13,417 research outputs found
Locating influential nodes via dynamics-sensitive centrality
With great theoretical and practical significance, locating influential nodes
of complex networks is a promising issues. In this paper, we propose a
dynamics-sensitive (DS) centrality that integrates topological features and
dynamical properties. The DS centrality can be directly applied in locating
influential spreaders. According to the empirical results on four real networks
for both susceptible-infected-recovered (SIR) and susceptible-infected (SI)
spreading models, the DS centrality is much more accurate than degree,
-shell index and eigenvector centrality.Comment: 6 pages, 1 table and 2 figure
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Postsynaptic protein organization revealed by electron microscopy.
Neuronal synapses are key devices for transmitting and processing information in the nervous system. Synaptic plasticity, generally regarded as the cellular basis of learning and memory, involves changes of subcellular structures that take place at the nanoscale. High-resolution imaging methods, especially electron microscopy (EM), have allowed for quantitative analysis of such nanoscale structures in different types of synapses. In particular, the semi-ordered organization of neurotransmitter receptors and their interacting scaffolds in the postsynaptic density have been characterized for both excitatory and inhibitory synapses by studies using various EM techniques such as immuno-EM, electron tomography of high-pressure freezing and freeze-substituted samples, and cryo electron tomography. These techniques, in combination with new correlative approaches, will further facilitate our understanding of the molecular organization underlying diverse functions of neuronal synapses
Re-Study on the wave functions of states in LFQM and the radiative decays of
The Light-front quark model (LFQM) has been applied to calculate the
transition matrix elements of heavy hadron decays. However, it is noted that
using the traditional wave functions of the LFQM given in literature, the
theoretically determined decay constants of the obviously
contradict to the data. It implies that the wave functions must be modified.
Keeping the orthogonality among the states and fitting their decay
constants we obtain a series of the wave functions for . Based on
these wave functions and by analogy to the hydrogen atom, we suggest a modified
analytical form for the wave functions. By use of the modified
wave functions, the obtained decay constants are close to the experimental
data. Then we calculate the rates of radiative decays of . Our predictions are consistent with the experimental data on
decays within the theoretical and experimental
errors.Comment: 10 pages, 2 figures, 1 table. Typos corrected and more discussions
added. accepted for publication in Physical Review
Universal linear-temperature resistivity: possible quantum diffusion transport in strongly correlated superconductors
The strongly correlated electron fluids in high temperature cuprate
superconductors demonstrate an anomalous linear temperature () dependent
resistivity behavior, which persists to a wide temperature range without
exhibiting saturation. As cooling down, those electron fluids lose the
resistivity and condense into the superfluid. However, the origin of the
linear- resistivity behavior and its relationship to the strongly correlated
superconductivity remain a mystery. Here we report a universal relation
, which bridges the slope of the
linear--dependent resistivity () to the London penetration depth
at zero temperature among cuprate superconductor
BiSrCaCuO and heavy fermion superconductors
CeCoIn, where is vacuum permeability, is the Boltzmann
constant and is the reduced Planck constant. We extend this scaling
relation to different systems and found that it holds for other cuprate,
pnictide and heavy fermion superconductors as well, regardless of the
significant differences in the strength of electronic correlations, transport
directions, and doping levels. Our analysis suggests that the scaling relation
in strongly correlated superconductors could be described as a hydrodynamic
diffusive transport, with the diffusion coefficient () approaching the
quantum limit , where is the quasi-particle effective
mass.Comment: 8 pages, 2 figures, 1 tabl
Accumulation of Dense Core Vesicles in Hippocampal Synapses Following Chronic Inactivity.
The morphology and function of neuronal synapses are regulated by neural activity, as manifested in activity-dependent synapse maturation and various forms of synaptic plasticity. Here we employed cryo-electron tomography (cryo-ET) to visualize synaptic ultrastructure in cultured hippocampal neurons and investigated changes in subcellular features in response to chronic inactivity, a paradigm often used for the induction of homeostatic synaptic plasticity. We observed a more than 2-fold increase in the mean number of dense core vesicles (DCVs) in the presynaptic compartment of excitatory synapses and an almost 20-fold increase in the number of DCVs in the presynaptic compartment of inhibitory synapses after 2 days treatment with the voltage-gated sodium channel blocker tetrodotoxin (TTX). Short-term treatment with TTX and the N-methyl-D-aspartate receptor (NMDAR) antagonist amino-5-phosphonovaleric acid (AP5) caused a 3-fold increase in the number of DCVs within 100 nm of the active zone area in excitatory synapses but had no significant effects on the overall number of DCVs. In contrast, there were very few DCVs in the postsynaptic compartments of both synapse types under all conditions. These results are consistent with a role for presynaptic DCVs in activity-dependent synapse maturation. We speculate that these accumulated DCVs can be released upon reactivation and may contribute to homeostatic metaplasticity
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