The great ideas of biology: Exploration through experimentation in an undergraduate lab course

We developed an introductory laboratory course to provide a visceral experience that aims at getting students truly excited about scientific study of the living world. Our vehicle to do that was to focus on what Paul Nurse dubbed “the great ideas of biology” rather than an approach to biology that celebrates specific factual knowledge. To that end, we developed eight diverse experimental modules, each of which highlights a key biological concept and gives an opportunity to use theory to generate testable hypotheses, to perform high quality measurements to test those hypotheses (some of which are clearly wrong), and to perform sophisticated computational data analysis. Some modules incorporate modern microscopy and computational techniques in classic experiments, such as bacterial growth and the Luria‐Delbrück experiment, while others address current research questions using methods like optogenetics and single molecule measurements. We have offered the course eight times, and in the most recent edition of the course, we conducted pre/post‐course interviews and attitude surveys. The students, both bio and non‐bio majors alike, reported being captivated by seeing life occur across the broad range of experiments and model organisms. We observed demonstrable development of their curiosity and enthusiasm for biology. Additionally, we found that prior to the course, students had only vague notions about what it means to make quantitative biological measurements and interpret them. They completed the course with a clearer understanding of scientific inquiry in biology and the skills and confidence to actually perform and interpret measurements in living systems

Possible co-existence of local itinerancy and global localization in a quasi-one-dimensional conductor

In the chain compound PrBa$_2$Cu$_4$O$_8$ localization appears simultaneously with a dimensional crossover in the electronic ground state when the scattering rate in the chains exceeds the hopping rate between the chains. Here we report the discovery of a large, transverse magnetoresistance in PrBa$_2$Cu$_4$O$_8$ in the localized regime. This result suggests a novel form of localization whereby electrons retain their metallic (quasi-one-dimensional) character over a microscopic length scale despite the fact that macroscopically, they exhibit localized (one-dimensional) behavior.Comment: 4 pages, 4 Figure

Angle-resolved photoemission study of insulating and metallic Cu-O chains in PrBa2_2Cu3_3O7_7 and PrBa2_2Cu4_4O8_8

We compare the angle-resolved photoemission spectra of the hole-doped Cu-O chains in PrBa$_2$Cu$_3$O$_7$ (Pr123) and in PrBa$_2$Cu$_4$O$_8$ (Pr124). While, in Pr123, a dispersive feature from the chain takes a band maximum at $k_b$ (momentum along the chain) $\sim$ $\pi/4$ and loses its spectral weight around the Fermi level, it reaches the Fermi level at $k_b$ $\sim$ $\pi/4$ in Pr124. Although the chains in Pr123 and Pr124 are approximately 1/4-filled, they show contrasting behaviors: While the chains in Pr123 have an instability to charge ordering, those in Pr124 avoid it and show an interesting spectral feature of a metallic coupled-chain system.Comment: 4 pages, 5 figures, to be published in PR

Evidence for B- -> Ds+ K- l- nubar and search for B- -> Ds*+ K- l- nubar

We report measurements of the decays B- -> Ds(*)+ K- l- nubar in a data sample containing 657x10^6 BBbar pairs collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. We observe a signal with a significance of 6 sigma for the combined Ds and Ds* modes and find the first evidence of the B- -> Ds+ K- l- nubar decay with a significance of 3.4 sigma. We measure the following branching fractions: BF(B- -> Ds+ K- l nubar) = (0.30 +/- 0.09(stat) +0.11 -0.08(syst)) x 10^-3 and BF(B- -> Ds*+ K- l- nubar) = (0.59 +/- 0.12(stat) +/- 0.15(syst)) x 10^-3 and set an upper limit BF(B- -> Ds*+ K- l- nubar) < 0.56 x 10^-3 at the 90% confidence level. We also present the first measurement of the Ds+K- invariant mass distribution in these decays, which is dominated by a prominent peak around 2.6 GeV/c^2.Comment: Submitted to Phys. Rev.

Measurements of time-dependent CP asymmetries in B→D∗∓π±B \to D^{*\mp} \pi^{\pm} decays using a partial reconstruction technique

We report results on time-dependent CP asymmetries in $B \to D^{*\mp}\pi^{\pm}$ decays based on a data sample containing 657 {\times} $10^6$ $B\bar{B}$ pairs collected with the Belle detector at the KEKB asymmetric-energy $e^+ e^-$ collider at the $\Upsilon(4S)$ resonance. We use a partial reconstruction technique, wherein signal $B \to D^{*\mp}\pi^{\pm}$ events are identified using information only from the fast pion from the B decay and the slow pion from the subsequent decay of the $D^{*\mp}$, where the former (latter) corresponds to $D^{*+} (D^{*-})$ final states. We obtain CP violation parameters $S^+ = +0.061 \pm 0.018(\mathrm{stat}) \pm 0.012(\mathrm{syst})$ and $S^- = +0.031 \pm 0.019(\mathrm{stat}) \pm 0.015(\mathrm{syst})$.Comment: 8 pages, 5 figures, 2 tables, submitted to Physical Review D (RC

