860 research outputs found
Reactivity of [Re\u3csub\u3e2\u3c/sub\u3e(CO)\u3csub\u3e8\u3c/sub\u3e(MeCN)\u3csub\u3e2\u3c/sub\u3e] with Thiazoles: Hydrido Bridged Dirhenium Compounds Bearing Thiazoles in Different Coordination Modes
Reactions of the labile compound [Re2(CO)8(MeCN)2] with thiazole and 4-methylthiazole in refluxing benzene afforded the new compounds [Re2(CO)7{μ-2,3-η2-C3H(R)NS}{η1-NC3H2(4-R)S}(μ-H)] (1, R = H; 2, R = CH3), [Re2(CO)6{μ-2,3-η2-C3H(R)NS}{η1-NC3H2(4-R)S}2(μ-H)] (3, R = H; 4, R = CH3) and fac-[Re(CO)3(Cl){η1-NC3H2(4-R)S}2] (5, R = H; 6, R = CH3). Compounds 1 and 2 contain two rhenium atoms, one bridging thiazolide ligand, coordinated through the C(2) and N atoms and a η1-thiazole ligand coordinated through the nitrogen atom to the same Re as the thiazolide nitrogen. Compounds 3 and 4 contain a Re2(CO)6 group with one bridging thiazolide ligand coordinated through the C(2) and N atoms and two N-coordinated η1-thiazole ligands, each coordinated to one Re atom. A hydride ligand, formed by oxidative-addition of C(2)–H bond of the ligand, bridges Re–Re bond opposite the thiazolide ligand in compounds 1–4. Compound 5 contains a single rhenium atom with three carbonyl ligands, two N-coordinated η1-thiazole ligands and a terminal Cl ligand. Treatment of both 1 and 2 with 5 equiv. of thiazole and 4-methylthiazole in the presence of Me3NO in refluxing benzene afforded 3 and 4, respectively. Further activation of the coordinated η1-thiazole ligands in 1–4 is, however, unsuccessful and results only nonspecific decomposition. The single-crystal XRD structures of 1–5 are reported
Joint degeneration in a mouse model of pseudoachondroplasia: ER stress, inflammation, and block of autophagy
Pseudoachondroplasia (PSACH), a short limb skeletal dysplasia associated with premature joint degeneration, is caused by misfolding mutations in cartilage oligomeric matrix protein (COMP). Here, we define mutant-COMP-induced stress mechanisms that occur in articular chondrocytes of MT-COMP mice, a murine model of PSACH. The accumulation of mutant-COMP in the ER occurred early in MT-COMP articular chondrocytes and stimulated inflammation (TNFα) at 4 weeks, and articular chondrocyte death increased at 8 weeks while ER stress through CHOP was elevated by 12 weeks. Importantly, blockage of autophagy (pS6), the major mechanism that clears the ER, sustained cellular stress in MT-COMP articular chondrocytes. Degeneration of MT-COMP articular cartilage was similar to that observed in PSACH and was associated with increased MMPs, a family of degradative enzymes. Moreover, chronic cellular stresses stimulated senescence. Senescence-associated secretory phenotype (SASP) may play a role in generating and propagating a pro-degradative environment in the MT-COMP murine joint. The loss of CHOP or resveratrol treatment from birth preserved joint health in MT-COMP mice. Taken together, these results indicate that ER stress/CHOP signaling and autophagy blockage are central to mutant-COMP joint degeneration, and MT-COMP mice joint health can be preserved by decreasing articular chondrocyte stress. Future joint sparing therapeutics for PSACH may include resveratrol
Attitude towards diabetes and social and family support among type 2 diabetes patients attending a tertiary-care hospital in Bangladesh: a cross-sectional study
Background: Bangladesh has been suffering from an epidemiological transition from infectious and maternal diseases to non-communicable lifestyle-related diseases like diabetes, cardiovascular diseases, cancers etc. The burden of diabetes has been increasing rapidly due to high incidence as well as poor glycemic control leading to various macro and micro-vascular complications. In this study, we aim to assess the attitude towards diabetes and social and family support among the Bangladeshi type 2 diabetic mellitus (T2DM) patients. Methods: This was a cross-sectional study among 144 patients with T2DM at the medicine outpatient department of Dhaka Medical College Hospital (DMCH) in Dhaka, Bangladesh between 1 July and 31 July 2014. Data collection was done by interviewing patients using structured questionnaire. Understanding diabetes, education/advice received, attitude towards diabetes, family and friend support were measured by validated scales adapted from diabetes care profile. Results: This study includes a total of 144 patients (101 males and 43 females) with type 2 diabetes aged between 20 and 84 years. 87 % of the patients had inadequate blood glucose control (fasting blood sugar >7.2 mmol/L or >130 mg/dl). Statistically significant differences were observed in the mean scores of various attitude scales (i.e. positive, negative, care ability and self-care adherence scale) among patients with adequate and inadequate blood glucose control (p < 0.05). Statistically significant positive correlations were found between these three categories of social and family support. Self-satisfaction with diabetic care was significantly associated with adequate blood glucose control (p = 0.05). Conclusions: Positive attitude towards diabetes management and support from friends and family were associated with adequate diabetes management. Appropriate public health interventions should be designed to educate and motivate the family members to offer greater support to the diabetes patients
Prevalence of Iron-deficiency Anaemia among University Students in Noakhali Region, Bangladesh
Iron-deficiency anaemia (IDA) is a common health problem in rural women
and young children of Bangladesh. The university students usually take
food from residential halls, and the food value of their diets is not
always balanced. This cross-sectional study was conducted to estimate
the prevalence of irondeficiency anaemia among the university students
of Noakhali region, Bangladesh. Haemoglobin level of 300
randomly-selected students was measured calorimetrically, using
Sahli\u2019s haemoglobinometer during October to December 2011.
