932 research outputs found
S_3 and the L=1 Baryons in the Quark Model and the Chiral Quark Model
The S_3 symmetry corresponding to permuting the positions of the quarks
within a baryon allows us to study the 70-plet of L=1 baryons without an
explicit choice for the spatial part of the quark wave functions: given a set
of operators with definite transformation properties under the spin-flavor
group SU(3) x SU(2) and under this S_3, the masses of the baryons can be
expressed in terms of a small number of unknown parameters which are fit to the
observed L=1 baryon mass spectrum. This approach is applied to study both the
quark model and chiral constituent quark model. The latter theory leads to a
set of mass perturbations which more satisfactorily fits the observed L=1
baryon mass spectrum (though we can say nothing, within our approach, about the
physical reasonableness of the parameters in the fit). Predictions for the
mixing angles and the unobserved baryon masses are given for both models as
well as a discussion of specific baryons.Comment: 24 pages, requires picte
Comparison of tumour-based (Petersen Index) and inflammation-based (Glasgow Prognostic Score) scoring systems in patients undergoing curative resection for colon cancer
After resection, it is important to identify colon cancer patients, who are at a high risk of recurrence and who may benefit from adjuvant treatment. The Petersen Index (PI), a prognostic model based on pathological criteria is validated in Dukes' B and C disease. Similarly, the modified Glasgow Prognostic Score (mGPS) based on biochemical criteria has also been validated. This study compares both the scores in patients undergoing curative resection of colon cancer. A total of 244 patients underwent elective resection between 1997 and 2005. The PI was constructed from pathological reports; the mGPS was measured pre-operatively. The median follow-up was 67 months (minimum 36 months) during which 109 patients died; 68 of them from cancer. On multivariate analysis of age, Dukes' stage, PI and mGPS, age (hazard ratio, HR, 1.74, P=0.001), Dukes' stage (HR, 3.63, P<0.001), PI (HR, 2.05, P=0.010) and mGPS (HR, 2.34, P<0.001) were associated independently with cancer-specific survival. Three-year cancer-specific survival rates for Dukes' B patients with the low-risk PI were 98, 92 and 82% for the mGPS of 0, 1 and 2, respectively (P<0.05). The high-risk PI population is small, in particular for Dukes' B disease (9%). The mGPS further stratifies those patients classified as low risk by the PI. Combining both the scoring systems could identify patients who have undergone curative surgery but are at high-risk of cancer-related death, therefore guiding management and trial stratification
On the formation of black holes in non-symmetric gravity
It has been recently suggested that the Non-symmetric Gravitational Theory
(NGT) is free of black holes. Here, we study the linear version of NGT. We find
that even with spherical symmetry the skew part of the metric is generally
non-static. In addition, if the skew field is initially regular, it will remain
regular everywhere and, in particular, at the horizon. Therefore, in the
fully-nonlinear theory, if the initial skew-field is sufficiently small, the
formation of a black hole is to be anticipated.Comment: 9 pages, ordinary LaTex
Increased accumulation of sulfur in lake sediments of the high Arctic
Author Posting. © The Author(s), 2010. This is the author's version of the work. It is posted here by permission of American Chemical Society for personal use, not for redistribution. The definitive version was published in Environmental Science & Technology 44 (2010): 8415-8421, doi:10.1021/es101991p.We report a synchronous increase in accumulation of reduced inorganic sulfur since c. 1980 in sediment cores from eight of nine lakes studied in the Canadian Arctic and Svalbard (Norway). Sediment incubations and detailed analyses of sediment profiles from two of the lakes indicate that increases in sulfur accumulation may be due ultimately to a changing climate. Warming-induced lengthening of the ice-free season is resulting in well-documented increases in algal production and sedimentation of the resulting detrital matter. Algal detritus is a rich source of labile carbon, which in these sediments stimulates dissimilatory sulfate reduction. The sulfide produced is stored in sediment (as acid volatile sulfide), converted to other forms of sulfur, or reoxidized to sulfate and lost to the water column. An acceleration of the sulfur cycle in Arctic lakes could have profound effects on important biogeochemical processes, such as carbon burial and mercury methylation.Funding was provided by the WHOI Ocean and Climate Change Institute, the USGS WHOI
Postdoctoral Scholar Program, Environment Canada, the Danmarks Grundforskningsfond, and
the Norges forskningsrÄd (grant number 107745/730)
Relationship between emergency presentation, systemic inflammatory response, and cancer-specific survival in patients undergoing potentially curative surgery for colon cancer
Background
Emergency presentation is recognized to be associated with poorer cancer-specific survival following curative resection for colorectal cancer. The present study examined the hypothesis that an enhanced systemic inflammatory response, prior to surgery, might explain the impact of emergency presentation on survival.