Observation of Bs0→J/ψf0(980)B_s^0\to J/\psi f_0(980) and Evidence for Bs0→J/ψf0(1370)B_s^0\to J/\psi f_0(1370)

We report the first observation of $B_s^0\to J/\psi f_0(980)$ and first evidence for $B_s^0\to J/\psi f_0(1370)$, which are CP eigenstate decay modes. These results are obtained from $121.4\;\mathrm{fb}^{-1}$ of data collected at the $\Upsilon(5S)$ resonance with the Belle detector at the KEKB $e^+e^-$ collider. We measure the branching fractions $\mathcal{B}(B_s^0\to J/\psi f_0(980);f_0(980)\to\pi^+\pi^-)=(1.16^{+0.31}_{-0.19}(\mathrm{stat.})^{+0.15}_{-0.17}(\mathrm{syst.})^{+0.26}_{-0.18}(N_{B_s^{(*)}\bar B_s^{(*)}})) \times 10^{-4}$ with a significance of $8.4\sigma$, and $\mathcal{B}(B_s^0\to J/\psi f_0(1370);f_0(1370)\to\pi^+\pi^-)=(0.34^{+0.11}_{-0.14}(\mathrm{stat.})^{+0.03}_{-0.02}(\mathrm{syst.})^{+0.08}_{-0.05}(N_{B_s^{(*)}\bar B_s^{(*)}})) \times 10^{-4}$ with a significance of $4.2\sigma$. The last error listed is due to uncertainty in the number of produced $B_s^{(*)}\bar B_s^{(*)}$ pairs.Comment: 5 pages, 2 figures, 2 tables, published in PR

First study of \eta_c, \eta(1760) and X(1835) production via \eta'\pi^+\pi^- final states in two-photon collisions

The invariant mass spectrum of the \eta' \pi^+ \pi^- final state produced in two-photon collisions is obtained using a 673 fb^{-1} data sample collected in the vicinity of the \Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e^+e^- collider. We observe a clear signal of the \eta_c and measure its mass and width to be M(\eta_c)=(2982.7 +- 1.8(stat) +- 2.2(syst) +- 0.3(model)) MeV/c^2 and \Gamma(\eta_c) = (37.8^{+5.8}_{-5.3}(stat) +- 2.8(syst) +- 1.4(model)) MeV/c^2. The third error is an uncertainty due to possible interference between the \eta_c and a non-resonant component. We also report the first evidence for \eta(1760) decay to \eta' \pi^+ \pi^-; we find two solutions for its parameters, depending on the inclusion or not of the X(1835), whose existence is of marginal significance in our data. From a fit to the mass spectrum using coherent X(1835) and \eta(1760) resonant amplitudes, we set a 90% confidence level upper limit on the product \Gamma_{\gamma\gamma} \BR (\eta' \pi^+ \pi^-) for the X(1835).Comment: 13 pages, 7 figures, submitted to PR

Search for CP Violation in the Decays D0→KS0P0D^0\rightarrow K^0_S P^0

We have searched for CP violation in the decays $D^0\rightarrow K^0_S P^0$ where $P^0$ denotes a neutral pseudo-scalar meson which is either a $\pi^0$, $\eta$, or $\eta'$ using KEKB asymmetric-energy $e^+e^-$ collision data corresponding to an integrated luminosity of 791 fb$^{-1}$ collected with the Belle detector. No evidence of significant CP violation is observed. We report the most precise CP asymmetry measurement in the decay $D^0\rightarrow K^0_S\pi^0$ to date: $A_{CP}^{D^0\rightarrow K^0_S\pi^0}=(-0.28\pm0.19\pm0.10)$. We also report the first measurements of CP asymmetries in the decays $D^0\rightarrow K^0_S\eta$ and $D^0\rightarrow K^0_S\eta'$: $A_{CP}^{D^0\rightarrow K^0_S\eta}=(+0.54\pm0.51\pm0.16)$ and $A_{CP}^{D^0\rightarrow K^0_S\eta'}=(+0.98\pm0.67\pm0.14)$, respectively

Search for CP Violation in D Meson Decays to phi pi+

We search for CP violation in Cabibbo-suppressed charged D meson decays by measuring the difference between the CP violating asymmetries for the Cabibbo-suppressed decays D+ -> K+K-pi+ and the Cabibbo-favored decays Ds -> K+K-pi+ in the K+K- mass region of the phi resonance. Using 955/fb of data collected with the Belle detector we obtain A_CP(D+ -> phi pi+) = (+0.51 +- 0.28 +- 0.05)%. The measurement improves the sensitivity of previous searches by more than a factor of five. We find no evidence for direct CP violation.Comment: submitted to PR