Antidiabetic Effects of Momordica charantia (Karela) in Male long Evans Rat

The hypoglycemic effect of Momordica charantia (Karela) has been reported from many laboratories. To our knowledge, the underlying biochemical mechanism of action of this important clinical effect has not been reported. During the course of investigation of this aspect of the herbal fruit, it was reported from our laboratory that ethanolic extract of Momordica charantia suppressed gluconeogenesis in normal and streptozotocin (STZ) induced diabetic rats by depressing the hepatic gluconeogenic enzymes fructose-1,6-bisphosphatase and glucose-6-phosphatase. The herbal extract had also enhanced the activity of glucose-6-phosphate dehydrogenase, the rate-limiting enzyme of hexose monophosphate shunt (a pathway for the oxidation of glucose)

An Efficient Solution to Travelling Salesman Problem using Genetic Algorithm with Modified Crossover Operator

The traveling salesman problem (TSP) is a famous NP-hard problem in the area of combinatorial optimization. It is utilized to locate the shortest possible route that visits every city precisely once and comes back to the beginning point from a given set of cities and distance. This paper proposes an efficient and effective solution for solving such a query. A modified crossover method using Minimal Weight Variable, Order Selection Crossover operator, a modified mutation using local optimization and a modified selection method using KMST is proposed. The crossover operator (MWVOSX) chooses a particular order from multiple orders which have the minimum cost and takes the remaining from the other parent in backward and forward order. Then it creates two new offspring. Further, it selects the least weight new offspring from those two offspring. The efficiency of the proposed algorithm is compared to the classical genetic algorithm. Comparisons show that our proposed algorithm provides much efficient results than the existing classical genetic algorithm

Integration of reproductive health services for men in health and family welfare centers in Bangladesh

Since the mid-1970s, the Bangladesh national family planning program primarily focused on motivating women to use modern contraceptive methods and encouraging them to seek services from clinics. In addition, female field workers were recruited to deliver contraceptive methods at homes. The program design facilitated women’s access to information and medical care through clinics and home visits. In the process, however, the medical needs of males were marginalized. Men generally seek services from pharmacies, private practitioners, and district hospitals, and often ignore preventive steps and postpone seeking medical care for chronic health conditions. In cases of acute illness, they often resort to self-medication. As noted in this report, the study’s aim was to integrate male reproductive health services within the existing government female-focused health-care delivery system. The study concluded that reproductive health services for men could easily be integrated into the health and family welfare centers without affecting the clinics’ focus on serving women and children

Integration of reproductive health service for men in health and family welfare centers in Bangladesh

Over the last 30 years, Bangladesh’s national family planning (FP) program has mainly concentrated its promotional efforts on women’s adoption of FP. While the government policy has been effective in influencing women to accept contraceptive methods, men’s role in FP has been completely neglected. Similarly, male RH services are hardly available at Health and Family Welfare Centres (HFWCs). This report describes a project aimed at integrating male RH services within the existing government female-focused health-care-delivery system. The study was implemented by NIPORT in collaboration with the Directorate of Family Planning and the Population Council. Interventions resulted in a substantial rise of male clients in the clinics, however nearly all came for the treatment of general health problems. Only a small number of male RTI/STI clients sought services from the clinics. Although unexpected, there was a substantial rise in the number of female clients. The study concluded that RH services for men could be easily integrated into HFWCs without affecting the female and child focus of the clinics and that augmentation of the total number of patients at HFWCs will lead to more effective use of resources and decreased cost of treatment

Reinventing Undergraduate Clinical Placements with a Switch to Delivery by Clinical Teaching Fellows

Purpose: Undergraduate clinical placements have the potential for significant improvement. Previous research has shown the growing value of clinical teaching fellows (CTFs) within medical education. Changing traditional placements to a model whereby CTFs have defined roles and lead the majority of teaching can positively reinvent undergraduate clinical teaching. We wanted to see how a structured teaching programme delivered by CTFs could affect student experience and personal development within a large associate teaching hospital. We consider how such a model could be implemented and explore the opportunities for CTFs to develop in personal and professional capacities. Methods: A mixed methods study was organised to assess student experience of a CTF-led placement. A novel structured teaching programme was delivered by 14 CTFs, who provided or were involved with the majority of teaching for all medical students. Thematic analysis was conducted on focus groups with 48 final year medical students from Queen Mary University of London following completion of their clinical placements. The same students were asked to complete an anonymous survey from which results were analysed using modified 5-point Likert scales. Results: Eight themes were identified from the focus groups. Students appreciated the increased individualisation, relevance and variety of teaching and the ability to record progress. Other perceived effects were higher teacher to student ratios, more learning opportunities and increased familiarity and reliability with CTFs. Of the students surveyed, 96% felt their overall placement experience was very good in comparison to previous placements elsewhere. Survey results supported focus group themes and demonstrated perceived growth in students’ personal development. Conclusion: Placement models where CTFs lead most teaching can improve medical undergraduate experience and training. A move towards CTF-delivered teaching can be of financial benefit to hospital trusts whilst allowing time for junior doctors to explore different clinical specialities and hone their teaching skills

