Alien Registration- Hooper, Walter H. (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/22056/thumbnail.jp

Reminiscences

Text of a talk at Mythcon VI by Walter Hooper, who worked for C.S. Lewis as his secretary for some time

Usefulness of the Paralens™ Fluorescent Microscope Adaptor for the Identification of Mycobacteria in Both Field and Laboratory Settings

The presence of acid-fast bacilli (AFB) in laboratories has traditionally been demonstrated using the fluorochrome method, which requires a fluorescent microscope or the Ziehl-Neelsen (ZN) method employing light microscopy. Low sensitivity of the ZN method and high costs of fluoroscopy make the need for a more effective means of diagnosis a top priority, especially in developing countries where the burden of tuberculosis is high. The QBC ParaLens™ attachment (QBC Diagnostic Inc., Port Matilda, PA) is a substitute for conventional fluoroscopy in the identification of AFB. To evaluate the efficacy of the ParaLens LED (light-emitting diode) system, the authors performed a two-part study, looking at usefulness, functionality and durability in urban/rural health clinics around the world, as well as in a controlled state public health laboratory setting. In the field, the ParaLens was durable and functioned well with various power sources and lighting conditions. Results from the state laboratory indicated agreement between standard fluorescent microscopy and fluorescent microscopy using the ParaLens. This adaptor is a welcome addition to laboratories in resource-limited settings as a useful alternative to conventional fluoroscopy for detection of mycobacterial species

Flamingo Vol. I N 1

Anonymous. Untitled. Prose. 1. DKF. Untitled. Picture. 3. Holt, Kilburn. Untitled. Poem. 4. Anonymous. An Ancient Reporter . Prose. 5. Anonymous. The Neophyte\u27s Prayer . Poem. 6. Anonymous. Gone-But Not Forgotten . Poem. 6. R.D.B. Untitled. Picture. 6. Anonymous. Untitled. Prose. 6. Anonymous. Thrice Weekly . Prose. 7. Anonymous. Yus! . Prose. 7. Anonymous. \u27S Truth! . Prose. 8. Anonymous. Tick-Tock: A Calamietta . Prose. 8. Holt, Kilburn. Spring . Poem. 9. Anonymous. Untitled. Poem. 9. Anonymous. Which best Applies . Poem. 9. R.D.B. Untitled. Picture. 9. Anonymous. The Circular Hunt of 1823 . Prose. 9. Anonymous. Sad-But True . Poem. 10. Bovington. Sad - But True . Cartoon. 10. Anonymous. Going to the Farm . Prose. 11. Anonymous. Untitled. Picture. 12. Anonymous. Untitled. Poem. 12. Anonymous. \u27Twas Ever Thus . Prose. 12. A.F.T. Two Triolets . Poem. 13. Anonymous. Santa Claus Opens a Factory In Granville . Prose. 13. Anonymous. Untitled. Picture. 14. Anonymous. Untitled. Poem. 14. Anonymous. So Would We . Poem. 14. Anonymous. The Sequence of Love . Poem. 14. Anonymous. A Letter From the Sem-And A Heartless Reply . Prose. 15. Anonymous. Galoshes . Poem. 15. Anonymous. Untitled. Poem. 15. Dickerman, C.H. A Chaucer . Poem. 13. Funk, Dorothy K. Untitled. Picture. 8. Anonymous. Untitled. Prose. 16. Anonymous. Add Horrors of War . Poem. 17. Hooper, Osman C. The Song of The Spring . Poem. 18. Flory, Walter L. The Daily Struggle . Poem. 18. Flory, Walter L. Exasperation . Poem. 18. MacCune, Julia Hall. On Sugar Loaf . Poem. 18. LaRue, Fred S. Behind The Gym . Poem. 18. Anonymous. Untitled. Picture. 19. Anonymous. The Red Rag Doll . Poem. 19. Anonymous. You Say It Is! . Poem. 19. Anonymous. Untitled. Poem. 19. Anonymous. Denison\u27s Hall of Fame . Poem. 20. Holt, Kilburn. Tempus Fugit . Poem. 21. Anonymous. Untitled. Prose. 21. Widow. The War Game . Prose. 21. Anonymous. Untitled. Picture. 21. Widow. Ah! Cribbing! . Poem. 22. Widow. Imposition . Poem. 22. Widow. Untitled. Prose. 22. Orange Peel. Untitled. Prose. 22. Record. Untitled. Prose. 22. Awgwan. Untitled. Prose. 22. Purple Cow. Untitled. Prose. 22. Anonymous. Chapel Singing School . Poem. 23. Anonymous. Untitled. Prose. 24. Anonymous. Three Types of Villain . Prose. 25. Orange Peel. To a Pencil . Poem. 27. Jester. What Men Like in Women . Prose. 27. Burr. Untitled. Poem. 27. Wampus. Untitled. Prose. 27. Anonymous. Untitled. Prose. 27. Judge. Spare Her Blushes . Prose. 27. Awgwan. Untitled. Poem. 27. Tiger. Untitled. Poem. 27. Tiger. Untitled. Poem. 29. Widow. Untitled. Prose. 29. Orange Peel. Untitled. Prose. 29. Anonymous. Low Cut . Prose. 29. Jester. Fine! Fine! . Prose. 29. Chaparal. Untitled. Prose. 31. Sun Dodger. All In The Type . Prose. 31. Orange Peel. Untitled. Prose. 31. Voo-Doo. Untitled. Prose. 31. Jester. Hot Stuff . Prose. 32. Orange Peel. Untitled. Prose. 32. Virginia Reel. Untitled. Prose. 32. Burr. Untitled. Prose. 32. Tiger. Untitled. Prose. 32. Keeler, Clyde. Untitled. Picture. 15 Keeler, Clyde. Untitled. Picture. 23

