462 research outputs found
Dopamine-neurotransmission and nociception in zebrafish: An anti-nociceptive role of dopamine receptor drd2a
Dopamine (DA) is an important modulator in nociception and analgesia. Spinal DA receptors are involved in descending modulation of the nociceptive transmission. Genetic variations within DA neurotransmission have been associated with altered pain sensitivity and development of chronic pain syndromes. The variant rs6277 in dopamine receptor 2 a (drd2a) has been associated with a decreased D2 receptor availability and increased nociception. The aim of this study is to further characterize the role of DA neurotransmission in nociception and the anti-nociceptive function of drd2a. The phenotype caused by rs6277 was modelled in zebrafish larvae using morpholino's and the effect on nociception was tested using a validated behavioural assay. The anti-nociceptive role of drd2a was tested using pharmacological intervention of D2 agonist Quinpirole. The experiments demonstrate that a decrease in drd2a expression results in a pro-nociceptive behavioural phenotype (P = 0.016) after a heat stimulus. Furthermore, agonism of drd2a with agonist Quinpirole (0.2 mu M) results in dose-dependent anti-nociception (P = 0.035) after a heat stimulus. From these results it is concluded that the dopamine receptor drd2a is involved in anti-nociceptive behaviour in zebrafish. The model allows further screening and testing of genetic variation and treatment involved in nociception
Dynamics of Generalized Assisted Inflation
We study the dynamics of multiple scalar fields and a barotropic fluid in an
FLRW-universe. The scalar potential is a sum of exponentials. All critical
points are constructed and these include scaling and de Sitter solutions. A
stability analysis of the critical points is performed for generalized assisted
inflation, which is an extension of assisted inflation where the fields
mutually interact. Effects in generalized assisted inflation which differ from
assisted inflation are emphasized. One such a difference is that an
(inflationary) attractor can exist if some of the exponential terms in the
potential are negative.Comment: 27 page
Scalar Field Cosmologies with Barotropic Matter: Models of Bianchi class B
We investigate in detail the qualitative behaviour of the class of Bianchi
type B spatially homogeneous cosmological models in which the matter content is
composed of two non-interacting components; the first component is described by
a barotropic fluid having a gamma-law equation of state, whilst the second is a
non-interacting scalar field (phi) with an exponential potential V=Lambda exp(k
phi). In particular, we study the asymptotic properties of the models both at
early and late times, paying particular attention on whether the models
isotropize (and inflate) to the future, and we discuss the genericity of the
cosmological scaling solutions.Comment: 18 pages, 1 figure, uses revtex and epsf to insert figur
Self-similar spherically symmetric cosmological models with a perfect fluid and a scalar field
Self-similar, spherically symmetric cosmological models with a perfect fluid
and a scalar field with an exponential potential are investigated. New
variables are defined which lead to a compact state space, and dynamical
systems methods are utilised to analyse the models. Due to the existence of
monotone functions global dynamical results can be deduced. In particular, all
of the future and past attractors for these models are obtained and the global
results are discussed. The essential physical results are that initially
expanding models always evolve away from a massless scalar field model with an
initial singularity and, depending on the parameters of the models, either
recollapse to a second singularity or expand forever towards a flat power-law
inflationary model. The special cases in which there is no barotropic fluid and
in which the scalar field is massless are considered in more detail in order to
illustrate the asymptotic results. Some phase portraits are presented and the
intermediate dynamics and hence the physical properties of the models are
discussed.Comment: 31 pages, 4 figure
Local and non-local measures of acceleration in cosmology
Current cosmological observations, when interpreted within the framework of a
homogeneous and isotropic Friedmann-Lemaitre-Robertson-Walker (FLRW) model,
strongly suggest that the Universe is entering a period of accelerating
expansion. This is often taken to mean that the expansion of space itself is
accelerating. In a general spacetime, however, this is not necessarily true. We
attempt to clarify this point by considering a handful of local and non-local
measures of acceleration in a variety of inhomogeneous cosmological models.
