Effects of Pediococcus parvulus 2.6 and its exopolysaccharide on plasma cholesterol levels and inflammatory markers in mice

Intake of dietary fibres may reduce the prevalence of physiological risk factors of the metabolic syndrome, such as high plasma lipid levels and low-grade inflammatory state. Dietary fibres are usually of plant origin however microbial exopolysaccharides (EPSs) have analogue structures that could potentially exert similar physiological effects. Pediococcus parvulus 2.6 (Pd 2.6) excretes a ropy EPS and has previously shown probiotic potential. The aim of this work was to evaluate physiological effects of Pd 2.6 and its EPS in vivo. The live Pd 2.6 (both the ropy and non-ropy isogenic variant) and its purified EPS were fed to hypercholesterolemic LDL-receptor deficient mice for 6 weeks to investigate their effects on cholesterol levels and the inflammatory tone of the animals. Both variants of Pd 2.6 survived passage through the mouse gut fulfilling an important criterion of probiotics. The ability to produce EPS was conferring an advantage to survival (faecal recovery of 3.7 (1.9-8.7) vs. 0.21 (0.14-0.34) *108 CFU, P < 0.001, median and 25th and 75th percentiles). The ropy Pd 2.6 decreased the levels of soluble vascular cell adhesion molecule-1 compared to the EPS alone (591 ± 14 vs. 646 ± 13 ng/ml, P < 0.05). An increase in liver weight in mice fed the purified EPS was observed, but with no change in liver lipids. No changes in blood lipids were detected in any group. Further the EPS induced growth of the caecal tissue and increased the amount of caecal content showing bulking properties like that of a dietary fibre

The Evolution of Click-n-Mortar E-tailing in Denmark

The paper at hand presents an extension and application of Kotzab & Madlbergers (Kotzab & Madlberger, 2001) original clicks-and-mortar web-scan framework, which is here used to reexamine the click-and-mortar activities of the top 100 Danish retailers and compare with results from the identical study last year. The first part of the paper describes the development and rationale behind the model used, the second part describes the results obtained and describes the evolution by analysing data from 2001, 2002 and 2003. The empirical results show a shift toward selling in the internet channel, and a differentiation between the most sophisticated sites: they focus on either Marketing or Logistics processes

The Effect of Dietary Fish Oil in addition to Lifestyle Counselling on Lipid Oxidation and Body Composition in Slightly Overweight Teenage Boys

Objective. n-3 long-chain polyunsaturated fatty acids (LCPUFAs) have shown potential to increase lipid oxidation and prevent obesity. Subjects. Seventy-eight boys aged 13–15 y with whole-body fat% of 30 ± 9% were randomly assigned to consume bread with fish oil (FO) (1.5 g n-3 LCPUFA/d) or vegetable oil for 16 weeks. All boys were counselled to improve diet and exercise habits. Results. Lifestyle counselling resulted in decreased sugar intake but did not change the physical activity level. Whole-body fat% decreased 0.7 ± 2.5% and 0.6 ± 2.2%, resting metabolic rate after the intervention was 7150 ± 1134 kJ/d versus 7150 ± 1042 kJ/d, and the respiratory quotient was 0.89 ± 0.05 versus 0.88 ± 0.05, in the FO and control group, respectively. No group differences were significant. Conclusion. FO-supplementation to slightly overweight teenage boys did not result in beneficial effects on RMR, lipid oxidation, or body composition

Global MHD simulations of Mercury's magnetosphere with coupled planetary interior: Induction effect of the planetary conducting core on the global interaction

Mercury's comparatively weak intrinsic magnetic field and its close proximity to the Sun lead to a magnetosphere that undergoes more direct space‐weathering interactions than other planets. A unique aspect of Mercury's interaction system arises from the large ratio of the scale of the planet to the scale of the magnetosphere and the presence of a large‐size core composed of highly conducting material. Consequently, there is strong feedback between the planetary interior and the magnetosphere, especially under conditions of strong external forcing. Understanding the coupled solar wind‐magnetosphere‐interior interaction at Mercury requires not only analysis of observations but also a modeling framework that is both comprehensive and inclusive. We have developed a new global MHD model for Mercury in which the planetary interior is modeled as layers of different electrical conductivities that electromagnetically couple to the surrounding plasma environment. This new modeling capability allows us to characterize the dynamical response of Mercury to time‐varying external conditions in a self‐consistent manner. Comparison of our model results with observations by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft shows that the model provides a reasonably good representation of the global magnetosphere. To demonstrate the capability to model induction effects, we have performed idealized simulations in which Mercury's magnetosphere is impacted by a solar wind pressure enhancement. Our results show that due to the induction effect, Mercury's core exerts strong global influences on the way Mercury responds to changes in the external environment, including modifying the global magnetospheric structure and affecting the extent to which the solar wind directly impacts the surface. The global MHD model presented here represents a crucial step toward establishing a modeling framework that enables self‐consistent characterization of Mercury's tightly coupled planetary interior‐magnetosphere system.Key PointsDeveloped global MHD model of Mercury's magnetosphere with coupled interiorThe global model is able to self‐consistently model induction effect at the coreInduction effect is shown to have significant effects on the global interactionPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/112187/1/jgra51879.pd

Efficiency and scalability in producing feed from manure using the common housefly

Key-note (Insects to feed the world): Efficiency and scalability in producing feed from manure using the common housefl

Using a Living Lab Methodology for Developing Energy Savings Solutions

It is becoming increasingly important to create a sustainable environment. One important step is to reduce the energy consumption. In Europe, 25% of the energy used is consumed by private households. How energy is produced and consumed in different European countries varies a lot, thus it is hard to develop general solutions based on country-specific traits. The aim of this paper is to describe an approach to cross-country development of an energy savings solution. This paper reports on the usage of a method based on collecting users needs related to their current energy consumption, the actions they can take, and the possible future solutions they want to see