121 research outputs found
Phosphazene-Catalyzed Desymmetrization of Cyclohexadienone by Dithiane Addition
We report a desymmetrization of cyclohexadienones by intramolecular conjugate addition of a tethered dithiane nucleophile. Mild reaction conditions allow the formation of diversely functionalized fused bicyclic lactones. The products participate in facially selective additions from the convex surface, leading to allylic alcohol derivative
Boson-fermion unification, superstrings, and Bohmian mechanics
Bosonic and fermionic particle currents can be introduced in a more unified
way, with the cost of introducing a preferred spacetime foliation. Such a
unified treatment of bosons and fermions naturally emerges from an analogous
superstring current, showing that the preferred spacetime foliation appears
only at the level of effective field theory, not at the fundamental superstring
level. The existence of the preferred spacetime foliation allows an objective
definition of particles associated with quantum field theory in curved
spacetime. Such an objective definition of particles makes the Bohmian
interpretation of particle quantum mechanics more appealing. The superstring
current allows a consistent Bohmian interpretation of superstrings themselves,
including a Bohmian description of string creation and destruction in terms of
string splitting. The Bohmian equations of motion and the corresponding
probabilistic predictions are fully relativistic covariant and do not depend on
the preferred foliation.Comment: 30 pages, 1 figure, revised, to appear in Found. Phy
Academic freedom: in justification of a universal ideal
This paper examines the justification for, and benefits of, academic freedom to academics, students, universities and the world at large. The paper surveys the development of the concept of academic freedom within Europe, more especially the impact of the reforms at the University of Berlin instigated by Wilhelm von Humboldt. Following from this, the paper examines the reasons why the various facets of academic freedom are important and why the principle should continue to be supported
Production and Decay of D_1(2420)^0 and D_2^*(2460)^0
We have investigated and final states and
observed the two established charmed mesons, the with mass
MeV/c and width MeV/c and
the with mass MeV/c and width
MeV/c. Properties of these final states, including
their decay angular distributions and spin-parity assignments, have been
studied. We identify these two mesons as the doublet predicted
by HQET. We also obtain constraints on {\footnotesize } as a function of the cosine of the relative phase of the two
amplitudes in the decay.Comment: 15 pages in REVTEX format. hardcopies with figures can be obtained by
sending mail to: [email protected]
Measurement of the branching fraction for
We have studied the leptonic decay of the resonance into tau
pairs using the CLEO II detector. A clean sample of tau pair events is
identified via events containing two charged particles where exactly one of the
particles is an identified electron. We find . The result is consistent with
expectations from lepton universality.Comment: 9 pages, RevTeX, two Postscript figures available upon request, CLNS
94/1297, CLEO 94-20 (submitted to Physics Letters B
Measurement of the Decay Asymmetry Parameters in and
We have measured the weak decay asymmetry parameters (\aLC ) for two \LC\
decay modes. Our measurements are \aLC = -0.94^{+0.21+0.12}_{-0.06-0.06} for
the decay mode and \aLC = -0.45\pm 0.31 \pm
0.06 for the decay mode . By combining these
measurements with the previously measured decay rates, we have extracted the
parity-violating and parity-conserving amplitudes. These amplitudes are used to
test models of nonleptonic charmed baryon decay.Comment: 11 pages including the figures. Uses REVTEX and psfig macros. Figures
as uuencoded postscript. Also available as
http://w4.lns.cornell.edu/public/CLNS/1995/CLNS95-1319.p
Observation of the Charmed Baryon Decays to , , and
We have observed two new decay modes of the charmed baryon into
and using data collected with the
CLEO II detector. We also present the first measurement of the branching
fraction for the previously observed decay mode . The branching fractions for these three modes relative to
are measured to be , , and , respectively.Comment: 12 page uuencoded postscript file, postscript file also available
through http://w4.lns.cornell.edu/public/CLN
Multiple drivers of decline in the global status of freshwater crayfish (Decapoda: Astacidea)
International audienceRates of biodiversity loss are higher in freshwater ecosystems than in most terrestrial or marine ecosystems, making freshwater conservation a priority. However, prioritization methods are impeded by insufficient knowledge on the distribution and conservation status of freshwater taxa, particularly invertebrates. We evaluated the extinction risk of the world's 590 freshwater crayfish species using the IUCN Categories and Criteria and found 32% of all species are threatened with extinction. The level of extinction risk differed between families, with proportionally more threatened species in the Parastacidae and Astacidae than in the Cambaridae. Four described species were Extinct and 21% were assessed as Data Deficient. There was geographical variation in the dominant threats affecting the main centres of crayfish diversity. The majority of threatened US and Mexican species face threats associated with urban development, pollution, damming and water management. Conversely, the majority of Australian threatened species are affected by climate change, harvesting, agriculture and invasive species. Only a small proportion of crayfish are found within the boundaries of protected areas, suggesting that alternative means of long-term protection will be required. Our study highlights many of the significant challenges yet to come for freshwater biodiversity unless conservation planning shifts from a reactive to proactive approach
Isotopic Grand Unification with the Inclusion of Gravity (revised version)
We introduce a dual lifting of unified gauge theories, the first
characterized by the isotopies, which are axiom- preserving maps into broader
structures with positive-definite generalized units used for the representation
of matter under the isotopies of the Poincare' symmetry, and the second
characterized by the isodualities, which are anti-isomorphic maps with
negative-definite generalized units used for the representation of antimatter
under the isodualities of the Poincare' symmetry. We then submit, apparently
for the first time, a novel grand unification with the inclusion of gravity for
matter embedded in the generalized positive-definite units of unified gauge
theories while gravity for antimatter is embedded in the isodual isounit. We
then show that the proposed grand unification provides realistic possibilities
for a resolution of the axiomatic incompatibilities between gravitation and
electroweak interactions due to curvature, antimatter and the fundamental
space-time symmetries.Comment: 20 pages, Latex, revised in various details and with added reference
The Public Repository of Xenografts enables discovery and randomized phase II-like trials in mice
More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in mice could efficiently define therapeutic activity across heterogeneous tumors. To address this hypothesis, we established a large, publicly available repository of well-characterized leukemia and lymphoma PDXs that undergo orthotopic engraftment, called the Public Repository of Xenografts (PRoXe). PRoXe includes all de-identified information relevant to the primary specimens and the PDXs derived from them. Using this repository, we demonstrate that large studies of acute leukemia PDXs that mimic human randomized clinical trials can characterize drug efficacy and generate transcriptional, functional, and proteomic biomarkers in both treatment-naive and relapsed/refractory disease
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