Andrea Holt in a Senior Soprano Recital

This is the program for the senior soprano recital of Andrea Holt. Ms. Holt was accompanied on the piano by Steven Cole and Barry McVinney on the flute. This recital took place on March 10, 1994, in the McBeth Recital Hall in the Mabee Fine Arts Center

Creating and Conducting Intergenerational Learning in Higher Education

The creation, conduction and revision of a one of a kind intergenerational course taught in the Grand Valley State University Fredrick Meijer Honors College. Elders and Traditional Honors College Freshman came together in a mixed classroom in order to bridge the gaps of communication and misunderstanding between generations

Contesting the Mainstream:Understanding Alternative News Media and Its Contribution to Diversity

In this introduction to the special issue Contesting the Mainstream: Understanding Alternative News Media, we discuss how and to what extent alternative news media contribute to news diversity. We elaborate on the concept of diversity, the democratic role of media, and the normative implications of alternative media in the wider media sphere. Based on the articles published in this special issue, that offer new and revealing empirical insights into a wide range of alternative media sites and their practices, from Europe, Asia, the Middle East, North America, and Latin America, we argue that it becomes increasingly clear that awareness about normative positions within alternative media research is imperative. This is because an appreciation of the normative purpose of alternative media guides our ability to understand their role in society. The necessity for thinking through such positions is particularly exemplified by the most radical alternative media actors, and how they are debated and studied in different political systems

Symposium on Criminal Justice Reform and Social Justice

This Symposium will present experts and Policy Makers in the Fields of Law Policing and Public Policy in a scholarly environment to discuss important issues of Criminal and Social Justice. Hosted by Governors State University Departments of: Criminal Justice, Public Administration, Political Science and the Institute of Politics, Public Policy and Social Justice (IPPSJ

The Irrigation Efficiency Trap: Rational Farm-Scale Decisions Can Lead to Poor Hydrologic Outcomes at the Basin Scale

Agricultural irrigation practices have changed through time as technology has enabled more efficient conveyance and application. In some agricultural regions, irrigation can contribute to incidental aquifer recharge important for groundwater return flows to streams. The Henrys Fork Snake River, Idaho (United States) overlies a portion of the Eastern Snake Plain Aquifer, where irrigated agriculture has occurred for over a century. Using irrigator interviews, aerial and satellite imagery, and statistical streamflow analysis, we document the impact of farm-scale decisions on basin-scale hydrology. Motivated to improve economic efficiency, irrigators began converting from surface to center-pivot sprinkler irrigation in the 1950s, with rapid adoption of center-pivot sprinklers through 2000. Between 1978–2000 and 2001–2022, annual surface-water diversion decreased by 311 Mm3 (23%) and annual return flow to the river decreased by 299 Mm3 over the same period. Some reaches that gained water during 1978–2000 lost water to the aquifer during the later period. We use an interdisciplinary approach to demonstrate how individual farm-scale improvements in irrigation efficiency can cumulatively affect hydrology at the landscape scale and alter groundwater-surface water relationships. Return flows are an important part of basin hydrology in irrigated landscapes and we discuss how managed and incidental aquifer recharge can be implemented to recover return flows to rivers

Non-Coding-Regulatory Regions Of Human Brain Genes Delineated By Bacterial Artificial Chromosome Knock-In Mice

Background The next big challenge in human genetics is understanding the 98% of the genome that comprises non-coding DNA. Hidden in this DNA are sequences critical for gene regulation, and new experimental strategies are needed to understand the functional role of gene-regulation sequences in health and disease. In this study, we build upon our HuGX (\u27high-throughput human genes on the X chromosome’) strategy to expand our understanding of human gene regulation in vivo. Results In all, ten human genes known to express in therapeutically important brain regions were chosen for study. For eight of these genes, human bacterial artificial chromosome clones were identified, retrofitted with a reporter, knocked single-copy into the Hprt locus in mouse embryonic stem cells, and mouse strains derived. Five of these human genes expressed in mouse, and all expressed in the adult brain region for which they were chosen. This defined the boundaries of the genomic DNA sufficient for brain expression, and refined our knowledge regarding the complexity of gene regulation. We also characterized for the first time the expression of human MAOA and NR2F2, two genes for which the mouse homologs have been extensively studied in the central nervous system (CNS), and AMOTL1 and NOV, for which roles in CNS have been unclear. Conclusions We have demonstrated the use of the HuGX strategy to functionally delineate non-coding-regulatory regions of therapeutically important human brain genes. Our results also show that a careful investigation, using publicly available resources and bioinformatics, can lead to accurate predictions of gene expression

NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth

Mitochondria are emerging as important players in the transformation process of cells, maintaining the biosynthetic and energetic capacities of cancer cells and serving as one of the primary sites of apoptosis and autophagy regulation. Although several avenues of cancer therapy have focused on mitochondria, progress in developing mitochondria-targeting anticancer drugs nonetheless has been slow, owing to the limited number of known mitochondrial target proteins that link metabolism with autophagy or cell death. Recent studies have demonstrated that two members of the newly discovered family of NEET proteins, NAF-1 (CISD2) and mitoNEET (mNT; CISD1), could play such a role in cancer cells. NAF-1 was shown to be a key player in regulating autophagy, and mNT was proposed to mediate iron and reactive oxygen homeostasis in mitochondria. Here we show that the protein levels of NAF-1 and mNT are elevated in human epithelial breast cancer cells, and that suppressing the level of these proteins using shRNA results in significantly reduced cell proliferation and tumor growth, decreased mitochondrial performance, uncontrolled accumulation of iron and reactive oxygen in mitochondria, and activation of autophagy. Our findings highlight NEET proteins as promising mitochondrial targets for cancer therapy