2,573 research outputs found
A mutation in the interferon regulatory element of HBV may influence the response of interferon treatment in chronic hepatitis B patients
<p>Abstract</p> <p>Background</p> <p>A functional interferon regulatory element (IRE) has been found in the EnhI/X promoter region of hepatitis B virus (HBV) genome. The purpose of this study is to compare the gene order of responder and non-responder to interferon therapy in patients with chronic hepatitis B (CHB), so as to evaluate the relationship between IRE mutation and the response to interferon treatment for CHB patients.</p> <p>Results</p> <p>Synthetic therapeutic effect is divided into complete response (CR), partial response (PR) and non-response (NR). Among the 62 cases included in this study, 40 cases (64.5%) were in the response group (CR and PR) and 22 (35.5%) cases were in the NR group. Wild type sequence of HBV IRE TTTCACTTTC were found in 35 cases (56.5%), and five different IRE gene sequences. included TTTtACTTTC, TTTCAtTTTC, TTTtAtTTTC, TTTtACTTTt and cTTtACcTTC, were found in 22 cases (35.5%), 1 case (1.6%), 1 case (1.6%), 2 cases (3.2%) and 1 case (1.6%) respectively. There were 41.9%cases (26/62) with forth base C→T mutation, consisted of 32.5% (13/40) cases in response group and 59.1% (13/22) cases in NR group. Among the 35 cases with IRE sequences, there were 67.5% (27/40) cases in response group and 36.4% (8/22) in NR group, and the difference in IRE sequences between two groups was statistic significantly (P = 0.027). The result suggested that there is likely relationship between the forth base mutation (C→T) of IRE region and the response of HBV to Interferon therapy, and this mutation may partially decrease the inhibition effect of interferon on HBV.</p> <p>Conclusion</p> <p>The forth base C→T mutation in IRE element of HBV may partially influence the response of Interferon treatment in CHB patients.</p
The decay and the mixing
We study the and reactions, and pay attention to the different sources of isospin
violation and mixing of and resonances where these
resonances are dynamically generated from meson-meson interaction. We find that
the main reason of isospin violation is the isospin breaking in the meson-meson
transition matrices, and the other source is that the loops involving kaons
in the production mechanism provide a source of isospin violation because they
do not cancel by the different mass of the charged and neutral kaons. We obtain
a branching ratio for production of the order of .
Future experiments can address this problem and the production rate and shape
of the mass distribution will definitely help to better understand
the nature of scalar resonances.Comment: 12 pages, 4 figure
4-(4-Bromophenyl)-2,6-diphenylpyridine
In the title compound, C23H16BrN, the three benzene rings show a disrotatory counter-rotating arrangement around the central pyridine ring and are twisted with respect to the pyridine ring with dihedral angles of 19.56 (13), 27.54 (13) and 30.51 (13)°
Implementing universal nonadiabatic holonomic quantum gates with transmons
Geometric phases are well known to be noise-resilient in quantum
evolutions/operations. Holonomic quantum gates provide us with a robust way
towards universal quantum computation, as these quantum gates are actually
induced by nonabelian geometric phases. Here we propose and elaborate how to
efficiently implement universal nonadiabatic holonomic quantum gates on simpler
superconducting circuits, with a single transmon serving as a qubit. In our
proposal, an arbitrary single-qubit holonomic gate can be realized in a
single-loop scenario, by varying the amplitudes and phase difference of two
microwave fields resonantly coupled to a transmon, while nontrivial two-qubit
holonomic gates may be generated with a transmission-line resonator being
simultaneously coupled to the two target transmons in an effective resonant
way. Moreover, our scenario may readily be scaled up to a two-dimensional
lattice configuration, which is able to support large scalable quantum
computation, paving the way for practically implementing universal nonadiabatic
holonomic quantum computation with superconducting circuits.Comment: v3 Appendix added, v4 published version, v5 published version with
correction
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Modulating Linker Composition of Haptens Resulted in Improved Immunoassay for Histamine.
Histamine (HA) is an important food contaminant generated during food fermentation or spoilage. However, an immunoassay for direct (derivatization free) determination of HA has rarely been reported due to its small size to induce the desired antibodies by its current hapten-protein conjugates. In this work, despite violating the classical hapten design criteria which recommend introducing a linear aliphatic (phenyl free) linker into the immunizing hapten, a novel haptens, HA-245 designed and synthesized with a phenyl-contained linker, exhibited significantly enhanced immunological properties. Thus, a quality-improved monoclonal antibody (Mab) against HA was elicited by its hapten-carrier conjugates. Then, as the linear aliphatic linker contained haptens, Hapten B was used as linker-heterologous coating haptens to eliminate the recognition of linker antibodies. Indirect competitive ELISA (ic-ELISA) was developed with a 50% inhibition concentration (IC50) of 0.21 mg/L and a limit of detection (LOD) of 0.06 mg/L in buffer solution. The average recoveries of HA from spiked food samples for this ic-ELISA ranged from 84.1% and 108.5%, and the analysis results agreed well with those of referenced LC-MS/MS. This investigation not only realized derivatization-free immunoassay for HA, but also provided a valuable guidance for hapten design and development of immunoassay for small molecules
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