An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba dictyostelium discoideum

Mutations in either of two presenilin genes can cause familial Alzheimer's disease. Presenilins have both proteolysis-dependent functions, as components of the γ-secretase complex, and proteolysis-independent functions in signalling. In this study, we investigate a conserved function of human presenilins in the development of the simple model organism Dictyostelium discoideum. We show that the block in Dictyostelium development caused by the ablation of both Dictyostelium presenilins is rescued by the expression of human presenilin 1, restoring the terminal differentiation of multiple cell types. This developmental role is independent of proteolytic activity, because the mutation of both catalytic aspartates does not affect presenilin ability to rescue development, and the ablation of nicastrin, a γ-secretase component that is crucial for proteolytic activity, does not block development. The role of presenilins during Dictyostelium development is therefore independent of their proteolytic activity. However, presenilin loss in Dictyostelium results in elevated cyclic AMP (cAMP) levels and enhanced stimulation-induced calcium release, suggesting that presenilins regulate these intracellular signalling pathways. Our data suggest that presenilin proteins perform an ancient non-proteolytic role in regulating intracellular signalling and development, and that Dictyostelium is a useful model for analysing human presenilin function

Failure to detect mutations in U2AF1 due to changes in the GRCh38 reference sequence

The U2AF1 gene is a core part of mRNA splicing machinery and frequently contains somatic mutations that contribute to oncogenesis in myelodysplastic syndrome, acute myeloid leukemia, and other cancers. A change introduced in the GRCh38 version of the human reference build prevents detection of mutations in this gene, and others, by variant calling pipelines. This study describes the problem in detail and shows that a modified GRCh38 reference build with unchanged coordinates can be used to ameliorate the issue

The Far-Infrared Spectral Energy Distributions of X-ray-selected Active Galaxies

[Abridged] We present ISO far-infrared (IR) observations of 21 hard X-ray selected AGN from the HEAO-1 A2 sample. We compare the far-IR to X-ray spectral energy distributions (SEDs) of this sample with various radio and optically selected AGN samples. The hard-X-ray selected sample shows a wider range of optical/UV shapes extending to redder near-IR colors. The bluer objects are Seyfert 1s, while the redder AGN are mostly intermediate or type 2 Seyferts. This is consistent with a modified unification model in which the amount of obscuring material increases with viewing angle and may be clumpy. Such a scenario, already suggested by differing optical/near-IR spectroscopic and X-ray AGN classifications, allows for different amounts of obscuration of the continuum emission in different wavebands and of the broad emission line region which results in a mixture of behaviors for AGN with similar optical emission line classifications. The resulting limits on the column density of obscuring material through which we are viewing the redder AGN are 100 times lower than for the standard optically thick torus models. The resulting decrease in optical depth of the obscuring material allows the AGN to heat more dust at larger radial distances. We show that an AGN-heated, flared, dusty disk with mass 10^9 solar and size of few hundred pc is able to generate optical-far-IR SEDs which reproduce the wide range of SEDs present in our sample with no need for an additional starburst component to generate the long-wavelength, cooler part of the IR continuum.Comment: 40 pages, 14 figures, accepted for publication in Astrophysical Journal, V. 590, June 10, 200