Condensation of Nonazeotropic Refrigerant Mixture R114/R113 in Horizontal Annuli with an Enhanced Inner Tube : Experimental Results

Local heat transfer and pressure drop measurements were made during condensation of a nonazeotropic refrigerant mixture R114/R113 in the annuli of horizontal double-tube condensers. The inner tube was a 19.1mm o.d. corrugated copper tube with soldered wire fins on the outer surface. The outer tubes were smooth tubes with inside diameter D_i of 29.9 and 25.0mm. The pressure drop and the heat transfer coefficient based on the bulk vapor-to-wall temperature difference were considerably smaller for R114/R113 than for R113. The vapor phase mass transfer coefficient β_n was higher for larger test fluid mass velocity G and D_i. At constant values of G and D_i, β_n was higher for larger condensation mass flux. The radial distribution of the vapor temperature was affected by the vapor velocity, becoming flatter at the outer part of the annulus and steeper near the liquid-vapor interface as the vapor velocity increased.蒸気圧縮式ヒートポンプ、冷凍機などの成績係数を向上させるための一方策としてローレンツサイクルが提案され、このサイクルに近づけることのできる非共沸2成分混合冷媒が実用されつつある。しかし、この冷媒が凝縮する際には低沸点蒸気が不凝縮ガスと類似の挙動を示すため、凝縮伝熱性能が単成分蒸気に比べて低下する。したがって、この冷媒を用いる凝縮器の性能向上を図るためには、凝縮液膜の熱抵抗と混合気の拡散抵抗の両者を減少させる必要がある。著者らは前提で純冷媒用の伝熱促進管の一種であるワイヤフィン付きコルゲート管を内管とする水平二重管環状部における非共沸混合冷媒R114/R113の凝縮実験を行い、圧力降下の摩擦成分は純冷媒に対する実験式で整理できること、凝縮側の熱抵抗にしめる気相の熱抵抗の割合は冷媒流量の増大につれて減少することを示した。そして、混合気相の物質伝達係数を円管上の強制対流凝縮理論から導かれた無次元パラメータを用いて整理した。しかし、より一般性のある整理式を得るためにはフィン形状、内外管径比などの影響を明らかにする必要がある。なお、フロン系非共沸2成分混合冷媒の管内、シェル側あるいは環状部における凝縮については最近多くの実験的研究が報告されているが、混合気相の物質伝達について検討したものは少なく、実験データの蓄積が望まれる。本報では、前報の内管とフィン配列が多少異なる管を内管とし、内径の異なる2種類の平滑管を外管とする水平二重管環状部におけるR114/R113の凝縮実験を行い、前報の結果と比較する。また、混合気相の温度分布測定結果についても述べる

Experimental Study of Condensation Heat Transfer from Downward-Facing Inclined Surfaces

Experiments were perfomed to study the effect of surface inclination on condensation heat transfer from downward-facing horizontal surfaces. A smooth surface and two low-finned surfaces with a length of 50mm were tested for condensation of R-113. The angle of inclination from the horizontal φ ranged from 0 to 90 deg. For the smooth surface, the heat tranfer coefficient α first decreased with the increasing of φ, then took a minimum near 5 deg, and then increased monotonically with further increasing φ. For the low-finned surfaces, α increased sharply with φ in the range of 0 to 30 deg, and then increased moderately with further increasing φ. The heat tranpfer coefficient for the better performing finned surface was 2.5, 9 and 12 times the smooth surface value for φ=0, 10 and 90 deg., respectively.電子素子の発熱密度の増大にともない、高性能の冷却法として浸漬冷却に対する関心が高まり、研究が盛んになっている。この冷却法では、発生蒸気を凝縮させるための凝縮器が必要となる。その形式として種々のものが検討されているが、容器の上面または側面を凝縮器として使用するものが最も簡便な方式であると考えられる。著者らはさきに下向き水平凝縮面下部に蒸気空間が存在する場合および凝縮面が液中に浸漬されている場合の熱伝達特性とその促進法について実験的に検討し、多孔質排液板を取付けたフィン付き面を使用することによって熱伝達が平滑面に比べて大幅に促進されることを見いだした。これは、フィン間溝部に充満した凝縮液が毛細管力によって効率良く多孔質排液板へ引き込まれ、フィン頂部が高性能の凝縮面として働くためである。同様の排液効果は伝熱面を傾斜させ、重力を利用することによっても期待できる。本報では平滑面と2種類のローフィン付き面をとりあげ、下向き面上の凝縮熱伝達に及ぼす伝熱面傾斜角の影響を冷媒R113を用いて実験的に検討する

