, together with well-established limits within which these data values occur, render traditional privacy mechanisms inapplicable. In this work, we define a new behavioral privacy metric based on differential privacy and propose a novel data substitution mechanism to protect behavioral privacy. We evaluate the efficacy of our scheme using 660 hours of ECG, respiration, and activity data collected from 43 participants and demonstrate that it is possible to retain meaningful utility, in terms of inference accuracy (90%), while simultaneously preserving the privacy of sensitive behaviors

Identifying drug (cocaine) intake events from acute physiological response in the presence of free-living physical activity

A variety of health and behavioral states can potentially be inferred from physiological measurements that can now be collected in the natural free-living environment. The major challenge, however, is to develop computational models for automated detection of health events that can work reliably in the natural field environment. In this paper, we develop a physiologically-informed model to automatically detect drug (cocaine) use events in the free-living environment of participants from their electrocardiogram (ECG) measurements. The key to reliably detecting drug use events in the field is to incorporate the knowledge of autonomic nervous system (ANS) behavior in the model development so as to decompose the activation effect of cocaine from the natural recovery behavior of the parasympathetic nervous system (after an episode of physical activity). We collect 89 days of data from 9 active drug users in two residential lab environments and 922 days of data from 42 active drug users in the field environment, for a total of 11,283 hours. We develop a model that tracks the natural recovery by the parasympathetic nervous system and then estimates the dampening caused to the recovery by the activation of the sympathetic nervous system due to cocaine. We develop efficient methods to screen and clean the ECG time series data and extract candidate windows to assess for potential drug use. We then apply our model on the recovery segments from these windows. Our model achieves 100% true positive rate while keeping the false positive rate to 0.87/day over (9+ hours/day of) lab data and to 1.13/day over (11+ hours/day of) field data

Dynamic models of stress-smoking responses based on high-frequency sensor data

Self-reports indicate that stress increases the risk for smoking; however, intensive data from sensors can provide a more nuanced understanding of stress in the moments leading up to and following smoking events. Identifying personalized dynamical models of stress-smoking responses can improve characterizations of smoking responses following stress, but techniques used to identify these models require intensive longitudinal data. This study leveraged advances in wearable sensing technology and digital markers of stress and smoking to identify person-specific models of stress and smoking system dynamics by considering stress immediately before, during, and after smoking events. Adult smokers (n = 45) wore the AutoSense chestband (respiration-inductive plethysmograph, electrocardiogram, accelerometer) with MotionSense (accelerometers, gyroscopes) on each wrist for three days prior to a quit attempt. The odds of minute-level smoking events were regressed on minute-level stress probabilities to identify person-specific dynamic models of smoking responses to stress. Simulated pulse responses to a continuous stress episode revealed a consistent pattern of increased odds of smoking either shortly after the beginning of the simulated stress episode or with a delay, for all participants. This pattern is followed by a dramatic reduction in the probability of smoking thereafter, for about half of the participants (49%). Sensor-detected stress probabilities indicate a vulnerability for smoking that may be used as a tailoring variable for just-in-time interventions to support quit attempts

Continuous in-the-field measurement of heart rate: Correlates of drug use, craving, stress, and mood in polydrug users

BACKGROUND: Ambulatory physiological monitoring could clarify antecedents and consequences of drug use and could contribute to a sensor-triggered mobile intervention that automatically detects behaviorally risky situations. Our goal was to show that such monitoring is feasible and can produce meaningful data. METHODS: We assessed heart rate (HR) with AutoSense, a suite of biosensors that wirelessly transmits data to a smartphone, for up to 4 weeks in 40 polydrug users in opioid-agonist maintenance as they went about their daily lives. Participants also self-reported drug use, mood, and activities on electronic diaries. We compared HR with self-report using multilevel modeling (SAS Proc Mixed). RESULTS: Compliance with AutoSense was good; the data yield from the wireless electrocardiographs was 85.7%. HR was higher when participants reported cocaine use than when they reported heroin use (F(2,9)=250.3, p\u3c.0001) and was also higher as a function of the dose of cocaine reported (F(1,8)=207.7, p\u3c.0001). HR was higher when participants reported craving heroin (F(1,16)=230.9, p\u3c.0001) or cocaine (F(1,14)=157.2, p\u3c.0001) than when they reported of not craving. HR was lower (p\u3c.05) in randomly prompted entries in which participants reported feeling relaxed, feeling happy, or watching TV, and was higher when they reported feeling stressed, being hassled, or walking. CONCLUSIONS: High-yield, high-quality heart-rate data can be obtained from drug users in their natural environment as they go about their daily lives, and the resultant data robustly reflect episodes of cocaine and heroin use and other mental and behavioral events of interest

Are we there yet? Feasibility of continuous stress assessment via wireless physiological sensors

Stress can lead to headaches and fatigue, precipitate addictive behaviors (e.g., smoking, alcohol and drug use), and lead to cardiovascular diseases and cancer. Continuous assessment of stress from sensors can be used for timely delivery of a variety of interventions to reduce or avoid stress. We investigate the feasibility of continuous stress measurement via two field studies using wireless physiological sensors - A four-week study with illicit drug users (n = 40), and a one-week study with daily smokers and social drinkers (n = 30). We find that 11+ hours/day of usable data can be obtained in a 4-week study. Significant learning effect is observed after the first week and data yield is seen to be increasing over time even in the fourth week. We propose a framework to analyze sensor data yield and find that losses in wireless channel is negligible; the main hurdle in further improving data yield is the attachment constraint. We show the feasibility of measuring stress minutes preceding events of interest and observe the sensor-derived stress to be rising prior to self-reported stress and smoking events