Multidimensional Taylor Network Optimal Control of MIMO Nonlinear Systems without Models for Tracking by Output Feedback

The actual controlled objects are generally multi-input and multioutput (MIMO) nonlinear systems with imprecise models or even without models, so it is one of the hot topics in the control theory. Due to the complex internal structure, the general control methods without models tend to be based on neural networks. However, the neuron of neural networks includes the exponential function, which contributes to the complexity of calculation, making the neural network control unable to meet the real-time requirements. The newly developed multidimensional Taylor network (MTN) requires only addition and multiplication, so it is easy to realize real-time control. In the present study, the MTN approach is extended to MIMO nonlinear systems without models to realize adaptive output feedback control. The MTN controller is proposed to guarantee the stability of the closed-loop system. Our experimental results show that the output signals of the system are bounded and the tracking error goes nearly to zero. The MTN optimal controller is proven to promise far better real-time dynamic performance and robustness than the BP neural network self-adaption reconstitution controller

Ubiquity, diversity and physiological characteristics of Geodermatophilaceae in Shapotou National Desert Ecological Reserve

The goal of this study was to gain insight into the diversity of culturable actinobacteria in desert soil crusts and to determine the physiological characteristics of the predominant actinobacterial group in these crusts. Culture-dependent method was employed to obtain actinobacterial strains from desert soil samples collected from Shapotou National Desert Ecological Reserve located in Tengger Desert, China. A total of 376 actinobacterial strains were isolated and 16S rRNA gene sequences analysis indicated that these isolates belonged to 29 genera within 18 families, among which the members of the family Geodermatophilaceae were predominant. The combination of 16S rRNA gene information and the phenotypic data allowed these newly-isolated Geodermatophilaceae members to be classified into 33 species clusters, 11 of which represented hitherto unrecognized species. Fermentation broths from 19.7% of the isolated strains showed activity in at least one of the six screens for antibiotic activity. These isolates exhibited bio-diversity in enzymatic characteristics and carbon utilization profiles. The physiological characteristics of the isolates from different types of crusts or bare sand samples were specific to their respective micro-ecological environments. Our study revealed that members of the family Geodermatophilaceae were ubiquitous, abundant, and diverse in Shapotou National Desert Ecological Reserve, and these strains may represent a new major group of potential functional actinobacteria in desert soil

MFV approach to robust estimate of neutron lifetime

Aiming at evaluating the lifetime of the neutron, we introduce a novel statistical method to analyse the updated compilation of precise measurements including the 2022 dataset of Particle Data Group (PDG). Based on the minimization for the information loss principle, unlike the median statistics method, we apply the most frequent value (MFV) procedure to estimate the neutron lifetime, irrespective of the Gaussian or non-Gaussian distributions. Providing a more robust way, the calculated result of the MFV is $\tau_n=881.16^{+2.25}_{-2.35}$ s with statistical bootstrap errors, while the result of median statistics is $\tau_n=881.5^{+5.5}_{-3}$ s according to the binomial distribution. Using the different central estimates, we also construct the error distributions of neutron lifetime measurements and find the non-Gaussianity, which is still meaningful

Dissolution rate enhancement of repaglinide by solid dispersion

Purpose: To enhance the solubility and dissolution rate of the antidiabetic drug repaglinide by solid dispersion (SD) techniqueMethod: The solid dispersion of repaglinide was prepared by solvent evaporation method using the hydrophilic carrier,  polyethylene glycol 4000 (PEG 4000) in three drug:PEG 4000 ratios (1:1, 1:3, 1:5). For comparison, physical mixtures of repaglinide and PEG 4000 in the same ratios were also prepared. The formulations were characterized by Fourier transformed infrared spectroscopy (FTIR), x-ray diffractometry (XRD) and differential scanning colorimetry (DSC). Phase solubility study of pure repaglinide, physical mixture and solid dispersion was performed in distilled water. Dissolution studies were carried out in pH 7.4 phosphate buffer.Results: DSC and XRD results indicate that repaglinide exists in amorphous form in solid dispersion. FT-IR analysis demonstrated the presence of intermolecular hydrogen bonding between repaglinide and PEG 4000 in the solid dispersion. The solubility of pure repaglinide was enhanced from 22.5± 5.0 to 235.5± 5.0 μg/mL in distilled water at 37 0C. Rapid burst release (80 - 86 %) from the solid dispersion formulations was observed within 15 min.Conclusion: The solubility and dissolution rate of repaglinide are enhanced by formulating SDs of repaglinide with PEG 4000. This will likely lead to increase in bioavailability which would be beneficial for better glucose control in diabetic patients.Keywords: Diabetes, Solid dispersion, Repaglinide, Solubility, Dissolution, Burst releas