Condensation of Nonazeotropic Refrigerant Mixture R114/R113 in Horizontal Annuli with an Enhanced Inner Tube : Correlation of Frictional Pressure Drop and Vapor Phase Mass Transfer

Frictional pressure gradient and vapor phase mass transfer correlations were developed for condensation of nonazeotropic refrigerant mixture R114/R113 in the annuli of horizontal double tubes with an enhanced inner tube. The frictional pressure gradient data were correlated fairly well by a previously developed empirical equation for condensation of pure refrigerants. The vapor phase mass transfer correlation was based on the previous results for turbulent flow in smooth and rough tubes with and without surface suction. For given conditions of vapor and tube wall, the heat transfer coefficient can be calculated by using the correlations for the vapor phase mass transfer coefficient and the heat transfer coefficient for the condensate film. The calculated values agree with the measured data to a mean absolute deviation of 14.3%.蒸気圧縮式ヒートポンプ、冷凍機の成績係数向上させることのできる作動媒体として、非共沸2成分混合冷媒が有望視されており、最近その凝縮熱伝達に関する研究が開発に行われている。非共沸2成分混合冷媒が凝縮する際には、低沸点蒸気が不凝縮ガスと類似な挙動を示すため、熱伝達係数が単成分蒸気に比べて低下する。したがって、この冷媒を用いる凝縮器については液膜の伝熱促進とともに混合気の物質伝達促進をはかる必要がある。著者らは伝熱促進管の一種であるワイヤフィン付きコルゲート管を内管とする水平二重管の環状部における冷媒R11およびR113ならびに非共沸混合冷媒R114/R113の凝縮な関する一連の実験を行い、圧力降下と熱伝達の特性を明らかにした。R114/R113に関する第1報では液膜の伝熱特性がR113の場合と同一であると仮定して、混合気相の物質伝達係数を求め、円管上の強制対流凝縮理論から導かれた無次元パラメータを用いてデータ整理を行った。また、圧力降下の摩擦成分は純冷媒に対する実験式によって良好に整理できることを示した。第2報では、第1報の内管とフィン配列が多少異なる内管を使用し、外管内径を2種類に変化させて混合気相の物質伝達特性をより詳細に調べた。その結果、第1報で得られた物質伝達の式は凝縮質量流束の影響をよく表現するが、質量速度の影響および予測精度に関しては十分でないことが明らかになった。本報では、管内の乱流熱・物質伝達に関する従来の実験および理論解析の結果をもとにして、より一般性のある物質伝達の整理式を導く。また、圧力降下の摩擦成分の整理法についても検討する。なお、記号表中には本報で用いる主な記号のみ列挙する。その他の記号は第2報と同一である

IL-1β Suppresses the Formation of Osteoclasts by Increasing OPG Production via an Autocrine Mechanism Involving Celecoxib-Related Prostaglandins in Chondrocytes

Elevated interleukin (IL)-1 concentrations in synovial fluid have been implicated in joint bone and cartilage destruction. Previously, we showed that IL-1β stimulated the expression of prostaglandin (PG) receptor EP4 via increased PGE2 production. However, the effect of IL-1β on osteoclast formation via chondrocytes is unclear. Therefore, we examined the effect of IL-1β and/or celecoxib on the expression of macrophage colony-stimulating factor (M-CSF), receptor activator of NF-κB ligand (RANKL), and osteoprotegerin (OPG) in human chondrocytes, and the indirect effect of IL-1β on osteoclast-like cell formation using RAW264.7 cells. OPG and RANKL expression increased with IL-1β; whereas M-CSF expression decreased. Celecoxib blocked the stimulatory effect of IL-1β. Conditioned medium from IL-1β-treated chondrocytes decreased TRAP staining in RAW264.7 cells. These results suggest that IL-1β suppresses the formation of osteoclast-like cells via increased OPG production and decreased M-CSF production in chondrocytes, and OPG production may increase through an autocrine mechanism involving celecoxib-related PGs

Possible utilization of salivary IFN-γ/IL-4 ratio as a marker of chronic stress in healthy individuals

