Advancements in the Epsilon Launch Vehicle\u27s Rideshare Capability and Future Missions

Fifth Epsilon launch vehicle (Epsilon-5) with Innovative Satellite Technology Demonstration-2 was successfully launched from JAXA Uchinoura Space Center in Kagoshima, Japan on November 9, 2021. Successful injection of nine satellites with high accuracy demonstrated the capability of Epsilon launch vehicle for rideshare missions of various satellite sizes. The new Epsilon Satellite Mount Structure-II (ESMS-II) and an adapter was developed to launch more satellites. In the paper, we first introduce Epsilon launch vehicle and its multi-launch capability. Then, we describe the mission design of Epsilon-5 and rideshare specific configuration. Finally, we mention the rideshare opportunity provided by Epsilon launch vehicle in the future

Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervated Mice

Flavonoids have attracted considerable attention in relation to their effects upon health. 8-Prenylnaringenin (8-PN) is found in the common hop (Humulus lupulus) and assumed to be responsible for the health impact of beer consumption. We wanted to clarify the effects of prenylation on the physiological functions of dietary flavonoids by comparing the effects of 8-PN with that of intact naringenin in the prevention of disuse muscle atrophy using a model of denervation in mice. Consumption of 8-PN (but not naringenin) prevented loss of weight in the gastrocnemius muscle further supported by the lack of induction of the protein content of a key ubiquitin ligase involved in muscle atrophy, atrogin-1, and by the activation of Akt phosphorylation. 8-PN content in the gastrocnemius muscle was tenfold higher than that of naringenin. These results suggested that, compared with naringenin, 8-PN was effectively concentrated into skeletal muscle to exert its preventive effects upon disuse muscle atrophy. It is likely that prenylation generates novel functions for 8-PN by enhancing its accumulation into muscle tissue through dietary intake

8-PN promotes recovery from muscle atrophy via Akt pathway

8-Prenylnaringenin (8-PN) is a prenylflavonoid that originates from hop extracts and is thought to help prevent disuse muscle atrophy. We hypothesized that 8-PN affects muscle plasticity by promoting muscle recovery under disuse muscle atrophy. To test the promoting effect of 8-PN on muscle recovery, we administered an 8-PN mixed diet to mice that had been immobilized with a cast to one leg for 14 days. Intake of the 8-PN mixed diet accelerated recovery from muscle atrophy, and prevented reductions in Akt phosphorylation. Studies on cell cultures of mouse myotubes in vitro demonstrated that 8-PN activated the PI3K/Akt/P70S6K1 pathway at physiologic concentrations. A cell-culture study using an inhibitor of estrogen receptors and an in vivo experiment with ovariectomized mice suggested that the estrogenic activity of 8-PN contributed to recovery from disuse muscle atrophy through activation of an Akt phosphorylation pathway. These data strongly suggest that 8-PN is a naturally occurring compound that could be used as a nutritional supplement to aid recovery from disuse muscle atrophy

The Successful Launch of the Fourth Epsilon Launch Vehicle and its Future Rideshare Plans

The fourth Epsilon launch vehicle conducted its first rideshare mission on January 18, 2019. It successfully delivered seven satellites to the Sun Synchronous Orbit (SSO). In order to accommodate the demands in carrying satellites with various sizes, the Epsilon Satellite Mount Structure (ESMS) and the Epsilon Small Satellite Orbital Deployer (E-SSOD) was developed. The paper first introduces features of the rideshare configuration of the Epsilon. Then, the mission design and the injection accuracy of the fourth Epsilon launch are described. Further, plans for the future rideshare opportunities are presented

Prevention of disuse muscle atrophy by dietary ingestion of 8-prenylnaringenin in denervated mice.

