131 research outputs found
Axions and their Relatives
A review of the status of axions and axion-like particles is given. Special
attention is devoted to the recent results of the PVLAS collaboration, which
are in conflict with the CAST data and with the astrophysical constraints.
Solutions to the puzzle and the implications for new physics are discussed. The
question of axion-like particles being dark matter is also addressed.Comment: Updated version of an invited talk at the Axion Training (CERN,
December 2005). To appear as a Lecture Notes in Physics (Springer-Verlag),
edited by B. Beltran, M. Kuster and G. Raffel
Conditions for Successful Extended Inflation
We investigate, in a model-independent way, the conditions required to obtain
a satisfactory model of extended inflation in which inflation is brought to an
end by a first-order phase transition. The constraints are that the correct
present strength of the gravitational coupling is obtained, that the present
theory of gravity is satisfactorily close to general relativity, that the
perturbation spectra from inflation are compatible with large scale structure
observations and that the bubble spectrum produced at the phase transition
doesn't conflict with the observed level of microwave background anisotropies.
We demonstrate that these constraints can be summarized in terms of the
behaviour in the conformally related Einstein frame, and can be compactly
illustrated graphically. We confirm the failure of existing models including
the original extended inflation model, and construct models, albeit rather
contrived ones, which satisfy all existing constraints.Comment: 8 pages RevTeX file with one figure incorporated (uses RevTeX and
epsf). Also available by e-mailing ARL, or by WWW at
http://star-www.maps.susx.ac.uk/papers/infcos_papers.html; Revised to include
extra references, results unchanged, to appear Phys Rev
The Centurion 18 telescope of the Wise Observatory
We describe the second telescope of the Wise Observatory, a 0.46-m Centurion
18 (C18) installed in 2005, which enhances significantly the observing
possibilities. The telescope operates from a small dome and is equipped with a
large-format CCD camera. In the last two years this telescope was intensively
used in a variety of monitoring projects.
The operation of the C18 is now automatic, requiring only start-up at the
beginning of a night and close-down at dawn. The observations are mostly
performed remotely from the Tel Aviv campus or even from the observer's home.
The entire facility was erected for a component cost of about 70k$ and a labor
investment of a total of one man-year.
We describe three types of projects undertaken with this new facility: the
measurement of asteroid light variability with the purpose of determining
physical parameters and binarity, the following-up of transiting extrasolar
planets, and the study of AGN variability. The successful implementation of the
C18 demonstrates the viability of small telescopes in an age of huge
light-collectors, provided the operation of such facilities is very efficient.Comment: 16 pages, 13 figures, some figures quality was degraded, accepted for
publication in Astrophysics and Space Scienc
Phenomenology of a Pseudo-Scalar Inflaton: Naturally Large Nongaussianity
Many controlled realizations of chaotic inflation employ pseudo-scalar
axions. Pseudo-scalars \phi are naturally coupled to gauge fields through c
\phi F \tilde{F}. In the presence of this coupling, gauge field quanta are
copiously produced by the rolling inflaton. The produced gauge quanta, in turn,
source inflaton fluctuations via inverse decay. These new cosmological
perturbations add incoherently with the "vacuum" perturbations, and are highly
nongaussian. This provides a natural mechanism to generate large nongaussianity
in single or multi field slow-roll inflation. The resulting phenomenological
signatures are highly distinctive: large nongaussianity of (nearly) equilateral
shape, in addition to detectably large values of both the scalar spectral tilt
and tensor-to-scalar ratio (both being typical of large field inflation). The
WMAP bound on nongaussianity implies that the coupling, c, of the pseudo-scalar
inflaton to any gauge field must be smaller than about 10^{2} M_p^{-1}.Comment: 45 pages, 7 figure
Against all odds? Forming the planet of the HD196885 binary
HD196885Ab is the most "extreme" planet-in-a-binary discovered to date, whose
orbit places it at the limit for orbital stability. The presence of a planet in
such a highly perturbed region poses a clear challenge to planet-formation
scenarios. We investigate this issue by focusing on the planet-formation stage
that is arguably the most sensitive to binary perturbations: the mutual
accretion of kilometre-sized planetesimals. To this effect we numerically
estimate the impact velocities amongst a population of circumprimary
planetesimals. We find that most of the circumprimary disc is strongly hostile
to planetesimal accretion, especially the region around 2.6AU (the planet's
location) where binary perturbations induce planetesimal-shattering of
more than 1km/s. Possible solutions to the paradox of having a planet in such
accretion-hostile regions are 1) that initial planetesimals were very big, at
least 250km, 2) that the binary had an initial orbit at least twice the present
one, and was later compacted due to early stellar encounters, 3) that
planetesimals did not grow by mutual impacts but by sweeping of dust (the
"snowball" growth mode identified by Xie et al., 2010b), or 4) that HD196885Ab
was formed not by core-accretion but by the concurent disc instability
mechanism. All of these 4 scenarios remain however highly conjectural.Comment: accepted for publication by Celestial Mechanics and Dynamical
Astronomy (Special issue on EXOPLANETS
Primordial fluctuations and non-Gaussianities from multifield DBI Galileon inflation
We study a cosmological scenario in which the DBI action governing the motion
of a D3-brane in a higher-dimensional spacetime is supplemented with an induced
gravity term. The latter reduces to the quartic Galileon Lagrangian when the
motion of the brane is non-relativistic and we show that it tends to violate
the null energy condition and to render cosmological fluctuations ghosts. There
nonetheless exists an interesting parameter space in which a stable phase of
quasi-exponential expansion can be achieved while the induced gravity leaves
non trivial imprints. We derive the exact second-order action governing the
dynamics of linear perturbations and we show that it can be simply understood
through a bimetric perspective. In the relativistic regime, we also calculate
the dominant contribution to the primordial bispectrum and demonstrate that
large non-Gaussianities of orthogonal shape can be generated, for the first
time in a concrete model. More generally, we find that the sign and the shape
of the bispectrum offer powerful diagnostics of the precise strength of the
induced gravity.Comment: 34 pages including 9 figures, plus appendices and bibliography.
