Unified Analysis of Internal Flowfield in an Integrated Rocket Ramjet Engine. I: Transition from Rocket Booster to Ramjet Sustainer

Abstract: A comprehensive numerical analysis was conducted to study the internal flow development in an integrated rocket-ramjet (IRR) propulsion system. The study consists of two parts: transition from the rocket booster to the ramjet sustainer and combustion dynamics during ramjet operation. The physical model of concern includes the entire IRR flow path, extending from the leading edge of the inlet center body through the exhaust nozzle. The theoretical formulation is based on the Farve-averaged conservation equations of mass, momentum, energy, and species concentration in axisymmetric coordinates and accommodates finite-rate chemical kinetics and variable thermophysical properties. Turbulence closure is achieved using a low-Reynolds-number k-ɛ two-equation model. The governing equations are solved numerically by means of a finite-volume preconditioned flux-differencing scheme capable of treating a chemically reacting flow over a wide range of Mach numbers. Various important physiochemical processes involved in the transition from the booster to the sustainer phase are investigated systemically. Emphasis is placed on the flow interactions between the inlet diffuser and combustor. The effects of operation timing on the flow evolution, fuel spread, ignition, and flame development are studied

Parallel Computing Application on Combustion and Emission Analysis of an Annular Gas Turbine Combustor

To analyze the emissions of a turbulent leanpremixed Methane-air combustor, a level set Gequation method has been implemented in the LargeEddy Simulation (LES) framework using parallelpersonal server. The server consists of 36 nodes with12 CPU cores a node. GRI-MECH 3.0 which is acompilation of 325 elementary chemical reactions with53 species, has been used with Presumed-ProbabilityDensity Function (PDF) method. The combustionflames from each injector move extremely dynamicallyand rotate in different directions from adjacentinjectors because the swirl directions of each injectorare opposite to the adjacent injectors. CO has highconcentration on the flame and disappears rapidlyafter the flame due to the lean premixed conditions. NOmole fraction increases continuously after the flameand then is emitted at the exit of combustor

Preparation of TiO2-Decorated Boron Particles by Wet Ball Milling and their Photoelectrochemical Hydrogen and Oxygen Evolution Reactions

TiO2-coated boron particles were prepared by a wet ball milling method, with the particle size distribution and average particle size being easily controlled by varying the milling operation time. Based on the results from X-ray photoelectron spectroscopy, transmission electron microscopy, energy dispersive X-ray analysis, and Fourier transform infrared spectroscopy, it was confirmed that the initial oxide layer on the boron particles surface was removed by the wet milling process, and that a new B–O–Ti bond was formed on the boron surface. The uniform TiO2 layer on the 150 nm boron particles was estimated to be 10 nm thick. Based on linear sweep voltammetry, cyclic voltammetry, current-time amperometry, and electrochemical impedance analyses, the potential for the application of TiO2-coated boron particles as a photoelectrochemical catalyst was demonstrated. A current of 250 μA was obtained at a potential of 0.5 V for hydrogen evolution, with an onset potential near to 0.0 V. Finally, a current of 220 μA was obtained at a potential of 1.0 V for oxygen evolution

Altered nucleocytoplasmic proteome and transcriptome distributions in an in vitro model of amyotrophic lateral sclerosis.

Aberrant nucleocytoplasmic localization of proteins has been implicated in many neurodegenerative diseases. Evidence suggests that cytoplasmic mislocalization of nuclear proteins such as transactive response DNA-binding protein 43 (TDP-43) and fused in sarcoma (FUS) may be associated with neurotoxicity in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. This study investigated the changes in nucleocytoplasmic distributions of the proteome and transcriptome in an in vitro model of ALS. After subcellular fractionation of motor neuron-like cell lines expressing wild-type or G93A mutant hSOD1, quantitative mass spectrometry and next-generation RNA sequencing (RNA-seq) were performed for the nuclear and cytoplasmic compartments. A subset of the results was validated via immunoblotting. A total of 1,925 proteins were identified in either the nuclear or cytoplasmic fractions, and 32% of these proteins were quantified in both fractions. The nucleocytoplasmic distribution of 37 proteins was significantly changed in mutant cells with nuclear and cytoplasmic shifts in 13 and 24 proteins, respectively (p<0.05). The proteins shifted towards the nucleus were enriched regarding pathways of RNA transport and processing (Dhx9, Fmr1, Srsf3, Srsf6, Tra2b), whereas protein folding (Cct5, Cct7, Cct8), aminoacyl-tRNA biosynthesis (Farsb, Nars, Txnrd1), synaptic vesicle cycle (Cltc, Nsf), Wnt signalling (Cltc, Plcb3, Plec, Psmd3, Ruvbl1) and Hippo signalling (Camk2d, Plcb3, Ruvbl1) pathways were over-represented in the proteins shifted to the cytoplasm. A weak correlation between the changes in protein and mRNA levels was found only in the nucleus, where mRNA was relatively abundant in mutant cells. This study provides a comprehensive dataset of the nucleocytoplasmic distribution of the proteome and transcriptome in an in vitro model of ALS. An integrated analysis of the nucleocytoplasmic distribution of the proteome and transcriptome demonstrated multiple candidate pathways including RNA processing/transport and protein synthesis and folding that may be relevant to the pathomechanism of ALS

Changes of 2-back task performance and physiological signals in ADHD children due to transient increase in oxygen level

This study investigated the effect of 92% oxygen administration on 2-back task performance, blood oxygen saturation (SpO(2) [%]), and heart rate (HR [bpm]) of Attention Deficit Hyperactivity Disorder (ADHD) children. Subjects were thirteen boys (mean 12.9 +/- 1.3 years) who were diagnosed as ADHD and are under treatment, having no disease or abnormality in a respiratory system or a periphery vascular flow system. The experiment consisted of two runs: one was a 2-back task under normal air (21% oxygen) condition and the other under hyperoxic air (92% oxygen) condition. The experiment sequence in each run consisted of three phases, which included the Adaptation phase (1 min) after oxygen administration, the Control phase (2 min) that maintained a stable condition before the task, and the Task phase (2 min) that performed 2-back task. SpO(2) and HR were measured during each phase. The analysis of cognitive performance with 92% oxygen administration when compared to 21% oxygen revealed that the response time decreased. When 92% oxygen in the air was supplied, the blood oxygen saturation increased while the heart rate decreased compared to those under the 21% oxygen condition. The response time also decreased for the subjects with a high SpO(2) during the Task phase. This showed that due to sufficient oxygen supply necessary for cognitive processing, SpO(2) increased and heart rate decreased. Therefore, an increase in cognitive ability such as a decrease in response time was observed in a transient period for ADHD children.close