2,233 research outputs found
Recommended from our members
Ruminating on the nature of intelligence: Personality predicts implicit theories and educational persistence
Proteomic Analysis of Ovarian Cancer Proximal Fluids: Validation of Elevated Peroxiredoxin 1 in Patient Peripheral Circulation
Background: Epithelial ovarian cancer (EOC) is the deadliest gynecologic malignancy in the United States. Unfortunately, a validated protein biomarker-screening test to detect early stage disease from peripheral blood has not yet been developed. The present investigation assesses the ability to identify tumor relevant proteins from ovarian cancer proximal fluids, including tissue interstitial fluid (TIF) and corresponding ascites, from patients with papillary serous EOC and translates these findings to targeted blood-based immunoassays. Methodology/Principal Findings: Paired TIF and ascites collected from four papillary serous EOC patients at the time of surgery underwent immunodepletion, resolution by 1D gel electrophoresis and in-gel digestion for analysis by liquid chromatography-tandem mass spectrometry, which resulted in an aggregate identification of 569 and 171 proteins from TIF and ascites, respectively. Of these, peroxiredoxin I (PRDX1) was selected for validation in serum by ELISA and demonstrated to be present and significantly elevated (p = 0.0188) in 20 EOC patients with a mean level of 26.0 ng/mL (±9.27 SEM) as compared to 4.19 ng/mL (±2.58 SEM) from 16 patients with normal/benign ovarian pathology. Conclusions/Significance: We have utilized a workflow for harvesting EOC-relevant proximal biofluids, including TIF and ascites, for proteomic analysis. Among the differentially abundant proteins identified from these proximal fluids, PRDX1 was demonstrated to be present in serum and shown by ELISA to be elevated by nearly 6-fold in papillary serous EOC patients relative to normal/benign patients. Our findings demonstrate the facile ability to discover potential EOC-relevant proteins in proximal fluids and confirm their presence in peripheral blood serum. In addition, our finding of elevated levels of PRDX1 in the serum of EOC patients versus normal/benign patients warrants further evaluation as a tumor specific biomarker for EOC. © 2011 Hoskins et al
On the nonlinearity interpretation of q- and f-deformation and some applications
q-oscillators are associated to the simplest non-commutative example of Hopf
algebra and may be considered to be the basic building blocks for the symmetry
algebras of completely integrable theories. They may also be interpreted as a
special type of spectral nonlinearity, which may be generalized to a wider
class of f-oscillator algebras. In the framework of this nonlinear
interpretation, we discuss the structure of the stochastic process associated
to q-deformation, the role of the q-oscillator as a spectrum-generating algebra
for fast growing point spectrum, the deformation of fermion operators in
solid-state models and the charge-dependent mass of excitations in f-deformed
relativistic quantum fields.Comment: 11 pages Late
A Search for Scalar Chameleons with ADMX
Scalar fields with a "chameleon" property, in which the effective particle
mass is a function of its local environment, are common to many theories beyond
the standard model and could be responsible for dark energy. If these fields
couple weakly to the photon, they could be detectable through the "afterglow"
effect of photon-chameleon-photon transitions. The ADMX experiment was used in
the first chameleon search with a microwave cavity to set a new limit on scalar
chameleon-photon coupling excluding values between 2*10^9 and 5*10^14 for
effective chameleon masses between 1.9510 and 1.9525 micro-eV.Comment: 4 pages, 3 figure
The effect of a sports chiropractic manual therapy intervention on the prevention of back pain, hamstring and lower limb injuries in semi-elite Australian Rules footballers: a randomized controlled trial
<p>Abstract</p> <p>Background</p> <p>Hamstring injuries are the most common injury in Australian Rules football. It was the aims to investigate whether a sports chiropractic manual therapy intervention protocol provided in addition to the current best practice management could prevent the occurrence of and weeks missed due to hamstring and other lower-limb injuries at the semi-elite level of Australian football.</p> <p>Methods</p> <p>Sixty male subjects were assessed for eligibility with 59 meeting entry requirements and randomly allocated to an intervention (n = 29) or control group (n = 30), being matched for age and hamstring injury history. Twenty-eight intervention and 29 control group participants completed the trial. Both groups received the current best practice medical and sports science management, which acted as the control. Additionally, the intervention group received a sports chiropractic intervention. Treatment for the intervention group was individually determined and could involve manipulation/mobilization and/or soft tissue therapies to the spine and extremity. Minimum scheduling was: 1 treatment per week for 6 weeks, 1 treatment per fortnight for 3 months, 1 treatment per month for the remainder of the season (3 months). The main outcome measure was an injury surveillance with a missed match injury definition.