5,166 research outputs found
Recommended from our members
Extreme H isotopic anomalies in chondritic organic matter
Extract from introduction: We have conducted ionprobe (IMS6f and NanoSIMS) imaging studies of various samples for H, D, C, 14N and 15N. These will ultimately be correlated with micro-analytic techniques such as FIB/TEM or STXM/XANES. We analyzed matrix fragments from Bells (CM2), Al Rais (CR2) and Tagish Lake (unique) [2], high purity insoluble organic matter (IOM) [3] extracted from EET92042 (“EET”, CR2), Bells, Murchison (CM2), Allende (CV3), Krymka (LL3.1) and, for comparison, 3 IDPs
Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis.
Background: Recent evidence suggests that distinction
of subsets of rheumatoid arthritis (RA) depending on anticyclic
citrullinated peptide antibody (anti-CCP) status may
be helpful in distinguishing distinct aetiopathologies and in
predicting the course of disease. HLA-DRB1 shared
epitope (SE) and peptidylarginine deiminase type 4
(PADI4) genotype, both of which have been implicated in
anti-CCP generation, are assumed to be associated with
RA.
Objectives: To elucidate whether PADI4 affects the
clinical characteristics of RA, and whether it would
modulate the effect of anti-CCPs on clinical course. The
combined effect of SE and PADI4 on autoantibody profile
was also analysed.
Methods: 373 patients with RA were studied. SE,
padi4_94C.T, rheumatoid factor, anti-CCPs and antinuclear
antibodies (ANAs) were determined. Disease
severity was characterised by cumulative therapy
intensity classified into ordinal categories (CTI-1 to CTI-3)
and by Steinbrocker score.
Results: CTI was significantly associated with disease
duration, erosive disease, disease activity score (DAS) 28
and anti-CCPs. The association of anti-CCPs with CTI was
considerably influenced by padi4_94C.T genotype (C/C:
ORadj=0.93, padj=0.92; C/T: ORadj=2.92,
padj=0.093; T/T: ORadj=15.3, padj=0.002). Carriage of
padi4_94T exhibited a significant trend towards higher
Steinbrocker scores in univariate and multivariate
analyses. An association of padi4_94C.T with ANAs
was observed, with noteworthy differences depending on
SE status (SE2: ORadj=6.20, padj,0.04; SE+:
ORadj=0.36, padj=0.02) and significant heterogeneity
between the two SE strata (p=0.006).
Conclusions: PADI4 genotype in combination with anti-
CCPs and SE modulates clinical and serological characteristics
of RA
Charge Fluctuations in the Edge States of N-S hybrid Nano-Structures
In this work we show how to calculate the equilibrium and non-equilibrium
charge fluctuations in a gated normal mesoscopic conductor which is attached to
one normal lead and one superconducting lead. We then consider an example where
the structure is placed in a high magnetic field, such that the transport is
dominated by edge states. We calculate the equilibrium and non-equilibrium
charge fluctuations in the gate, for a single edge state, comparing our results
to those for the same system, but with two normal leads. We then consider the
specific example of a quantum point contact and calculate the charge
fluctuations in the gate for more than one edge state.Comment: 4 pages with 1 figure. In published version the high magnetic field
dynamics of the holes is treated incorrectly. An erratum is in preparatio
Recommended from our members
Were Presolar Grains Destroyed by the Nebular Process Responsible for the Volatile Element Fractionation?
We present SiC abundances from a number of CM and CR chondrites using NanoSIMS raster ion imaging of acid residues. We find higher SiC abundances for CRs than previously estimated based on noble gases
Leveraging multilingual descriptions for link prediction: Initial experiments
In most Knowledge Graphs (KGs), textual descriptions ofentities are provided in multiple natural languages. Additional informa-tion that is not explicitly represented in the structured part of the KGmight be available in these textual descriptions. Link prediction modelswhich make use of entity descriptions usually consider only one language.However, descriptions given in multiple languages may provide comple-mentary information which should be taken into consideration for thetasks such as link prediction. In this poster paper, the benefits of mul-tilingual embeddings for incorporating multilingual entity descriptionsinto the task of link prediction in KGs are investigate
Why Matrix theory works for oddly shaped membranes
We give a simple proof of why there is a Matrix theory approximation for a
membrane shaped like an arbitrary Riemann surface. As corollaries, we show that
noncompact membranes cannot be approximated by matrices and that the Poisson
algebra on any compact phase space is U(infinity). The matrix approximation
does not appear to work properly in theories such as IIB string theory or
bosonic membrane theory where there is no conserved 3-form charge to which the
membranes couple.Comment: 8 pages, 4 figures, revtex; references adde
The Calogero-Moser equation system and the ensemble average in the Gaussian ensembles
From random matrix theory it is known that for special values of the coupling
constant the Calogero-Moser (CM) equation system is nothing but the radial part
of a generalized harmonic oscillator Schroedinger equation. This allows an
immediate construction of the solutions by means of a Rodriguez relation. The
results are easily generalized to arbitrary values of the coupling constant. By
this the CM equations become nearly trivial.
As an application an expansion for in terms of eigenfunctions of
the CM equation system is obtained, where X and Y are matrices taken from one
of the Gaussian ensembles, and the brackets denote an average over the angular
variables.Comment: accepted by J. Phys.
Ordinary differential equations which linearize on differentiation
In this short note we discuss ordinary differential equations which linearize
upon one (or more) differentiations. Although the subject is fairly elementary,
equations of this type arise naturally in the context of integrable systems.Comment: 9 page
- …