Statistical analysis was done by using SPSS software for Windows
(version 16) (SPSS Inc., Chicago, IL, USA). In the study, 55.3%
students were found anaemic, of whom 36.7% were male, and 63.3% were
female. Students aged 20-22 years were more anaemic (43.4%) than other
age-groups. Majority (51.3%) of male students showed their haemoglobin
level in the range of 13-15 g/dL, followed by 26.0% and 21.3% with
10-12 g/dL and 16-18 g/dL respectively. Although 50.5% anaemic and
51.1% non-anaemic female students showed normal BMI\u2014lower
percentage than anaemic (60.7%) and nonanaemic (71.9%) male students,
the underweight students were found more anaemic than the overweight
and obese subjects. Regular breakfast-taking habit showed significant
(p=0.035, 95% CI 0.5-1.0) influence on IDA compared to non-regular
breakfast takers. Consumption of meat, fish, poultry, eggs, or peanut
butter regularly; junk food; multivitamins; and iron/iron-rich food
showed insignificant (p=0.097, 95% CI 0.5-1.1; p=0.053, 95% CI 1.1-2.3;
p=0.148, 95% CI 0.6-1.2; and p=0.487, 95% CI 0.7-1.4 respectively) role
in provoking IDA. In the case of non-anaemic subjects, all of the above
parameters were significant, except the junk food consumption (p=0.342,
95% CI 0.5-1.2). Our study revealed that majority of university
students, especially female, were anaemic that might be aggravated by
food habit and lack of awareness. The results suggest that anaemia can
be prevented by providing proper knowledge on the healthful diet,
improved lifestyle, and harmful effect of anaemia to the students
A systematic review of economic evaluations of health and health-related interventions in Bangladesh
<p>Abstract</p> <p>Background</p> <p>Economic evaluation is used for effective resource allocation in health sector. Accumulated knowledge about economic evaluation of health programs in Bangladesh is not currently available. While a number of economic evaluation studies have been performed in Bangladesh, no systematic investigation of the studies has been done to our knowledge. The aim of this current study is to systematically review the published articles in peer-reviewed journals on economic evaluation of health and health-related interventions in Bangladesh.</p> <p>Methods</p> <p>Literature searches was carried out during November-December 2008 with a combination of key words, MeSH terms and other free text terms as suitable for the purpose. A comprehensive search strategy was developed to search Medline by the PubMed interface. The first specific interest was mapping the articles considering the areas of exploration by economic evaluation and the second interest was to scrutiny the methodological quality of studies. The methodological quality of economic evaluation of all articles has been scrutinized against the checklist developed by Evers Silvia and associates.</p> <p>Result</p> <p>Of 1784 potential articles 12 were accepted for inclusion. Ten studies described the competing alternatives clearly and only two articles stated the perspective of their articles clearly. All studies included direct cost, incurred by the providers. Only one study included the cost of community donated resources and volunteer costs. Two studies calculated the incremental cost effectiveness ratio (ICER). Six of the studies applied some sort of sensitivity analysis. Two of the studies discussed financial affordability of expected implementers and four studies discussed the issue of generalizability for application in different context.</p> <p>Conclusion</p> <p>Very few economic evaluation studies in Bangladesh are found in different areas of health and health-related interventions, which does not provide a strong basis of knowledge in the area. The most frequently applied economic evaluation is cost-effectiveness analysis. The majority of the studies did not follow the scientific method of economic evaluation process, which consequently resulted into lack of robustness of the analyses. Capacity building on economic evaluation of health and health-related programs should be enhanced.</p
Severe facial dermatitis as a late complication of aesthetic rhinoplasty; a case report
BACKGROUND: Contact dermatitis, as a cutaneous complication after rhinoplasty, is of early onset, limited and transient. The cause of this dermatitis is irritant or allergic. Late onset skin complications are rare and non-inflammatory. CASE PRESENTATION: We are reporting an unexpected, severe allergic contact dermatitis of the face, in a young female, appearing one month following aesthetic rhinoplasty. She failed to respond to ordinary treatments for dermatitis. We did standard battery – including nitrofurazone, tincture of benzoin and hydrocortisone – patch test for the patient that showed sensitivity to benzoin and corticosteroid. CONCLUSIONS: In summary we report a case of a severe allergic contact dermatitis of the face, in a 21-year-old girl who underwent corrective aesthetic rhinoplasty, appearing one month following surgical operation. We were unable to find a similar report in the medical literature
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