1,272 research outputs found
Voltage-Mode Highpass, Bandpass, Lowpass and Notch Biquadratic Filters Using Single DDCC
A new voltage-mode multifunction biquadratic filter using one differential difference current conveyor (DDCC), two grounded capacitors and three resistors is presented. The proposed circuit offers the following attractive advantages: realizing highpass, bandpass, lowpass and notch filter functions, simultaneously, from the same circuit configuration; employing grounded capacitors, which is ideal for integration and simpler circuit configuration
High Input Impedance Voltage-Mode Universal Biquadratic Filters With Three Inputs Using Three CCs and Grounding Capacitors
Two current conveyors (CCs) based high input impedance voltage-mode universal biquadratic filters each with three input terminals and one output terminal are presented. The first circuit is composed of three differential voltage current conveyors (DVCCs), two grounded capacitors and four resistors. The second circuit is composed of two DVCCs, one differential difference current conveyor (DDCC), two grounded capacitors and four grounded resistors. The proposed circuits can realize all the standard filter functions, namely, lowpass, bandpass, highpass, notch and allpass filters by the selections of different input voltage terminals. The proposed circuits offer the features of high input impedance, using only grounded capacitors and low active and passive sensitivities. Moreover, the x ports of the DVCCs (or DDCC) in the proposed circuits are connected directly to resistors. This design offers the feature of a direct incorporation of the parasitic resistance at the x terminal of the DVCC (DDCC), Rx, as a part of the main resistance
Single ICCII Sinusoidal Oscillators Employing Grounded Capacitors
Two inverting second-generation current conveyors (ICCII) based sinusoidal oscillators are presented. The first sinusoidal oscillator is composed of one ICCII, two grounded capacitors and two resistors. The oscillation condition and oscillation frequency can be orthogonally controllable. The second sinusoidal oscillator is composed of one ICCII, two grounded capacitors and three resistors. The oscillation condition and oscillation frequency can be independently controllable through different resistors
Robustly Extracting Medical Knowledge from EHRs: A Case Study of Learning a Health Knowledge Graph
Increasingly large electronic health records (EHRs) provide an opportunity to
algorithmically learn medical knowledge. In one prominent example, a causal
health knowledge graph could learn relationships between diseases and symptoms
and then serve as a diagnostic tool to be refined with additional clinical
input. Prior research has demonstrated the ability to construct such a graph
from over 270,000 emergency department patient visits. In this work, we
describe methods to evaluate a health knowledge graph for robustness. Moving
beyond precision and recall, we analyze for which diseases and for which
patients the graph is most accurate. We identify sample size and unmeasured
confounders as major sources of error in the health knowledge graph. We
introduce a method to leverage non-linear functions in building the causal
graph to better understand existing model assumptions. Finally, to assess model
generalizability, we extend to a larger set of complete patient visits within a
hospital system. We conclude with a discussion on how to robustly extract
medical knowledge from EHRs.Comment: 12 pages, presented at PSB 202
Selective interlayer ferromagnetic coupling between the Cu spins in YBa Cu O grown on top of La Ca MnO
Studies to date on ferromagnet/d-wave superconductor heterostructures focus
mainly on the effects at or near the interfaces while the response of bulk
properties to heterostructuring is overlooked. Here we use resonant soft x-ray
scattering spectroscopy to reveal a novel c-axis ferromagnetic coupling between
the in-plane Cu spins in YBa Cu O (YBCO) superconductor when it
is grown on top of ferromagnetic La Ca MnO (LCMO) manganite
layer. This coupling, present in both normal and superconducting states of
YBCO, is sensitive to the interfacial termination such that it is only observed
in bilayers with MnO_2but not with La Ca interfacial
termination. Such contrasting behaviors, we propose, are due to distinct
energetic of CuO chain and CuO plane at the La Ca and
MnO terminated interfaces respectively, therefore influencing the transfer
of spin-polarized electrons from manganite to cuprate differently. Our findings
suggest that the superconducting/ferromagnetic bilayers with proper interfacial
engineering can be good candidates for searching the theorized
Fulde-Ferrel-Larkin-Ovchinnikov (FFLO) state in cuprates and studying the
competing quantum orders in highly correlated electron systems.Comment: Please note the change of the title. Text might be slightly different
from the published versio
Transcritical flow of a stratified fluid over topography: analysis of the forced Gardner equation
Transcritical flow of a stratified fluid past a broad localised topographic
