The Health and Health Care of People with Intellectual Disabilities

New research studies conducted by Special Olympics found disturbing evidence that individuals with intellectual disabilities face widespread health problems, while physicians, dentists and other health professionals are not receiving adequate training in order to treat them. The research reinforces previous studies that found that despite the widespread belief that individuals with intellectual disabilities receive better health care than the rest of the population, people with intellectual disabilities actually have poorer health, more specialized ealth care needs and greater difficulty accessing health care services and doctors compared to the general public.Research Methodology: Special Olympics recently commissioned two research studies related to the health and health care of individuals with intellectual disabilities

Electroblotting onto activated glass. High efficiency preparation of proteins from analytical sodium dodecyl sulfate-polyacrylamide gels for direct sequence analysis

We have developed a new method for the isolation of proteins for microsequencing. It consists of electrophoretic transfer (electroblotting) of proteins or their cleavage fragments onto activated glass filter paper sheets immediately after separation by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The proteins are immobilized on the glass fiber sheets by ionic interactions or by covalent attachment. A wide range of proteins can be prepared in this fashion with no apparent restriction due to solubility, size, charge, or other intrinsic properties of the proteins. As little as 50 ng of the transferred proteins can be detected using Coomassie Blue or fluorescent dye staining procedures and even smaller amounts of radiolabeled proteins by autoradiography. After detection, the protein- containing bands or spots are cut out and inserted directly into a gas- phase sequenator. The piece of glass fiber sheet acts as a support for the protein during the sequencing. Amounts of protein in the 5- to 150- pmol range can be sequenced, and extended runs can be obtained from the blotted samples because of improved stepwise yields and lower backgrounds. The method has been successfully applied to the sequencing of a variety of proteins and peptides isolated from one-dimensional and two-dimensional polyacrylamide gels

Application of Citizen Science Risk Communication Tools in a Vulnerable Urban Community

IMPACT. 1: The results demonstrated that eight metals occurred at statistically-significantly greater levels than natural background levels, but most were below risk-based residential soil screening levels. -- 2. This study demonstrates that community-led coalitions in collaboration with academic teams and state agencies can effectively address environmental concerns. -- 3. This data when combined with the USEPA EJ Screen tool data for 43207 suggests that the Stambaugh-Elwood community is vulnerable.OSU PARTNERS: School of Environment and Natural Resources; Division of Environmental Health Sciences; Division of Epidemiology; College of Public Health; Center for Clinical and Translational ScienceCOMMUNITY PARTNERS: Columbus Public Health; Ohio-Environmental Protection Agency; Southside Health Advisory Committee; Stambaugh-Elwood Citizens for the Environment; VERTICES, LLC; Universities Space Research Association at NASA, Marshall Space Flight CenterPRIMARY CONTACT: Darryl B. Hood ([email protected])A public participatory geographical information systems (PPGIS) demographic, environmental, socioeconomic, health status portal was developed for the Stambaugh-Elwood community in Columbus, OH. A soil study was conducted at SE residences

Arkansas Cotton Variety Test 2008

The primary goal of the Arkansas Cotton Variety Test is to provide unbiased data regarding the agronomic performance of cotton varieties and advanced breeding lines in the major cotton-growing areas of Arkansas. This information helps seed companies establish marketing strategies and assists producers in choosing varieties to plant

Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis.

Antagonists of alphavbeta3 and alphavbeta5 disrupt angiogenesis in response to bFGF and VEGF, respectively. Here, we show that these alphav integrins differentially contribute to sustained Ras-extracellular signal-related kinase (Ras-ERK) signaling in blood vessels, a requirement for endothelial cell survival and angiogenesis. Inhibition of FAK or alphavbeta5 disrupted VEGF-mediated Ras and c-Raf activity on the chick chorioallantoic membrane, whereas blockade of FAK or integrin alphavbeta3 had no effect on bFGF-mediated Ras activity, but did suppress c-Raf activation. Furthermore, retroviral delivery of active Ras or c-Raf promoted ERK activity and angiogenesis, which anti-alphavbeta5 blocked upstream of Ras, whereas anti-alphavbeta3 blocked downstream of Ras, but upstream of c-Raf. The activation of c-Raf by bFGF/alphavbeta3 not only depended on FAK, but also required p21-activated kinase-dependent phosphorylation of serine 338 on c-Raf, whereas VEGF-mediated c-Raf phosphorylation/activation depended on Src, but not Pak. Thus, integrins alphavbeta3 and alphavbeta5 differentially regulate the Ras-ERK pathway, accounting for distinct vascular responses during two pathways of angiogenesis