Investigation of evolution strategy and optimization of induction heating model

An optimal design method using the finite element method and the evolution strategy (ES) is investigated. The evolution strategy is applied to the optimization of induction heating model. The position of auxiliary coil, frequency and ampere-turns are optimized so that the distribution of eddy current density on the surface of steel becomes uniform. It is shown that the selection of the appropriate parameter is important in the practical application of ES</p

3-D optimization of design variables in x-, y- and z-directions of transformer tank shield model

By using the automatic 3-D mesh generation technique using hexahedral elements, which is applicable when design variables are changed in x-, y- and z-directions, a transformer tank shield model is optimized. The volume of tank shield can be considerably reduced by using the Rosenbrock's method (RBM) compared with the previous result having design variables in one direction. It is shown that the determination of initial values for RBM using the experimental design method (EDM) is indispensable for the practical application of the optimization method to obtain a desired result within an acceptable CPU time </p

Optimal design of tank shield model of transformer

A tank shield model of a transformer which is proposed by the Investigation Committee of IEE of Japan is analyzed. This is a model having the constraint that the maximum eddy current density should be less than a specified value. The automatic 3D mesh generation technique for hexahedral element is investigated for the optimal design of such a model. It is shown that reasonable results that satisfy the specified constraints can be obtained using Rosenbrock's method within the acceptable CPU time. The experimental verification is also carried out</p

A Human Head and Neck Squamous Cell Carcinoma Cell Line with Acquired cis-Diamminedichloroplatinum-Resistance Shows Remarkable Upregulation of BRCA1 and Hypersensitivity to Taxane

Recently, an inverse relationship between resistance to platinum-based chemotherapeutic agents and taxanes has been implicated in breast and ovarian cancers, and a possible pivotal role for BRCA1 has also been suggested. Because cis-diamminedichloroplatinum (CDDP) and taxanes are the most active antitumor agents against head and neck squamous cell carcinoma (HNSCC), we analyzed the sensitivity of nine HNSCC cell lines and their previously established derived CDDP-resistant cell lines to two representative taxanes: docetaxel and paclitaxel. None of the nine original cell lines showed any cross resistance between CDDP and taxanes, but one of the CDDP-resistant cell lines, RPMI2650CR, demonstrated hypersensitivity to both taxanes when compared to the parental cell line, RPMI2650. Furthermore, RPMI2650CR exhibited increased expression of BRCA1. These data suggest that (i) taxanes are a good candidate for a second-line therapeutic drug for HNSCC patients with acquired CDDP resistance and (ii) BRCA1 can be a candidate marker for predicting an inverse CDDP/taxane sensitivity phenotype in HNSCC

Magnetization and transport properties in the superconducting Pr2_{2}Ba4_{4}Cu7_{7}O15−δ_{15-\delta} with metallic double-chain

We have reported the effect of pressure on the magnetization, and transport properties in the nominal composition Pr$_{2}$Ba$_{4}$Cu$_{7}$O$_{15-\delta}$ synthesized by a sol-gel technique. A reduction treatment of the as-sintered sample in vacuum causes higher superconductivity achieving $T_{c,on}=\sim 30$ K for $\delta =0.94$. Application of hydrostatic pressure on the oxygen depleted sample enhances its onset temperature up to 36 K at 1.2 GPa, indicating the nearly optimum doping level of the charge carrier in comparison to the pressure dependence of lower $T_{c}$ samples with $\delta =0.45$. Seebeck coefficient of the superconducting sample shows a metallic conduction, followed by a clear drop below $T_{c,on}$ and is in its temperature dependence below 100 K quite different from that of the non-superconducting one. This finding strongly suggests a dramatic change of the electronic state along the CuO double chain due to the reduction treatment for the appearance of superconductivity .Comment: 5 pages,4 figure

Eosinophil Hyporesponse of Jirds Induced by Microfilariae of Brugia Pahangi

Male jirds (Meriones unguiculatus) were inoculated sc with 100 infective larvae of Brugia pahangi. After 16 weeks, the animals were reinoculated with a comparable number of organisms. Blood eosinophil responses during the 5 weeks subsequent to this attempt to reinfect were much lower than those of comparable naive animals, while the response to a heterologous infection (Toxocara canis) was comparable to that of controls. Mebendazole was given to infected animals for 2 weeks beginning 5 weeks (prepatent) or 16 weeks (patent) after infection. At comparable intervals after drug administration, the animals were reinoculated with infective larvae and the blood eosinophil response was measured over a 5 week period. The response in the animals treated during the prepatent period was higher than the untreated infected controls. Treatment during the patent period had no demonstrable effect. Jirds made artificially microfilaremic by intravenous inoculation of viable filaria before and after the standard infecting dose had a low eosinophil response to infective larvae

高齢の非代償性心不全患者において、非心血管疾患、特に感染症は重要な死因である

BACKGROUND:Despite marked improvements in treatment strategies for heart failure (HF), the mortality rate of elderly patients with HF is still high. Detailed causes of death have not been fully understood.METHODS AND RESULTS:We studied 459 consecutive patients with acute decompensated HF (ADHF) emergently admitted to our hospital from 2007 to 2011. Patients were divided into 2 groups: <75 years old (younger group; n = 225) and ≥75 years old (elderly group; n = 234). All-cause death, cardiovascular death, and noncardiovascular death were assessed as adverse outcomes. Compared with the younger group, the elderly group was characterized by a higher proportion of women and hypertensive patients and higher left ventricular ejection fraction. During a mean follow-up of 20.7 months, a total of 174 patients (37.9%) died. All-cause death was significantly higher in the elderly group than in the younger group (46.6% vs 28.9%; P < .0001), and this difference was caused by an increase in noncardiovascular deaths (20.9% vs 9.3%; P < .001), especially deaths due to infection (10.7% vs 4.0%; P < .01). Cardiovascular deaths did not differ between the 2 groups.CONCLUSIONS:Noncardiovascular deaths, most of which were caused by infection, were frequent among elderly patients with ADHF.博士（医学）・甲第629号・平成27年3月16日Copyright © 2014 Elsevier Inc. All rights reserved

Clues to Evolution of the SERA Multigene Family in 18 Plasmodium Species

SERA gene sequences were newly determined from 11 primate Plasmodium species including two human parasites, P. ovale and P. malariae, and the evolutionary history of SERA genes was analyzed together with 7 known species. All have one each of Group I to III cysteine-type SERA genes and varying number of Group IV serine-type SERA genes in tandem cluster. Notably, Group IV SERA genes were ascertained in all mammalian parasite lineages; and in two primate parasite lineages gene events such as duplication, truncation, fragmentation and gene loss occurred at high frequency in a manner that mimics the birth-and-death evolution model. Transcription profile of individual SERA genes varied greatly among rodent and monkey parasites. Results support the lineage-specific evolution of the Plasmodium SERA gene family. These findings provide further impetus for studies that could clarify/provide proof-of-concept that duplications of SERA genes were associated with the parasites' expansion of host range and the evolutionary conundrums of multigene families in Plasmodium