Intersecting Shock-Wave/Turbulent Boundary-Layer Interactions at Mach 8.3

Experimental data for two three-dimensional intersecting shock-wave/turbulent boundary-layer interaction flows at Mach 8.3 are presented. The test bodies, composed of two sharp fins fastened to a flat-plate test bed, were designed to generate flows with varying degrees of pressure gradient, boundary-layer separation, and turning angle. The data include surface pressure and heat transfer distributions as well as mean flow-field surveys both in the undisturbed and interaction regimes. The data are presented in a convenient form to be used to validate existing or future computational models of these hypersonic flows. The data are also on a 3.5-inch diskette included and are available through E-mail

Experimental studies of hypersonic boundary-layer transition and effects of wind tunnel disturbances

Boundary layer transition data on cones and free stream disturbance levels were measured in a hypersonic wind tunnel and Mach 8 variable density hypersonic tunnel. Transition data were obtained by using different conical models and techniques for detecting the location of transition. The disturbance levels were measured by using hot wire anemometry and pressure transducers. The transition Reynolds numbers obtained from the tests correlated well when the fluctuating pressures measured at the surface of conical models were used as a correlating parameter

Fluctuations and massive separation in three-dimensional shock-wave/boundary-layer interactions

Shock-wave unsteadiness was observed in rapidly compressed supersonic turbulent boundary layer flows with significant separation. A Mach 2.85 shock-wave/turbulent boundary layer flow was set up over a series of cylinder-flare bodies in the High Reynolds Number Channel 1. The transition from fully attached to fully separated flow was studied using axisymmetric flares with increasing compression angles. In the second phase, the 30 deg flare was inclined relative to the cylinder axis, so that the effect on a separated flow of increasing 3 dimensionality could be observed. Two 3-D separated cases are examined. A simple conditional sampling technique is applied to the data to group them according to an associated shock position. Mean velocities and turbulent kinetic energies, computed from the conditionally samples data, are compared to those from the unsorted data and to computed values. Three basic questions were addressed: can conditional sampling be used to provide snapshots of the flow; are averaged turbulence quantities dominated by the bimodal nature of the interaction; and is the shock unsteadiness really important to computational accuracy

Src family kinases, HCK and FGR, associate with local inflammation and tumour progression in colorectal cancer

Background: In colorectal cancer (CRC), inflammatory responses have been reported to associate with patient survival. However, the specific signalling pathways responsible for regulating inflammatory responses are not clear. Src family kinases (SFKs) impact tumourigenic processes, including inflammation. Methods: The relationship between SFK expression, inflammatory responses and cancer specific survival (CSS) in stage I-III CRC patients was assessed using immunohistochemistry on a 272 patient discovery cohort and an extended 822 patient validation cohort. Results: In the discovery cohort, cytoplasmic FGR associated with improved CSS (P=0.019), with membrane HCK (p=0.093) trending towards poorer CSS. In the validation cohort membrane FGR (p=0.016), membrane HCK (p=0.019), and cytoplasmic HCK (p=0.030) all associated with poorer CSS. Both markers also associated with decreased proliferation and cytotoxic T-lymphocytes (all p<0.05). Furthermore, cytoplasmic HCK was an independent prognostic marker compared to common clinical factors. To assess synergy a combine FGR+HCK score was assessed. The membrane FGR+HCK score strengthened associations with poor prognosis (p=0.006), decreased proliferation (p<0.001) and cytotoxic T-lymphocytes (p<0.001) Conclusions: SFKs associate with prognosis and the local inflammatory response in patients with stage I-III CRC. Active membrane FGR and HCK work in parallel to promote tumour progression and down-regulation of the local inflammatory lymphocytic response

Features of the citrullinating peptidylarginine deiminase enzymes

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