12,299 research outputs found
Properties of Catlin's reduced graphs and supereulerian graphs
A graph is called collapsible if for every even subset ,
there is a spanning connected subgraph of such that is the set of
vertices of odd degree in . A graph is the reduction of if it is
obtained from by contracting all the nontrivial collapsible subgraphs. A
graph is reduced if it has no nontrivial collapsible subgraphs. In this paper,
we first prove a few results on the properties of reduced graphs. As an
application, for 3-edge-connected graphs of order with for any where are given, we show how such graphs
change if they have no spanning Eulerian subgraphs when is increased from
to 10 then to
MIMO Channel Information Feedback Using Deep Recurrent Network
In a multiple-input multiple-output (MIMO) system, the availability of
channel state information (CSI) at the transmitter is essential for performance
improvement. Recent convolutional neural network (NN) based techniques show
competitive ability in realizing CSI compression and feedback. By introducing a
new NN architecture, we enhance the accuracy of quantized CSI feedback in MIMO
communications. The proposed NN architecture invokes a module named long
short-term memory (LSTM) which admits the NN to benefit from exploiting
temporal and frequency correlations of wireless channels. Compromising
performance with complexity, we further modify the NN architecture with a
significantly reduced number of parameters to be trained. Finally, experiments
show that the proposed NN architectures achieve better performance in terms of
both CSI compression and recovery accuracy
Inhibition of EGFR nuclear shuttling decreases irradiation resistance in HeLa cells
Introduction. Cervical cancer is a leading cause of mortality in women worldwide. The resistance to irradiation at the advanced stage is the main reason for the poor prognosis and high mortality. This work aims to elucidate the molecular mechanism underlying the radio-resistance.
Material and methods. In this study, we determined the pEGFR-T654 and pDNA-PK-T2609 expression level changes in irradiated HeLa cells treated with T654 peptide, a nuclear localization signal (NLS) inhibitor, to inhibit EGFR nuclear transport. Cell viability, cell cycle and migratory capacity were analyzed. Xenograft animal model was used to evaluate the effect of EGFR nuclear transport inhibition on the tumor growth in vivo.
Results. The enhanced translocation of nuclear EGFR in the irradiated HeLa cells correlated with the increasing level of pEGFR-T654 and pDNA-PK-T2609. Inhibition of EGFR nuclear translocation by NLS peptide inhibitor attenuated DNA damage repair in the irradiated HeLa cells, decreased cell viability and promoted cell death through arrest at G0 phase. NLS peptide inhibitor impaired the migratory capacity of irradiated HeLa cells, and negatively affected tumorigenesis in xenograft mice.
Conclusions. This work puts forward a potential molecular mechanism of the irradiation resistance in cervical cancer cells, providing a promising direction towards an efficient therapy of cervical cancer
Inhibition of EGFR nuclear shuttling decreases irradiation resistance in HeLa cells
Introduction. Cervical cancer is a leading cause of mortality in women worldwide. The resistance to irradiation at the advanced stage is the main reason for the poor prognosis and high mortality. This work aims to elucidate the molecular mechanism underlying the radio-resistance. Material and methods. In this study, we determined the pEGFR-T654 and pDNA-PK-T2609 expression level changes in irradiated HeLa cells treated with T654 peptide, a nuclear localization signal (NLS) inhibitor, to inhibit EGFR nuclear transport. Cell viability, cell cycle and migratory capacity were analyzed. Xenograft animal model was used to evaluate the effect of EGFR nuclear transport inhibition on the tumor growth in vivo. Results. The enhanced translocation of nuclear EGFR in the irradiated HeLa cells correlated with the increasing level of pEGFR-T654 and pDNA-PK-T2609. Inhibition of EGFR nuclear translocation by NLS peptide inhibitor attenuated DNA damage repair in the irradiated HeLa cells, decreased cell viability and promoted cell death through arrest at G0 phase. NLS peptide inhibitor impaired the migratory capacity of irradiated HeLa cells, and negatively affected tumorigenesis in xenograft mice. Conclusions. This work puts forward a potential molecular mechanism of the irradiation resistance in cervical cancer cells, providing a promising direction towards an efficient therapy of cervical cancer. (Folia Histochemica et Cytobiologica 2017, Vol. 55, No. 2, 43–51
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