Synthesis, Characterization and Application of Lithium intercalated boron nitride nanotubes

ABSTRACT: Synthesis of Lithium Intercalated Boron Nitride Nanotubes (Li-BNNT) was conducted in an attempt to gain access to their promising applications for electronics, lithium batteries, hydrogen storage, and supercapacitors. Through a series of reactions pure nanotubes intercalated with lithium are expected to show in the product. A variety of reactions are engineered to create optimal conditions for the product and the reaction is conducted at 700º or 800ºC with zinc acting as a catalyst. The products were then purified using hexane and characterized using Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), and Energy-dispersive X-ray Spectroscopy (EDX). Further purification, functionalization, and application will be performed to access the promising applications that Li-BNNT offers.B.A. (Bachelor of Arts

New Boron Analogues of Pyrophosphates and Deoxynucleoside Boranophosphates

Tetraethyldicyanoborane pyrophosphate (2) and 3'-(diethylphosphite-cyanoborano)-5'-dimethoxytrityl.N4-benzoyl-deoxycytidine (3) have been synthesized in 70% and 76% yields, respectively. The compatibility of the substituted boranophosphates with common protecting groups is hereby demonstrated

Carborane‐Containing Matrix Metalloprotease (MMP) Ligands as Candidates for Boron Neutron‐Capture Therapy (BNCT)

Based on the previously reported potent and selective sulfone hydroxamate inhibitors SC‐76276, SC‐78080 (SD‐2590), and SC‐77964, potent MMP inhibitors have been designed and synthesized to append a boron‐rich carborane cluster by employing click chemistry to target tumor cells that are known to upregulate gelatinases. Docking against MMP‐2 suggests binding involving the hydroxamate zinc‐binding group, key H‐bonds by the sulfone moiety with the peptide backbone residues Leu82 and Leu83, and a hydrophobic interaction with the deep P1’ pocket. The more potent of the two triazole regioisomers exhibits an IC50 of 3.7 nM versus MMP‐2 and IC50 of 46 nM versus MMP‐9

[η5-2,3-Bis(trimethylsilyl)-2,3-dicarba-nido-hexaborane(2−)]chlorido(N,N,N′,N′-tetramethylethylenediamine)dysprosium(III)

The structure of the title compound, [Dy(C8H22B4Si2)Cl(C6H16N2)], reveals that a center of symmetry exists within the dimeric half-sandwich units. Within each half-sandwich, the DyIII ion is coordinated by the five-membered ring of the carborane, tetramethylethyl­enediamine and the chloride ion

New Boron Delivery Agents

This proceeding article compiles current research on the development of boron delivery drugs for boron neutron capture therapy that was presented and discussed at the National Cancer Institute (NCI) Workshop on Neutron Capture Therapy that took place on April 20-22, 2022. The most used boron sources are icosahedral boron clusters attached to peptides, proteins (such as albumin), porphyrin derivatives, dendrimers, polymers, and nanoparticles, or encapsulated into liposomes. These boron clusters and/or carriers can be labeled with contrast agents allowing for the use of imaging techniques, such as PET, SPECT, and fluorescence, that enable quantification of tumor-localized boron and their use as theranostic agents.C.V. thanks the Spanish Ministerio de Economiay Competitividad (PID2019-106832RB-100) and the Generalitat de Catalunya (2017SGR1720). H.N. received a Grant-in-Aid for Scientific Research (B) (No. 21H02066) from MEXT, Japan. M.G.H.V. thanks the National Institutes of Health grant number T34 GM136452. R.P. thanks the National Institutes of Health, grant number R21 CA259911 and the Department of Neurosurgery, Cedars Sinai MedicalCenter, Los Angeles.With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000917-S).Peer reviewe

Knowledge or Money: Which One is More Important?

When I asked the students in my general Chemistry class whether grade is more important than knowledge, a majority of them opted for grades over knowledge and this answer did not surprise me a bit as the smart phones are available for them to think while their brains are corrupted or unused for most of the time. This brings one to the Einstein’s prediction that technology will develop to the point where there is no human interaction, which will be the day a new generation of idiots will emerge, and we are witnessing everywhere, including in the classrooms all over the world