Cluster-induced aggregation in polyurethane derivatives with multicolour emission and ultra-long organic room temperature phosphorescence

Non-conjugated luminescent polymers (NCLPs) have the advantages of simple synthesis, optical tunability, and excellent processability. However, the underlying luminous mechanism in NCLPs remains obscure and it is a considerable challenge to obtain NCLPs with ultra-long phosphorescence lifetime and multicolour emission simultaneously. In this article, linear polyurethane derivatives (PUs) with cluster-induced aggregation, multicolour luminescence and ultra-long phosphorescence have been prepared by simply adjusting the reaction temperature and the reaction time. DFT calculations and molecular dynamics simulations provide elaborate microstructural information on the PUs. With the synergistic effect of abundant hydrogen bonding interactions, through-space dative bonds, short interatomic contacts and oxygen clusters various luminous clusters are formed. The energy level splitting caused by clusters with different extents of spatial conjugation endows the NCLPs with multicolour clusteroluminescence, promotes intersystem crossing (ISC), and stabilises the triplet excited state, and finally an ultra-long room temperature phosphorescence (RTP) lifetime of 0.45 s is attained. Experimental encryption/decryption models validate the potential of the PUs in information security. The results have important implications for understanding the intrinsic mechanism of unconventional luminescence in the absence of any traditional conjugative units or heavy atom effects, and they provide a new horizon for the strategic design of multicolour luminescence and ultra-long phosphorescence in NCLPs for a range of practical applications

Identification of the Cylindromatosis Tumor-Suppressor Gene Responsible for Multiple Familial Trichoepithelioma

Multiple familial trichoepithelioma (MFT) is an autosomal dominant skin disease characterized by the presence of many small benign tumors with pilar differentiation predominantly on the face. The first locus has been previously mapped to chromosome 9p21, but no gene for MFT has been identified to date. To identify the disease gene in a large Chinese family, we initially performed linkage analysis with microsatellite markers from 9p21, but failed to confirm the linkage to this region. Previous publications showed MFT and familial cylindromatosis (FC) can occur within one family and in a single person. Therefore, we speculated that the cylindromatosis gene (CYLDI gene) responsible for FC may be related to the pathogenesis of MFT. In view of that, we genotyped all available individuals using 11 microsatellite markers spanning the CYLDI gene region at 16q12–q13. We identified the linkage of MFT to this region. Mutation analysis in the CYLDI gene detected a frameshift mutation, designated as c.2355–2358delCAGA. The study firstly identified the cylindromatosis gene responsible for MFT and showed that different mutations of the CYLDI gene can give rise to distinct clinical and histological expression such as FC and MFT

State- and frequency-dependence in autonomic rebalance mediated by intradermal auricular electroacupuncture stimulation

BackgroundVagus nerve stimulation (VNS) improves diseases such as refractory epilepsy and treatment-resistant depression, likely by rebalancing the autonomic nervous system (ANS). Intradermal auricular electro-acupuncture stimulation (iaES) produces similar effects. The aim of this study was to determine the effects of different iaES frequencies on the parasympathetic and sympathetic divisions in different states of ANS imbalance.MethodsWe measured heart rate variability (HRV) and heart rate (HR) of non-modeled (normal) rats with the treatment of various frequencies to determine the optimal iaES frequency. The optimized iaES frequency was then applied to ANS imbalance model rats to elucidate its effects.Results30 Hz and 100 Hz iaES clearly affected HRV and HR in normal rats. 30 Hz iaES increased HRV, and decreased HR. 100 Hz iaES decreased HRV, and increased HR. In sympathetic excited state rats, 30 Hz iaES increased HRV. 100 Hz iaES increased HRV, and decreased HR. In parasympathetic excited state rats, 30 Hz and 100 Hz iaES decreased HRV. In sympathetic inhibited state rats, 30 Hz iaES decreased HRV, while 100 Hz iaES decreased HR. In parasympathetic inhibited rats, 30 Hz iaES decreased HR and 100 Hz iaES increased HRV.Conclusion30 Hz and 100 Hz iaES contribute to ANS rebalance by increasing vagal and sympathetic activity with different amplifications. The 30 Hz iaES exhibited positive effects in all the imbalanced states. 100 Hz iaES suppressed the sympathetic arm in sympathetic excitation and sympathetic/parasympathetic inhibition and suppressed the vagal arm and promoted the sympathetic arm in parasympathetic excitation and normal states