Each of the chosen measures corresponds to a theoretical or observational
procedure that has previously been used to study acceleration in cosmology, and
all measures reduce to the same quantity in the limit of exact spatial
homogeneity and isotropy. In statistically homogeneous and isotropic
spacetimes, we find that the acceleration inferred from observations of the
distance-redshift relation is closely related to the acceleration of the
spatially averaged universe, but does not necessarily bear any resemblance to
the average of the local acceleration of spacetime itself. For inhomogeneous
spacetimes that do not display statistical homogeneity and isotropy, however,
we find little correlation between acceleration inferred from observations and
the acceleration of the averaged spacetime. This shows that observations made
in an inhomogeneous universe can imply acceleration without the existence of
dark energy.Comment: 19 pages, 10 figures. Several references added or amended, some minor
clarifications made in the tex
Phage display as a tool to study human autoantibodies and autoantigens in systemic autoimmune disease. Selection of recombinant (auto)-antibodies specific for human autoantigens in rheumatic disease (RA, SLE, SSc) from human autoimmune-patient and immunized chicken derived phage display libraries
Closed cosmologies with a perfect fluid and a scalar field
Closed, spatially homogeneous cosmological models with a perfect fluid and a
scalar field with exponential potential are investigated, using dynamical
systems methods. First, we consider the closed Friedmann-Robertson-Walker
models, discussing the global dynamics in detail. Next, we investigate
Kantowski-Sachs models, for which the future and past attractors are
determined. The global asymptotic behaviour of both the
Friedmann-Robertson-Walker and the Kantowski-Sachs models is that they either
expand from an initial singularity, reach a maximum expansion and thereafter
recollapse to a final singularity (for all values of the potential parameter
kappa), or else they expand forever towards a flat power-law inflationary
solution (when kappa^2<2). As an illustration of the intermediate dynamical
behaviour of the Kantowski-Sachs models, we examine the cases of no barotropic
fluid, and of a massless scalar field in detail. We also briefly discuss
Bianchi type IX models.Comment: 15 pages, 10 figure
Do I-Pass for FAIR?:A self-assessment tool to measure the FAIR-ness of an organization
The 15 FAIR data principles are intended to be applied to a dataset, but the acronym FAIR is also used as an adjective for other (digital) matters, such as FAIR data stewardship, FAIR data infrastructure and FAIR data services. Moreover, in the context of Open Science and scientific integrity, more and more Dutch universities and research organizations discuss a FAIR organization as an important goal, thus implementing RDM practices and support with the FAIR principles as a main driver.
Triggered by this use of the acronym FAIR for organizations, an LCRDM (National Coordination Point Research Data Management) task group explored the definition, characteristics and principles of a so-called âFAIR enabling organizationâ. The task group delivered two products: (1) a definition for a FAIR enabling organization and (2) a self-assessment tool to evaluate the FAIR-ness of a research organization (research institute, university or university of applied sciences).
This self-assessment tool is a simple instrument, presented in an editable PDF form. By answering the questions and evaluating the level (beginner, intermediate, or advanced) at which you assess the performance of your organization, you will be able to define the actual FAIR-ness. In addition you can define a Road Map to become a FAIR Enabling Research Organization using the information in de more advances level(s)
Irreversible Processes in Inflationary Cosmological Models
By using the thermodynamic theory of irreversible processes and Einstein
general relativity, a cosmological model is proposed where the early universe
is considered as a mixture of a scalar field with a matter field. The scalar
field refers to the inflaton while the matter field to the classical particles.
The irreversibility is related to a particle production process at the expense
of the gravitational energy and of the inflaton energy. The particle production
process is represented by a non-equilibrium pressure in the energy-momentum
tensor. The non-equilibrium pressure is proportional to the Hubble parameter
and its proportionality factor is identified with the coefficient of bulk
viscosity. The dynamic equations of the inflaton and the Einstein field
equations determine the time evolution of the cosmic scale factor, the Hubble
parameter, the acceleration and of the energy densities of the inflaton and
matter. Among other results it is shown that in some regimes the acceleration
is positive which simulates an inflation. Moreover, the acceleration decreases
and tends to zero in the instant of time where the energy density of matter
attains its maximum value.Comment: 13 pages, 2 figures, to appear in PR
Renormalization Group Approach to Generalized Cosmological models
We revisit here the problem of generalized cosmology using renormalization
group approach. A complete analysis of these cosmologies, where specific models
appear as asymptotic fixed-points, is given here along with their linearized
stability analysis.Comment: 10 pages, to appear in the International Journal of Theoretical
Physic
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