Serological response and breakthrough infection after COVID-19 vaccination in patients with cirrhosis and post-liver transplant

BACKGROUND: Vaccine hesitancy and lack of access remain major issues in disseminating COVID-19 vaccination to liver patients globally. Factors predicting poor response to vaccination and risk of breakthrough infection are important data to target booster vaccine programs. The primary aim of the current study was to measure humoral responses to 2 doses of COVID-19 vaccine. Secondary aims included the determination of factors predicting breakthrough infection. METHODS: COVID-19 vaccination and Biomarkers in cirrhosis And post-Liver Transplantation is a prospective, multicenter, observational case-control study. Participants were recruited at 4-10 weeks following first and second vaccine doses in cirrhosis [n = 325; 94% messenger RNA (mRNA) and 6% viral vaccine], autoimmune liver disease (AILD) (n = 120; 77% mRNA and 23% viral vaccine), post-liver transplant (LT) (n = 146; 96% mRNA and 3% viral vaccine), and healthy controls (n = 51; 72% mRNA, 24% viral and 4% heterologous combination). Serological end points were measured, and data regarding breakthrough SARS-CoV-2 infection were collected. RESULTS: After adjusting by age, sex, and time of sample collection, anti-Spike IgG levels were the lowest in post-LT patients compared to cirrhosis (p < 0.0001), AILD (p < 0.0001), and control (p = 0.002). Factors predicting reduced responses included older age, Child-Turcotte-Pugh B/C, and elevated IL-6 in cirrhosis; non-mRNA vaccine in AILD; and coronary artery disease, use of mycophenolate and dysregulated B-call activating factor, and lymphotoxin-α levels in LT. Incident infection occurred in 6.6%, 10.6%, 7.4%, and 15.6% of cirrhosis, AILD, post-LT, and control, respectively. The only independent factor predicting infection in cirrhosis was low albumin level. CONCLUSIONS: LT patients present the lowest response to the SARS-CoV-2 vaccine. In cirrhosis, the reduced response is associated with older age, stage of liver disease and systemic inflammation, and breakthrough infection with low albumin level

Development of Nano-fibrous Polyelectrolyte Complex (PEC) powder for haemorrhage control

In this work, two different combinations of polyelectrolyte complex (PEC) based Nano-fibrous powder samples were prepared for haemorrhage control. One combination involves sodium alginate and chitosan, and the other involves casein and chitosan. After the fabrication process, to evaluate the physical properties, blood clotting ability and biological properties, several analysis and tests like FESEM, BET, Whole blood clotting assay, compressive strength measurement etc. were done. Study revealed that sodium alginate-chitosan (AL-CH) nano-powder had an average fibre diameter of 50-80 nm and surface area of about 250-400 m²/g. The nano-powder also had shown a blood clotting time of below 30 seconds. The other combination of Nano-powder composed of casein-chitosan(CA-CH) exhibited lower fibre diameter with an average fibre diameter of about 50 nm. CA-CH nano-powder also had shown better clotting efficiency with an average clotting time of 15 seconds

Efficient Stereo Depth Estimation for Pseudo-LiDAR: A Self-Supervised Approach Based on Multi-Input ResNet Encoder

Perception and localization are essential for autonomous delivery vehicles, mostly estimated from 3D LiDAR sensors due to their precise distance measurement capability. This paper presents a strategy to obtain a real-time pseudo point cloud from image sensors (cameras) instead of laser-based sensors (LiDARs). Previous studies (such as PSMNet-based point cloud generation) built the algorithm based on accuracy but failed to operate in real time as LiDAR. We propose an approach to use different depth estimators to obtain pseudo point clouds similar to LiDAR to achieve better performance. Moreover, the depth estimator has used stereo imagery data to achieve more accurate depth estimation as well as point cloud results. Our approach to generating depth maps outperforms other existing approaches on KITTI depth prediction while yielding point clouds significantly faster than other approaches as well. Additionally, the proposed approach is evaluated on the KITTI stereo benchmark, where it shows effectiveness in runtime

Efficient Stereo Depth Estimation for Pseudo-LiDAR: A Self-Supervised Approach Based on Multi-Input ResNet Encoder

Perception and localization are essential for autonomous delivery vehicles, mostly estimated from 3D LiDAR sensors due to their precise distance measurement capability. This paper presents a strategy to obtain a real-time pseudo point cloud from image sensors (cameras) instead of laser-based sensors (LiDARs). Previous studies (such as PSMNet-based point cloud generation) built the algorithm based on accuracy but failed to operate in real time as LiDAR. We propose an approach to use different depth estimators to obtain pseudo point clouds similar to LiDAR to achieve better performance. Moreover, the depth estimator has used stereo imagery data to achieve more accurate depth estimation as well as point cloud results. Our approach to generating depth maps outperforms other existing approaches on KITTI depth prediction while yielding point clouds significantly faster than other approaches as well. Additionally, the proposed approach is evaluated on the KITTI stereo benchmark, where it shows effectiveness in runtime