Flavonoids have attracted considerable attention in relation to their effects upon health. 8-Prenylnaringenin (8-PN) is found in the common hop (Humulus lupulus) and assumed to be responsible for the health impact of beer consumption. We wanted to clarify the effects of prenylation on the physiological functions of dietary flavonoids by comparing the effects of 8-PN with that of intact naringenin in the prevention of disuse muscle atrophy using a model of denervation in mice. Consumption of 8-PN (but not naringenin) prevented loss of weight in the gastrocnemius muscle further supported by the lack of induction of the protein content of a key ubiquitin ligase involved in muscle atrophy, atrogin-1, and by the activation of Akt phosphorylation. 8-PN content in the gastrocnemius muscle was tenfold higher than that of naringenin. These results suggested that, compared with naringenin, 8-PN was effectively concentrated into skeletal muscle to exert its preventive effects upon disuse muscle atrophy. It is likely that prenylation generates novel functions for 8-PN by enhancing its accumulation into muscle tissue through dietary intake

Malignant Lymphoma of the Ileum Treated by Laparoscopically Assisted Bowel Resection : A Case Report

Primary malignant lymphoma of the small intestine is uncommon. We herein present a case of malignant lymphoma of the ileum, which was treated by laparoscopically assisted surgery. A 60-yearold male with lower abdominal pain and vomiting was admitted to our hospital. A standing abdominal X-ray showed niveau formation. Computed tomography demonstrated circumferential wall thickening in the terminal ileum. Laparoscopically assisted surgery was performed under a diagnosis of tumor of the ileum. Under laparoscopic exploration, tumor of the ileum was detected. Partial resection of the ileum and dissection of lymph nodes were performed extracorporeally. Histological findings demonstrated diffuse large atypical lymphocytes with vesicle-like chromatin and clear nucleolus. Immunologically, CD20 and CD79a were positive. These findings were compatible with those of diffuse large B-cell lymphoma. Paraintestinal lymph nodes were also involved. The postoperative course was uneventful. Neither gallium scintigraphy nor FDG-PET showed any scintillation. The patient was given R-CHOP therapy and is currently doing well with no sign of recurrence. In conclusion, we propose that laparoscopic surgery for malignant lymphoma of the small intestine is a feasible and promising therapeutic option, especially in a case demonstrating bowel obstruction, because this procedure is thought to be minimally invasive,allows quick postoperative recovery and shortened hospital stay could be expected

Biostratigraphy (calcareous nannofossils, planktic foraminifera, and radiolaria) and chemostratigraphy (strontium isotope ratios, and stable oxygen and carbon isotope ratios) at DSDP Site 296

We revisited the stratigraphy at Deep Sea Drilling Project (DSDP) Site 296, which has promise as a reference sequence for the mid-latitude western North Pacific. We constructed the biostratigraphy (calcareous nannofossils, planktic foraminifera, and radiolaria) and chemostratigraphy (strontium isotope ratios, and stable oxygen and carbon isotope ratios) to reveal continuous sedimentation at Site 296 through the past 20 million years (Myr). The biostratigraphy of calcareous nannofossils comprised 27 biohorizons from biozones NN2 to NN21 (early Miocene to Pleistocene), which are consistent with the biohorizons of planktic foraminifera and radiolaria. The uninterrupted sedimentation throughout the past 20 Myr was further supported by strontium isotope stratigraphy aligned to nannofossil datums and by correlation of stable isotope data from benthic foraminifera with an isotopic compilation from the Pacific Ocean. The refined age–depth model showed low sedimentation rates (<2 cm/kyr) through most of the Miocene and higher sedimentation rates (2–4 cm/kyr) during the Plio–Pleistocene, and potentially identified the “biogenic bloom” event from the late Miocene to early Pliocene. The continuity of sedimentation through the middle Miocene contrasts with the shipboard biostratigraphy, which inferred a hiatus (erosion or non-deposition) during the middle Miocene. Thus, the revised stratigraphy at Site 296 provides a key to correlation with other deep-sea sites in the North Pacific. Our revised age–depth model provides a framework for future studies of important climatic events during the Miocene, including the Miocene Climatic Optimum, the middle Miocene Climatic Transition, and the late Miocene global cooling under the influence of the past Kuroshio Current