Prevalence of high blood pressure in 122, 053 adolescents: A systematic review and meta-regression

Several studies have reported high prevalence of risk factors for cardiovascular disease in adolescents. To perform: i) systematically review the literature on the prevalence of high blood pressure (HBP) in adolescents; ii) analyze the possible methodological factors associated with HBP; and iii) compare the prevalence between developed and developing countries. We revised 10 electronic databases up to August 11, 2013. Only original articles using international diagnosis of HBP were considered. The pooled prevalence's of HBP were estimated by random effects. Meta-regression analysis was used to identify the sources of heterogeneity across studies. Fifty-five studies met the inclusion criteria and total of 122,053 adolescents included. The pooled-prevalence of HBP was 11.2%, 13% for boys, and 9.6% for girls (P < 0.01). Method of measurement of BP and year in which the survey was conducted were associated with heterogeneity in the estimates of HBP among boys. The data indicate that HBP is higher among boys than girls, and that the method of measurement plays an important role in the overall heterogeneity of HBP value distributions, particularly in boys

Efeito de novos inibidores de urease no desenvolvimento de Pennisetum glaucum L.

FertBio 2014

Osteoporosis and Falls: Problems Overlooked by the Portuguese Medical Community

Introdução: A prevalência da osteoporose continua a aumentar, aumentando a morbimortalidade associada às fraturas osteoporóticas, na maioria resultantes de queda, sendo a fratura do fémur proximal a de maior impacto socioeconómico. O nosso objetivo foi caracterizar uma amostra da população hospitalar com fratura do fémur proximal quanto a medidas preventivas e terapêuticas da osteoporose e quedas. Material e Métodos: Realizámos um estudo transversal retrospetivo em mulheres com idade mínima de 65 anos e fratura recente do fémur proximal internadas num serviço de Ortopedia, durante um ano, através de questionário desenvolvido para o efeito e consulta do processo clínico. Resultados: Avaliámos 100 doentes, a maioria com fratura decorrente de queda, no domicílio, durante o dia e em piso regular; 76% das doentes tinha antecedentes de queda e 42% história prévia de fratura osteoporótica. Considerando os critérios para instituição terapêutica apenas 5,3% da amostra se encontrava medicada. Verificou-se a existência de uma associação estatisticamente significativa entre a ocorrência de quedas e as fraturas osteoporóticas bem como com a implementação de medidas de prevenção do risco de queda. Conclusão: os resultados corroboram a importância das quedas e das fraturas osteoporóticas na saúde. Tendo por base a literatura, os custos diretos estimados com esta amostra serão de 1,34 M€ no primeiro ano pós-fratura. Considerando a taxa mínima de cobertura terapêutica e o potencial de redução de risco fraturário estabelecido, conclui-se que um tratamento adequado poderia reduzir estes valores em, no mínimo, 40%-45%.info:eu-repo/semantics/publishedVersio

Genome-wide burden and association analyses implicate copy number variations in asthma risk among children and young adults from Latin America.

The genetic architecture of asthma was relatively well explored. However, some work remains in the field to improve our understanding on asthma genetics, especially in non-Caucasian populations and with regards to commonly neglected genetic variants, such as Copy Number Variations (CNVs). In the present study, we investigated the contribution of CNVs on asthma risk among Latin Americans. CNVs were inferred from SNP genotyping data. Genome wide burden and association analyses were conducted to evaluate the impact of CNVs on asthma outcome. We found no significant difference in the numbers of CNVs between asthmatics and non-asthmatics. Nevertheless, we found that CNVs are larger in patients then in healthy controls and that CNVs from cases intersect significantly more genes and regulatory elements. We also found that a deletion at 6p22.1 is associated with asthma symptoms in children from Salvador (Brazil) and in young adults from Pelotas (Brazil). To support our results, we conducted an in silico functional analysis and found that this deletion spans several regulatory elements, including two promoter elements active in lung cells. In conclusion, we found robust evidence that CNVs could contribute for asthma susceptibility. These results uncover a new perspective on the influence of genetic factors modulating asthma risk

MAMMALS IN PORTUGAL : A data set of terrestrial, volant, and marine mammal occurrences in P ortugal

Mammals are threatened worldwide, with 26% of all species being includedin the IUCN threatened categories. This overall pattern is primarily associatedwith habitat loss or degradation, and human persecution for terrestrial mam-mals, and pollution, open net fishing, climate change, and prey depletion formarine mammals. Mammals play a key role in maintaining ecosystems func-tionality and resilience, and therefore information on their distribution is cru-cial to delineate and support conservation actions. MAMMALS INPORTUGAL is a publicly available data set compiling unpublishedgeoreferenced occurrence records of 92 terrestrial, volant, and marine mam-mals in mainland Portugal and archipelagos of the Azores and Madeira thatincludes 105,026 data entries between 1873 and 2021 (72% of the data occur-ring in 2000 and 2021). The methods used to collect the data were: live obser-vations/captures (43%), sign surveys (35%), camera trapping (16%),bioacoustics surveys (4%) and radiotracking, and inquiries that represent lessthan 1% of the records. The data set includes 13 types of records: (1) burrowsjsoil moundsjtunnel, (2) capture, (3) colony, (4) dead animaljhairjskullsjjaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8),observation in shelters, (9) photo trappingjvideo, (10) predators dietjpelletsjpine cones/nuts, (11) scatjtrackjditch, (12) telemetry and (13) vocalizationjecholocation. The spatial uncertainty of most records ranges between 0 and100 m (76%). Rodentia (n=31,573) has the highest number of records followedby Chiroptera (n=18,857), Carnivora (n=18,594), Lagomorpha (n=17,496),Cetartiodactyla (n=11,568) and Eulipotyphla (n=7008). The data setincludes records of species classified by the IUCN as threatened(e.g.,Oryctolagus cuniculus[n=12,159],Monachus monachus[n=1,512],andLynx pardinus[n=197]). We believe that this data set may stimulate thepublication of other European countries data sets that would certainly contrib-ute to ecology and conservation-related research, and therefore assisting onthe development of more accurate and tailored conservation managementstrategies for each species. There are no copyright restrictions; please cite thisdata paper when the data are used in publications.info:eu-repo/semantics/publishedVersio