Methods
In all, 188 patients undergoing potentially curative resection for colorectal cancer were studied. Of these, 55 (29%) presented as emergencies. The systemic inflammatory response was assessed using the Glasgow Prognostic Score (mGPS), which is the combination of an elevated C-reactive protein (>10 mg/L) and hypoalbuminemia (<35 g/L).
Results
In the emergency group, tumor stage was greater (P < 0.01), more patients received adjuvant therapy (P < 0.01) more patients had an elevated mGPS (P < 0.01), and more patients died of their disease (P < 0.05). The minimum follow-up was 12 months; the median follow-up of the survivors was 48 months. Emergency presentation was associated with poorer 3-year cancer-specific survival in those patients aged 65 to 74 years (P < 0.01), in both males and females (P < 0.05), in the deprived (P < 0.01), in patients with tumor-node-metastasis (TNM) stage II disease (P < 0.01), in those who received no adjuvant therapy (P < 0.01), and in the mGPS 0 and 1 groups (P < 0.05) groups. On multivariate survival analysis of patients undergoing potentially curative surgery for TNM stage II colon cancer, emergency presentation (P < 0.05) and mGPS (P < 0.05) were independently associated with cancer-specific survival.
Conclusions
These results suggest that emergency presentation and the presence of systemic inflammatory response prior to surgery are linked and account for poorer cancer-specific survival in patients undergoing potentially curative surgery for colon cancer. Both emergency presentation and an elevated mGPS should be taken into account when assessing the likely outcome of these patients
Understanding Terrorist Organizations with a Dynamic Model
Terrorist organizations change over time because of processes such as
recruitment and training as well as counter-terrorism (CT) measures, but the
effects of these processes are typically studied qualitatively and in
separation from each other. Seeking a more quantitative and integrated
understanding, we constructed a simple dynamic model where equations describe
how these processes change an organization's membership. Analysis of the model
yields a number of intuitive as well as novel findings. Most importantly it
becomes possible to predict whether counter-terrorism measures would be
sufficient to defeat the organization. Furthermore, we can prove in general
that an organization would collapse if its strength and its pool of foot
soldiers decline simultaneously. In contrast, a simultaneous decline in its
strength and its pool of leaders is often insufficient and short-termed. These
results and other like them demonstrate the great potential of dynamic models
for informing terrorism scholarship and counter-terrorism policy making.Comment: To appear as Springer Lecture Notes in Computer Science v2:
vectorized 4 figures, fixed two typos, more detailed bibliograph
Preoperative systemic inflammation predicts postoperative infectious complications in patients undergoing curative resection for colorectal cancer
The presence of systemic inflammation before surgery, as evidenced by the glasgow prognostic score (mGPS), predicts poor long-term survival in colorectal cancer. The aim was to examine the relationship between the preoperative mGPS and the development of postoperative complications in patients undergoing potentially curative resection for colorectal cancer. Patients (n=455) who underwent potentially curative resections between 2003 and 2007 were assessed consecutively, and details were recorded in a database. The majority of patients presented for elective surgery (85%) were over the age of 65 years (70%), were male (58%), were deprived (53%), and had TNM stage I/II disease (61%), had preoperative haemoglobin (56%), white cell count (87%) and mGPS 0 (58%) in the normal range. After surgery, 86 (19%) patients developed a postoperative complication; 70 (81%) of which were infectious complications. On multivariate analysis, peritoneal soiling (P<0.01), elevated preoperative white cell count (P<0.05) and mGPS (P<0.01) were independently associated with increased risk of developing a postoperative infection. In elective patients, only the mGPS (OR=1.75, 95% CI=1.17-2.63, P=0.007) was significantly associated with increased risk of developing a postoperative infection. Preoperative elevated mGPS predicts increased postoperative infectious complications in patients undergoing potentially curative resection for colorectal cancer
The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis
Acknowledgements We wish to thank Jorge GalĂĄn, Gregory Pazour, Derek Toomre, Giuliano Callaini, Joel Rosenbaum, Alessandra Boletta and Francesco Blasi for generously providing reagents and for productive discussions, and Sonia Grassini for technical assistance. The work was carried out with the financial support of Telethon (GGP11021) and AIRC.Peer reviewedPostprin
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