</p> <p>Results</p> <p>After 24 matches there was no statistical significant difference between the groups for the incidence of hamstring injury (OR:0.116, 95% CI:0.013-1.019, p = 0.051) and primary non-contact knee injury (OR:0.116, 95% CI:0.013-1.019, p = 0.051). The difference for primary lower-limb muscle strains was significant (OR:0.097, 95%CI:0.011-0.839, p = 0.025). There was no significant difference for weeks missed due to hamstring injury (4 v14, χ2:1.12, p = 0.29) and lower-limb muscle strains (4 v 21, χ2:2.66, p = 0.10). A significant difference in weeks missed due to non-contact knee injury was noted (1 v 24, χ2:6.70, p = 0.01).</p> <p>Conclusions</p> <p>This study demonstrated a trend towards lower limb injury prevention with a significant reduction in primary lower limb muscle strains and weeks missed due to non-contact knee injuries through the addition of a sports chiropractic intervention to the current best practice management.</p> <p>Trial registration</p> <p>The study was registered with the Australian and New Zealand Clinical Trials Registry (ACTRN12608000533392).</p
A descriptive study of a manual therapy intervention within a randomised controlled trial for hamstring and lower limb injury prevention
The journal has been informed by its publisher BioMed Central that contrary to the statement in this article [Wayne Hoskins, Henry Pollard, Chiropractic & Osteopathy 2010, 18:23], they have been advised by the authors' institution Macquarie University, that its Human Research Ethics Committee did not approve this study. Because the study was conducted without institutional ethics committee approval it has been retracted
A SQUID-based microwave cavity search for dark-matter axions
Axions in the micro eV mass range are a plausible cold dark matter candidate
and may be detected by their conversion into microwave photons in a resonant
cavity immersed in a static magnetic field. The first result from such an axion
search using a superconducting first-stage amplifier (SQUID) is reported. The
SQUID amplifier, replacing a conventional GaAs field-effect transistor
amplifier, successfully reached axion-photon coupling sensitivity in the band
set by present axion models and sets the stage for a definitive axion search
utilizing near quantum-limited SQUID amplifiers.Comment: 4 pages, 5 figures, submitted to PR
Acoustically driven storage of light in a quantum well
The strong piezoelectric fields accompanying a surface acoustic wave on a
semiconductor quantum well structure are employed to dissociate optically
generated excitons and efficiently trap the created electron hole pairs in the
moving lateral potential superlattice of the sound wave. The resulting spatial
separation of the photogenerated ambipolar charges leads to an increase of the
radiative lifetime by orders of magnitude as compared to the unperturbed
excitons. External and deliberate screening of the lateral piezoelectric fields
triggers radiative recombination after very long storage times at a remote
location on the sample.Comment: 4 PostScript figures included, Physical Review Letters, in pres
Direct measurement of stellar angular diameters by the VERITAS Cherenkov Telescopes
The angular size of a star is a critical factor in determining its basic
properties. Direct measurement of stellar angular diameters is difficult: at
interstellar distances stars are generally too small to resolve by any
individual imaging telescope. This fundamental limitation can be overcome by
studying the diffraction pattern in the shadow cast when an asteroid occults a
star, but only when the photometric uncertainty is smaller than the noise added
by atmospheric scintillation. Atmospheric Cherenkov telescopes used for
particle astrophysics observations have not generally been exploited for
optical astronomy due to the modest optical quality of the mirror surface.
However, their large mirror area makes them well suited for such
high-time-resolution precision photometry measurements. Here we report two
occultations of stars observed by the VERITAS Cherenkov telescopes with
millisecond sampling, from which we are able to provide a direct measurement of
the occulted stars' angular diameter at the milliarcsecond scale.
This is a resolution never achieved before with optical measurements and
represents an order of magnitude improvement over the equivalent lunar
occultation method. We compare the resulting stellar radius with empirically
derived estimates from temperature and brightness measurements, confirming the
latter can be biased for stars with ambiguous stellar classifications.Comment: Accepted for publication in Nature Astronom
- …