Introduction: Several studies show that psychological stress reduces Th1/Th2 ratio in blood samples. However, evidence is scarce regarding the cytokine alterations during stress in saliva. We investigated the influence of chronic stress on Th1/Th2 ratio and cytokine profiles in the saliva of healthy individuals. Further, we examined the associations of the salivary cytokine levels with sleep and attention problems, which are closely related with psychological stress. / Methods: Salivary levels of 27 cytokines were measured by multiplex bead array assays in 31 healthy young individuals (health science students and hospital staff consisting of 11 men and 20 women, mean age [standard deviation] =21.5 [0.8] years). The Kessler Psychological Distress scale (K10) and Athens Insomnia Scale (AIS) were administered to assess subjective chronic psychological stress and sleep problems. Further, participants were asked to wear Actigraph GT3X accelerometers for 3 days to assess the total sleep time. Attention problems were assessed by administering the Integrated Visual and Auditory Continuous Performance Test (IVA-CPT). / Results: Thirteen cytokines with >80% detectable results were included in the main analyses. The IFN-gamma/IL-4 ratio, which is a commonly used index for Th1/Th2 ratio, showed significant negative correlations with the K10 and AIS scores. None of the cytokines were significantly associated with sex, body mass index, sleep index measured by Actigraph, or IVA-CPT scores. / Conclusion: Chronic stress may be associated with alterations of the Th1/Th2 balance in salivary cytokine production. IFN-gamma/IL-4 ratio in saliva may serve as a potential biomarker of chronic stress in healthy individuals.ArticleNeuropsychopharmacology reports 41(1) : 65-72(2021)journal articl

Is Preoperative Magnetic Resonance Imaging in a Daily Clinical Setting Useful to Evaluate Tumor Invasion Beyond the Pseudocapsule in Renal Cell Carcinoma?

Background: We wanted to clarify whether preoperative magnetic resonance imaging (MRI) in the clinical setting can evaluate the pathologic pseudocapsule (PC) morphology with high accuracy in renal cell carcinoma (RCC). Methods: We retrospectively analyzed 34 consecutive patients who underwent MRI (1.5 or 3.0T, 5 mm slices) prior to partial nephrectomy (PN) for RCC at our institution between January 2010 and December 2019. First, the correlation between PC morphology (complete or incomplete) and tumor infiltration to the renal parenchyma was examined as pathologic validation. Second, the concordance rate of PC morphology between pathologic tissue and preoperative MRI was evaluated as radiologic validation. Third, risk factor for renal parenchymal invasion in RCC was analyzed. Results: In the pathologic validation, parenchymal invasion rates were 11% and 28% in the “complete PC” and “incomplete PC” groups, respectively. In the radiologic validation, pathological PC morphology could be diagnosed on preoperative MRI in 17 patients (50.0%). “None PC” on MRI had the lowest positive predictive value (PPV) (0%), “partial PC” on MRI had a good PPV (76.5%), “complete PC” on MRI had a relatively low PPV (33.3%). Unfortunately, these data were insufficient for diagnostic accuracy. As risk factor for renal parenchymal invasion in RCC, only pathologic subtype (non-clear cell) was found to have significant differences in the multivariate analysis. Conclusion: The results of this study suggest that renal tumors with pathologically incomplete PC have a high possibility of renal parenchymal invasion. However, it is currently difficult to accurately evaluate pathologic PC morphology by preoperative MRI in the clinical setting

Negative Correlation between Serum Cytokine Levels and Cognitive Abilities in Children with Autism Spectrum Disorder

Evidence suggests that cytokines may be one of the major factors influencing cognitive development in those with autism spectrum disorder (ASD). To shed light on the neural and cognitive mechanisms of ASD, we investigated the association between peripheral cytokine levels and cognitive profiles in children with ASD. The serum levels of 10 cytokines (granulocyte macrophage colony-stimulating factor, interferon (IFN)-γ, interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, and tumor necrosis factor-α) were examined in 14 children with ASD using the Human Ultrasensitive Cytokine Magnetic 10-Plex Panel for the Luminex platform. The Wechsler Intelligence Scale for Children (WISC) was administered to each subject, and the relationships between WISC scores and serum levels of the cytokines were examined. The full-scale intelligence quotient (IQ) was significantly negatively correlated with the levels of IL-6 (Spearman’s rank, p < 0.0001, false discovery rate q < 0.01). The levels of IL-6 and IFN-γ showed significant negative correlations with the verbal comprehension index (p < 0.001, q < 0.01) and working memory index (p < 0.01, q < 0.05), respectively. No other cytokines were significantly correlated with full-scale IQ or with any of the subscale scores of the WISC. The present results suggest negative correlations of IL-6 and IFN-γ levels with cognitive development of children with ASD. Our preliminary findings add to the evidence that cytokines may play a role in the neural development in ASD.ArticleJOURNAL OF INTELLIGENCE. 5(2):19 (2017)journal articl