Open Device Lab como una estrategia para mejorar la experiencia de aprendizaje de estudiantes de pregrado / posgrado en relación a la garantía de calidad de software y usabilidad para dispositivos móviles.

Los laboratorios de dispositivos abiertos son unrecurso en el que los usuarios pueden probar susaplicaciones en una gama cada vez mayor de dispositivosconectados a Internet. La garantía de calidaden dispositivos reales es una necesidad paragarantizar una experiencia de usuario agradable.Desde una perspectiva educativa, el objetivo delInstituto de tecnología Tralee es proporcionar asus estudiantes las habilidades necesarias para convertirse en desarrolladores de software competentes.Esto requiere que aprecien la experienciade los usuarios finales. Este documento analiza eluso de un ODL para mejorar el aprendizaje de losestudiantes a partir del aseguramiento de la calidady las perspectivas de usabilidad

Current and Future Treatment of Mucopolysaccharidosis (MPS) Type II: Is Brain-Targeted Stem Cell Gene Therapy the Solution for This Devastating Disorder?

Mucopolysaccharidosis type II (Hunter Syndrome) is a rare, x-linked recessive, progressive, multi-system, lysosomal storage disease caused by the deficiency of iduronate-2-sulfatase (IDS), which leads to the pathological storage of glycosaminoglycans in nearly all cell types, tissues and organs. The condition is clinically heterogeneous, and most patients present with a progressive, multi-system disease in their early years. This article outlines the pathology of the disorder and current treatment strategies, including a detailed review of haematopoietic stem cell transplant outcomes for MPSII. We then discuss haematopoietic stem cell gene therapy and how this can be employed for treatment of the disorder. We consider how preclinical innovations, including novel brain-targeted techniques, can be incorporated into stem cell gene therapy approaches to mitigate the neuropathological consequences of the condition

Self-Reported Purchasing Behaviour, Sociodemographic Predictors of Plant-Based Protein Purchasing and Knowledge about Protein in Scotland and England

Acknowledgments: Support for initial data analysis was given by Mary Kynn. Funding: The authors gratefully acknowledge funding from the Scottish Government from project B7-01 (2022–2027), supporting this work.Peer reviewedPublisher PD

Effect of High-Protein Breakfast Meals on Within-Day Appetite and Food Intake in Healthy Men and Women

The Rowett Institute and Biomathematics and Statistics Scotland are grateful to the Scottish Government for funding this work. We thank the Rowett Human Nutrition Unit staff for their technical help with the interventions. Staff members who helped include Jean Bryce, Nina Lamza and Karen Taylor. The Rowett Institute and Biomathematics and Statistics Scotland are grateful to the Scottish Government for funding this work.Peer reviewedPublisher PD

Stroke awareness in the general population: knowledge of stroke risk factors and warning signs in older adults

<p>Abstract</p> <p>Background</p> <p>Stroke is a leading cause of death and functional impairment. While older people are particularly vulnerable to stroke, research suggests that they have the poorest awareness of stroke warning signs and risk factors. This study examined knowledge of stroke warning signs and risk factors among community-dwelling older adults.</p> <p>Methods</p> <p>Randomly selected community-dwelling older people (aged 65+) in Ireland (n = 2,033; 68% response rate). Participants completed home interviews. Questions assessed knowledge of stroke warning signs and risk factors, and personal risk factors for stroke.</p> <p>Results</p> <p>Of the overall sample, 6% had previously experienced a stroke or transient ischaemic attack. When asked to identify stroke risk factors from a provided list, less than half of the overall sample identified established risk factors (e.g., smoking, hypercholesterolaemia), hypertension being the only exception (identified by 74%). Similarly, less than half identified established warning signs (e.g., weakness, headache), with slurred speech (54%) as the exception. Overall, there were considerable gaps in awareness with poorest levels evident in those with primary level education only and in those living in Northern Ireland (compared with Republic of Ireland).</p> <p>Conclusion</p> <p>Knowledge deficits in this study suggest that most of the common early symptoms or signs of stroke were recognized as such by less than half of the older adults surveyed. As such, many older adults may not recognise early symptoms of stroke in themselves or others. Thus, they may lose vital time in presenting for medical attention. Lack of public awareness about stroke warning signs and risk factors must be addressed as one important contribution to reducing mortality and morbidity from stroke.</p

Advancing play participation for all: The challenge of addressing play diversity and inclusion in community parks and playgrounds

Introduction: Outdoor parks and playgrounds are important sites of social inclusion in many urban communities. However, these playspaces are often inaccessible and unusable for many children with disabilities. This paper presents findings from a case study of one urban municipality in Ireland. The study aimed to understand play participation in five local playgrounds by exploring the perspectives of play providers and families with diverse abilities, through the lens of universal design. Methods: Multiple qualitative methods were used, including playground audits, walk-and-talk observations, and semi-structured interviews. Four play providers, 12 children, and 10 adult users took part. Inductive analysis was conducted to understand the usability and accessibility of playgrounds from a universal design perspective. Findings: These playgrounds provided high play value for younger children, but low play value for older children and those with disabilities, due to lack of accessibility or usability. While local authorities aimed to provide inclusive playgrounds, they lacked knowledge on universal design for playspaces. Conclusion: Children with disabilities continue to experience exclusion in community playspaces, despite a commitment to inclusion in local authorities. Play providers need support to tailor principles of universal design to playground design. Occupational therapists are ideally situated to collaborate with local authorities on universal design for enhancing children's play participation in community settings

Daily Fermented Whey Consumption Alters the Fecal Short-Chain Fatty Acid Profile in Healthy Adults

FUNDING: This study was funded by A.Vogel Bioforce AG, Roggwil, Switzerland. NS was co-funded by the School of Medicine, Medical Sciences and Nutrition (University of Aberdeen) and A.Vogel Bioforce AG. The Rowett Institute (University of Aberdeen) receives financial support from the Scottish Government Rural and Environmental Sciences and Analytical Services (RESAS). ACKNOWLEDGMENTS: We thank all the volunteers which contributed their time and efforts into enrolling and completing the trial. Further, we are grateful for the staff at the Human Nutrition Unit and Analytical Services at the Rowett Institute for supporting the research and assisting when needed. We would like to thank Brennan Martin at the Center for Genome Enabled Biology of Medicine for his assistance in DNA sequencingPeer reviewedPublisher PD