Wordings changed and references added; matches version published in JCA
Reproducibility of differential proteomic technologies in CPTAC fractionated xenografts
The NCI Clinical Proteomic Tumor Analysis Consortium (CPTAC) employed a pair of reference xenograft proteomes for initial platform validation and ongoing quality control of its data collection for The Cancer Genome Atlas (TCGA) tumors. These two xenografts, representing basal and luminal-B human breast cancer, were fractionated and analyzed on six mass spectrometers in a total of 46 replicates divided between iTRAQ and label-free technologies, spanning a total of 1095 LC-MS/MS experiments. These data represent a unique opportunity to evaluate the stability of proteomic differentiation by mass spectrometry over many months of time for individual instruments or across instruments running dissimilar workflows. We evaluated iTRAQ reporter ions, label-free spectral counts, and label-free extracted ion chromatograms as strategies for data interpretation (source code is available from http://homepages.uc.edu/~wang2x7/Research.htm). From these assessments, we found that differential genes from a single replicate were confirmed by other replicates on the same instrument from 61 to 93% of the time. When comparing across different instruments and quantitative technologies, using multiple replicates, differential genes were reproduced by other data sets from 67 to 99% of the time. Projecting gene differences to biological pathways and networks increased the degree of similarity. These overlaps send an encouraging message about the maturity of technologies for proteomic differentiation
Emerging role of insulin with incretin therapies for management of type 2 diabetes
Type 2 diabetes mellitus (T2DM) is a progressive disease warranting intensification of treatment, as beta-cell function declines over time. Current treatment algorithms recommend metformin as the first-line agent, while advocating the addition of either basal-bolus or premixed insulin as the final level of intervention. Incretin therapy, including incretin mimetics or enhancers, are the latest group of drugs available for treatment of T2DM. These agents act through the incretin axis, are currently recommended as add-on agents either as second-or third-line treatment, without concurrent use of insulin. Given the novel role of incretin therapy in terms of reducing postprandial hyperglycemia, and favorable effects on weight with reduced incidence of hypoglycemia, we explore alternative options for incretin therapy in T2DM management. Furthermore, as some evidence alludes to incretins potentially increasing betacell mass and altering disease progression, we propose introducing these agents earlier in the treatment algorithm. In addition, we suggest the concurrent use of incretins with insulin, given the favorable effects especially in relation to weight gain
Feeding your Inflaton: Non-Gaussian Signatures of Interaction Structure
Primordial non-Gaussianity is generated by interactions of the inflaton
field, either self-interactions or couplings to other sectors. These two
physically different mechanisms can lead to nearly indistinguishable bispectra
of the equilateral type, but generate distinct patterns in the relative scaling
of higher order moments. We illustrate these classes in a simple effective
field theory framework where the flatness of the inflaton potential is
protected by a softly broken shift symmetry. Since the distinctive difference
between the two classes of interactions is the scaling of the moments, we
investigate the implications for observables that depend on the series of
moments. We obtain analytic expressions for the Minkowski functionals and the
halo mass function for an arbitrary structure of moments, and use these to
demonstrate how different classes of interactions might be distinguished
observationally. Our analysis casts light on a number of theoretical issues, in
particular we clarify the difference between the physics that keeps the
distribution of fluctuations nearly Gaussian, and the physics that keeps the
calculation under control.Comment: 33 pages (plus appendices), 3 figures. V2: references added, some
minor clarifications. Accepted for publication in JCA
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