obstacle is studied analytically in the framework of the forced extended
Korteweg--de Vries (eKdV), or Gardner, equation. We consider both possible
signs for the cubic nonlinear term in the Gardner equation corresponding to
different fluid density stratification profiles. We identify the range of the
input parameters: the oncoming flow speed (the Froude number) and the
topographic amplitude, for which the obstacle supports a stationary localised
hydraulic transition from the subcritical flow upstream to the supercritical
flow downstream. Such a localised transcritical flow is resolved back into the
equilibrium flow state away from the obstacle with the aid of unsteady coherent
nonlinear wave structures propagating upstream and downstream. Along with the
regular, cnoidal undular bores occurring in the analogous problem for the
single-layer flow modeled by the forced KdV equation, the transcritical
internal wave flows support a diverse family of upstream and downstream wave
structures, including solibores, rarefaction waves, reversed and trigonometric
undular bores, which we describe using the recent development of the nonlinear
modulation theory for the (unforced) Gardner equation. The predictions of the
developed analytic construction are confirmed by direct numerical simulations
of the forced Gardner equation for a broad range of input parameters.Comment: 34 pages, 24 figure
Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction
The use of a small molecule compound to reduce toxic repeat RNA transcripts or their translated aberrant proteins to target repeat-expanded RNA/DNA with a G4C2 motif is a promising strategy to treat C9orf72-linked disorders. In this study, the crystal structures of DNA and RNA-DNA hybrid duplexes with the -GGGCCG- region as a G4C2 repeat motif were solved. Unusual groove widening and sharper bending of the G4C2 DNA duplex A-DNA conformation with B-form characteristics inside was observed. The G4C2 RNA-DNA hybrid duplex adopts a more typical rigid A form structure. Detailed structural analysis revealed that the G4C2 repeat motif of the DNA duplex exhibits a hydration shell and greater flexibility and serves as a 'hot-spot' for binding of the anthracene-based nickel complex, NiII(Chro)2 (Chro = Chromomycin A3). In addition to the original GGCC recognition site, NiII(Chro)2 has extended specificity and binds the flanked G:C base pairs of the GGCC core, resulting in minor groove contraction and straightening of the DNA backbone. We have also shown that Chro-metal complexes inhibit neuronal toxicity and suppresses locomotor deficits in a Drosophila model of C9orf72-associated ALS. The approach represents a new direction for drug discovery against ALS and FTD diseases by targeting G4C2 repeat motif DNA
Wearable, Multimodal, Biosignal Acquisition System for Potential Critical and Emergency Applications
For emergency or intensive-care units (ICUs), patients with unclear consciousness or unstable hemodynamics often require aggressive monitoring by multiple monitors. Complicated pipelines or lines increase the burden on patients and inconvenience for medical personnel. Currently, many commercial devices provide related functionalities. However, most devices measure only one biological signal, which can increase the budget for users and cause difficulty in remote integration. In this study, we develop a wearable device that integrates electrocardiography (ECG), electroencephalography (EEG), and blood oxygen machines for medical applications with the hope that it can be applied in the future. We develop an integrated multiple-biosignal recording system based on a modular design. The developed system monitors and records EEG, ECG, and peripheral oxygen saturation (SpO2) signals for health purposes simultaneously in a single setting. We use a logic level converter to connect the developed EEG module (BR8), ECG module, and SpO2 module to a microcontroller (Arduino). The modular data are then smoothly encoded and decoded through consistent overhead byte stuffing (COBS). This developed system has passed simulation tests and exhibited proper functioning of all modules and subsystems. In the future, the functionalities of the proposed system can be expanded with additional modules to support various emergency or ICU applications
Spontaneous Crystallization of Skyrmions and Fractional Vortices in the Fast-rotating and Rapidly-quenched Spin-1 Bose-Einstein Condensates
We investigate the spontaneous generation of crystallized topological defects
via the combining effects of fast rotation and rapid thermal quench on the
spin-1 Bose-Einstein condensates. By solving the stochastic projected
Gross-Pitaevskii equation, we show that, when the system reaches equilibrium, a
hexagonal lattice of skyrmions, and a square lattice of half-quantized vortices
can be formed in a ferromagnetic and antiferromagnetic spinor BEC, respetively,
which can be imaged by using the polarization-dependent phase-contrast method
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