Revisiting Martin Luther King’s Last Campaign and Unfinished Agenda

“Stayed on freedom,” sung by slaves emancipating themselves during the U.S. Civil War and again in churches and during the civil rights movements of the 1950s and 1960s, reminds us that the struggle for African American freedom has been long and hard. “Solidarity Forever,” composed in 1915 by Industrial Workers of the World activist Ralph Chaplin during World War I, picks up another thread of American history: the struggle for worker rights. Chaplin’s song tells us of the exploitation of labor for the benefit of the wealthy, and that through organizing, workers can make their demands: “the union makes us strong.” These two songs are not usually sung together, but I like to sing them that way because they link the ongoing struggle in American history for freedom and for economic justice.1 As we rethink the historical legacy of Martin Luther King, Jr., who died in Memphis, Tennessee, from an assassin’s bullet on April 4, 1968, over fifty years ago, these two struggles remain interconnected

New validated rp-hplc method for simultaneous estimation of lamivudine and tenofovir disproxil fumarate in tablets

A simple, specific and precise reverse phase high performance liquid chromatographic method was developed and validated for simultaneous estimation of Lamivudine and Tenofovir disproxil fumarate in tablets. Quantification was achieved by using a reverse-phase C18 column (Inertsil ODS 3V, 250 mm x 4.6 mm; 5) at 31 o C. The mobile phase consisted of a mixture of phosphate buffer and acetonitrile in the ratio of 55:45 v/v at a flow rate of 1.2 mL/min. The retention times of Lamivudine and Tenofovir disproxil fumarate were found to be 2.430 min and 4.550 min respectively. The developed method was validated as per ICH Guidelines for linearity, accuracy, precision, detection limit, quantification limit, ruggedness, robustness, specificity and system suitability. The percentage recoveries for both of the drugs from their tablets were found to be 98.48 % and 98.64 % respectively. The method may successfully be employed for the simultaneous determination of Lamivudine and Tenofovir disproxil fumarate in pharmaceutical tablet dosage forms

Holographic Data Storage Technology- The future of Data Storage

In the present times technological advancement has grown at rapid rate. Today most of the people are using smart devices which comprises of various kinds of technologies. One of the most important factor in using technology is to store digital data. Presently most of the work are done using digital devices such as computers and mobiles and people need to store their data in devices but the device has limited amount of storage. So need arises to store more amount of data using less space. For this purpose we need to invent storage technologies which helps people to store more amount of data. In order to meet demands of greater storage there are various storage technologies such as different types of ROM, optical storage discs, USB flash drives which uses different technologies to store data. This paper focuses on Holographic data storage technology which helps people to store large amount of data

Revisiting Martin Luther King’s Last Campaign and Unfinished Agenda

“Stayed on freedom,” sung by slaves emancipating themselves during the U.S. Civil War and again in churches and during the civil rights movements of the 1950s and 1960s, reminds us that the struggle for African American freedom has been long and hard. “Solidarity Forever,” composed in 1915 by Industrial Workers of the World activist Ralph Chaplin during World War I, picks up another thread of American history: the struggle for worker rights. Chaplin’s song tells us of the exploitation of labor for the benefit of the wealthy, and that through organizing, workers can make their demands: “the union makes us strong.” These two songs are not usually sung together, but I like to sing them that way because they link the ongoing struggle in American history for freedom and for economic justice.1 As we rethink the historical legacy of Martin Luther King, Jr., who died in Memphis, Tennessee, from an assassin’s bullet on April 4, 1968, over fifty years ago, these two struggles remain interconnected

Alveolar rhabdomyosarcoma in children with histomorphological review

Rhabdomyosarcomas (RMS) are aggressive malignant neoplasm of mesenchymal origin, related to skeletal muscle lineage. These are the most common soft tissue tumors in children. The diagnosis is made by microscopic analysis and ancillary techniques like immunohistochemistry, electron microscopy, cytogenetics and molecular biology. We encountered a case of a 03 years old child who presented with a tender, reddish, soft swelling over cheek for three weeks. The FNAC was reported as a small round cell tumor, Probably Primitive Neuroectodermal Tumor (PNET). The biopsy of tumor revealed a small round cell tumor with an alveolar pattern. Tumor giant cells were absent and mitotic figures were infrequent. Hence, differentials of alveolar rhabdomyosarcoma and PNET were rendered. Immunohistochemistry (IHC) demonstrated desmin positivity. Thus, a final diagnosis of alveolar rhabdomyosarcoma was offered

Functionalized Carbon Nanotube and MnO2 Nanoflower Hybrid as an Electrode Material for Supercapacitor Application

Functionalized carbon nanotube (FCNT) and Manganese Oxide (MnO2) nanoflower hybrid material was synthesized using hydrothermal technique as a promising electrode material for supercapacitor applications. The morphological investigation revealed the formation of ‘nanoflower’ like structure of MnO2 connected with FCNT, thus paving an easy path for the conduction of electrons during the electrochemical mechanism. A significant improvement in capacitance properties was observed in the hybrid material, in which carbon nanotube acts as a conducting cylindrical path, while the major role of MnO2 was to store the charge, acting as an electrolyte reservoir leading to an overall improved electrochemical performance. The full cell electrochemical analysis of FCNT-MnO2 hybrid using 3 M potassium hydroxide (KOH) electrolyte indicated a specific capacitance of 359.53 F g−1, specific energy of 49.93 Wh kg−1 and maximum specific power of 898.84 W kg−1 at 5 mV s−1. The results show promise for the future of supercapacitor development based on hybrid electrode materials, where high specific energy can be achieved along with high specific power and long cycle life

The Role of the PAX8/PPARγ Fusion Oncogene in Thyroid Cancer

Thyroid cancer is uncommon and exhibits relatively low mortality rates. However, a subset of patients experience inexorable growth, metastatic spread, and mortality. Unfortunately, for these patients, there have been few significant advances in treatment during the last 50 years. While substantial advances have been made in recent years about the molecular genetic events underlying papillary thyroid cancer, the more aggressive follicular thyroid cancer remains poorly understood. The recent discovery of the PAX8/PPARγ translocation in follicular thyroid carcinoma has promoted progress in the role of PPARγ as a tumor suppressor and potential therapeutic target. The PAX8/PPARγ fusion gene appears to be an oncogene. It is most often expressed in follicular carcinomas and exerts a dominant-negative effect on wild-type PPARγ, and stimulates transcription of PAX8-responsive promoters. PPARγ agonists have shown promising results in vitro, although very few studies have been conducted to assess the clinical impact of these agents