A Flight Evaluation of a VTOL Jet Transport Under Visual and Simulated Instrument Conditions

Transition, approach, and vertical landing tests for VTOL transport in terminal are

Wind-tunnel and Flight Investigations of the Use of Leading-Edge Area Suction for the Purpose of Increasing the Maximum Lift Coefficient of a 35 Degree Swept-Wing Airplane

An investigation was undertaken to determine the increase in maximum lift coefficient that could be obtained by applying area suction near the leading edge of a wing. This investigation was performed first with a 35 degree swept-wing model in the wind tunnel, and then with an operational 35 degree swept-wing airplane which was modified in accord with the wind-tunnel results. The wind-tunnel and flight tests indicated that the maximum lift coefficient was increased more than 50 percent by the use of area suction. Good agreement was obtained in the comparison of the wind-tunnel results with those measured in flight

Discovery and Characterization of Protein-Modifying Natural Products by MALDI Mass Spectrometry Reveal Potent SIRT1 and p300 Inhibitors

A straightforward MALDI MS method facilitates the unbiased screening and characterization of compounds that modify protein activity. This procedure can be used to circumvent analytical problems deriving from compounds with autofluorescence. Various posttranslationally active enzymes like deacetylases, acetyltransferases, kinases, phosphatases, and methyltransferases can be studied in the presented way

Genetic basis and detection of unintended effects in genetically modified crop plants

In January 2014, an international meeting sponsored by the International Life Sciences Institute/Health and Environmental Sciences Institute and the Canadian Food Inspection Agency titled “Genetic Basis of Unintended Effects in Modified Plants” was held in Ottawa, Canada, bringing together over 75 scientists from academia, government, and the agro-biotech industry. The objectives of the meeting were to explore current knowledge and identify areas requiring further study on unintended effects in plants and to discuss how this information can inform and improve genetically modified (GM) crop risk assessments. The meeting featured presentations on the molecular basis of plant genome variability in general, unintended changes at the molecular and phenotypic levels, and the development and use of hypothesis-driven evaluations of unintended effects in assessing conventional and GM crops. The development and role of emerging “omics” technologies in the assessment of unintended effects was also discussed. Several themes recurred in a number of talks; for example, a common observation was that no system for genetic modification, including conventional methods of plant breeding, is without unintended effects. Another common observation was that “unintended” does not necessarily mean “harmful”. This paper summarizes key points from the information presented at the meeting to provide readers with current viewpoints on these topics

NACA Technical Reports

"An investigation was undertaken to determine the increase in maximum lift coefficient that could be obtained by applying area suction near the leading edge of a wing. This investigation was performed first with a 35 degree swept-wing model in the wind tunnel, and then with an operational 35 degree swept-wing airplane which was modified in accord with the wind-tunnel results. The wind-tunnel and flight tests indicated that the maximum lift coefficient was increased more than 50 percent by the use of area suction. Good agreement was obtained in the comparison of the wind-tunnel results with those measured in flight" (p. 1)

Soybean (Glycine max) allergy in Europe: Gly m 5 (beta-conglycinin) and Gly m 6 (glycinin) are potential diagnostic markers for severe allergic reactions to soy

BACKGROUND: Soybean is considered an important allergenic food, but published data on soybean allergens are controversial. OBJECTIVE: We sought to identify relevant soybean allergens and correlate the IgE-binding pattern to clinical characteristics in European patients with confirmed soy allergy. METHODS: IgE-reactive proteins were identified from a soybean cDNA expression library, purified from natural soybean source, or expressed in Escherichia coli. The IgE reactivity in 30 sera from subjects with a positive double-blind, placebo-controlled soybean challenge (n = 25) or a convincing history of anaphylaxis to soy (n = 5) was analyzed by ELISA or CAP-FEIA. RESULTS: All subunits of Gly m 5 (beta-conglycinin) and Gly m 6 (glycinin) were IgE-reactive: 53% (16/30) of the study subjects had specific IgE to at least 1 major storage protein, 43% (13/30) to Gly m 5 , and 36% (11/30) to Gly m 6. Gly m 5 was IgE-reactive in 5 of 5 and Gly m 6 in 3 of 5 children. IgE-binding to Gly m 5 or Gly m 6 was found in 86% (6/7) subjects with anaphylaxis to soy and in 55% (6/11) of subjects with moderate but only 33% (4/12) of subjects with mild soy-related symptoms. The odds ratio (P < .05) for severe versus mild allergic reactions in subjects with specific IgE to Gly m 5 or Gly m6 was 12/1. CONCLUSION: Sensitization to the soybean allergens Gly m 5 or Gly m 6 is potentially indicative for severe allergic reactions to soy