SemanticCAP: Chromatin Accessibility Prediction Enhanced by Features Learning from a Language Model

A large number of inorganic and organic compounds are able to bind DNA and form complexes, among which drug-related molecules are important. Chromatin accessibility changes not only directly affects drug-DNA interactions, but also promote or inhibit the expression of critical genes associated with drug resistance by affecting the DNA binding capacity of TFs and transcriptional regulators. However, Biological experimental techniques for measuring it are expensive and time consuming. In recent years, several kinds of computational methods have been proposed to identify accessible regions of the genome. Existing computational models mostly ignore the contextual information of bases in gene sequences. To address these issues, we proposed a new solution named SemanticCAP. It introduces a gene language model which models the context of gene sequences, thus being able to provide an effective representation of a certain site in gene sequences. Basically, we merge the features provided by the gene language model into our chromatin accessibility model. During the process, we designed some methods to make feature fusion smoother. Compared with other systems under public benchmarks, our model proved to have better performance

Age-specific seriousness of avian influenza A(H7N9) in the second-wave epidemic in China

Poster Presentations 2 - Diseases at the Interface of Humans, Wildlife and Other Animals: no. 23.049PURPOSE: In spring 2013, a novel avian influenza A(H7N9) emerged in China causing more than 130 human infections mostly in the eastern provinces. The hospital fatality risk of A(H7N9) were about 35% and caused severe illness especially in older patients. In winter 2013-14, a second wave of A(H7N9) began with higher burden in the southern provinces in China. We estimated the relative risk of serious illness of patients aged 65 or above in the second wave of A(H7N9) epidemic, accounting for potential age-specific differences in poultry exposure …published_or_final_versio

An efficient power plant model of electric vehicles for unit commitment of large scale wind farms

AbstractAn efficient power plant model of electric vehicles (E-EPP) considering the travelling comfort levels of EV users is developed to investigate the contribution of EVs on the unit commitment (UC) of large scale wind farms. Firstly, a generic EV battery model (GEBM) is established considering the uncertainties of battery parameters. Then, a Monte Carlo Simulation (MCS) method is implemented within the E-EPP to obtain the available response capacity of EV charging load over time. And a UC strategy using the E-EPP based on power flow tracing is developed. Finally, a modified IEEE 118-bus system integrated with wind farms is used to verify the effectiveness of the E-EPP for the UC of large scale wind farms

Age-specific seriousness of avian influenza A(H7N9) in the second-wave epidemic in China

Poster Presentations 2 - Diseases at the Interface of Humans, Wildlife and Other Animals: no. 23.049PURPOSE: In spring 2013, a novel avian influenza A(H7N9) emerged in China causing more than 130 human infections mostly in the eastern provinces. The hospital fatality risk of A(H7N9) were about 35% and caused severe illness especially in older patients. In winter 2013-14, a second wave of A(H7N9) began with higher burden in the southern provinces in China. We estimated the relative risk of serious illness of patients aged 65 or above in the second wave of A(H7N9) epidemic, accounting for potential age-specific differences in poultry exposure …published_or_final_versio