Low field phase diagram of spin-Hall effect in the mesoscopic regime

When a mesoscopic two dimensional four-terminal Hall cross-bar with Rashba and/or Dresselhaus spin-orbit interaction (SOI) is subjected to a perpendicular uniform magnetic field $B$, both integer quantum Hall effect (IQHE) and mesoscopic spin-Hall effect (MSHE) may exist when disorder strength $W$ in the sample is weak. We have calculated the low field "phase diagram" of MSHE in the $(B,W)$ plane for disordered samples in the IQHE regime. For weak disorder, MSHE conductance $G_{sH}$ and its fluctuations $rms(G_{SH})$ vanish identically on even numbered IQHE plateaus, they have finite values on those odd numbered plateaus induced by SOI, and they have values $G_{SH}=1/2$ and $rms(G_{SH})=0$ on those odd numbered plateaus induced by Zeeman energy. For moderate disorder, the system crosses over into a regime where both $G_{sH}$ and $rms(G_{SH})$ are finite. A larger disorder drives the system into a chaotic regime where $G_{sH}=0$ while $rms(G_{SH})$ is finite. Finally at large disorder both $G_{sH}$ and $rms(G_{SH})$ vanish. We present the physics behind this ``phase diagram".Comment: 4 page, 3 figure

Universal spin-Hall conductance fluctuations in two dimensions

We report a theoretical investigation on spin-Hall conductance fluctuation of disordered four terminal devices in the presence of Rashba or/and Dresselhaus spin-orbital interactions in two dimensions. As a function of disorder, the spin-Hall conductance $G_{sH}$ shows ballistic, diffusive and insulating transport regimes. For given spin-orbit interactions, a universal spin-Hall conductance fluctuation (USCF) is found in the diffusive regime. The value of the USCF depends on the spin-orbit coupling $t_{so}$, but is independent of other system parameters. It is also independent of whether Rashba or Dresselhaus or both spin-orbital interactions are present. When $t_{so}$ is comparable to the hopping energy $t$, the USCF is a universal number $\sim 0.18 e/4\pi$. The distribution of $G_{sH}$ crosses over from a Gaussian distribution in the metallic regime to a non-Gaussian distribution in the insulating regime as the disorder strength is increased.Comment: to be published in Phys. Rev. Lett., 4 figure

Parthenolide attenuates LPS-induced activation of NF-κB in a time-dependent manner in rat myocardium.

Parthenolide (PTN), a selective nuclear factor kappa B (NF-κB) inhibitor, has been used extensively to inhibit NF-κB activation. The duration of the inhibitory effect of PTN on NF-κB in vivo remains unclear. This study was to determine whether a lipopolysaccharide (LPS) challenge 6, 12 and 24 h after the administration of PTN could activate NF-κB. Rats were devided into five groups. The rats in the PTN, PTN+LPS and DMSO groups were injected intraperitoneally with PTN or DMSO. After 6, 12 or 24 h, LPS was administered in LPS and PTN+LPS groups. The expressions of NF-κB p50, IκBα and p-IκBα were inhibited in both PTN and PTN+LPS group at end of 6 and 12 h and no effects at 24 h. In summary, myocardial NF-κB expression occurs 1 h after the administration of LPS. PTN blocks this effect given at 6 h and no inhibitory effect 24 h after administration in vivo

Universal quantized spin-Hall conductance fluctuation in graphene

We report a theoretical investigation of quantized spin-Hall conductance fluctuation of graphene devices in the diffusive regime. Two graphene models that exhibit quantized spin-Hall effect (QSHE) are analyzed. Model-I is with unitary symmetry under an external magnetic field $B\ne 0$ but with zero spin-orbit interaction, $t_{SO}=0$. Model-II is with symplectic symmetry where B=0 but $t_{SO} \ne 0$. Extensive numerical calculations indicate that the two models have exactly the same universal QSHE conductance fluctuation value $0.285 e/4\pi$ regardless of the symmetry. Qualitatively different from the conventional charge and spin universal conductance distributions, in the presence of edge states the spin-Hall conductance shows an one-sided log-normal distribution rather than a Gaussian distribution. Our results strongly suggest that the quantized spin-Hall conductance fluctuation belongs to a new universality class

Anti-arthritic effect of total anthraquinone from Polygonum cuspidatum on type II collagen-induced arthritis in rats

Purpose: To study the anti-arthritic effect of total anthraquinone from Polygonum  cuspidatum (TAPC) on type II collagen-induced arthritis (CIA) in rats, and to  investigate the underlying mechanism(s).Methods: CIA rats were prepared and treated orally with TAPC at doses of 50, 100 and 200 mg/kg/day, for 24 days. Paw volume and arthritis score were measured prior to TAPC treatment, and subsequently at 3-day intervals on days 3, 6, 9, 12, 15, 18, 21 and 24. Serum levels of TNF-α, IL-6 and IL-17 were determined by enzyme-linked immunosorbent assay (ELISA), while synovial tissue TNF-α, IL-6 and IL-17mRNA expressions were assayed by real time-polymerase chain reaction (RT-PCR). Thymus and spleen indices were also determined.Results: TAPC (50, 100 and 200 mg/kg) significantly alleviated paw swelling (p < 0.05), arthritis scores (p < 0.05) and thymus and spleen indices (p < 0.05) of CIA rats, when compared with the control rats. In addition, TAPC significantly decreased serum levels of the pro-inflammatory cytokines TNF-α, IL-6 and IL-17 (p < 0.01); and down-regulated their mRNA expressions in synovial tissues (p < 0.01).Conclusion: These results suggest that TAPC exerts good anti-arthritic activity in rats, most probably via suppression of inflammatory responses.Keywords: Polygonum cuspidatum, Anthraquinone, Type II collagen-induced  arthritis, Pro-inflammatory cytokine