Long-Term Dynamics and the Orbital Inclinations of the Classical Kuiper Belt Objects

We numerically integrated the orbits of 1458 particles in the region of the classical Kuiper Belt (41 AU < a < 47 AU) to explore the role of dynamical instabilities in sculpting the inclination distribution of the classical Kuiper Belt Objects (KBOs). We find that the selective removal of low-inclination objects by overlapping secular resonances (nu_17 and nu_18) acts to raise the mean inclination of the surviving population of particles over 4 billion years of interactions with Jupiter, Saturn, Uranus and Neptune, though these long-term dynamical effects do not themselves appear to explain the discovery of KBOs with inclinations near 30 degrees. Our integrations also imply that after 3 billion years of interaction with the massive planets, high inclination KBOs more efficiently supply Neptune-encountering objects, the likely progenitors of short-period comets, Centaurs, and scattered KBOs. The secular resonances at low inclinations may indirectly cause this effect by weeding out objects unprotected by mean motion resonances during the first 3 billion years.Comment: 23 pages, including 10 figures. Accepted for publication in A

Payload deployment method and system

A method and apparatus for deploying the payload of space shuttle or the like is described. It is referred to as the Stabilized Payload Deployment System (SPDS). The payload is rotated about an axis outside of the payload but approximately longitudinally with the cargo bay of the shuttle craft. The payload may thus be rotated through ninety degrees. In this case, that is, in its rotated position, the payload may or may not have a small portion located within the cargo bay. Alternatively, the payload may be located completely outside of the bay. According to the apparatus two separable hinge-like devices connect at one longitudinal side or edge of the payload to respective ones of the payload trunnions at different longitudinally spaced locations along the length of the payload. Separation of the payload from the cargo bay is made by unlatching a latch and by the use of a repulsion spring at the position of each hinge-like device. Two four-link mechanisms allow movement between payload and bay. Such accommodative movement is required especially during launch when considerable vibration is encountered

A limit on the presence of Earth-mass planets around a Sun-like star

We present a combined analysis of all publicly available, visible HST observations of transits of the planet HD 209458b. We derive the times of transit, planet radius, inclination, period, and ephemeris. The transit times are then used to constrain the existence of secondary planets in the system. We show that planets near an Earth mass can be ruled out in low-order mean-motion resonance, while planets less than an Earth mass are ruled out in interior, 2:1 resonance. We also present a combined analysis of the transit times and 68 high precision radial velocity measurements of the system. These results are compared to theoretical predictions for the constraints that can be placed on secondary planets.Comment: Accepted for publication in MNRAS. 16 pages, 9 figure

The Short Rotation Period of Nereid

We determine the period, p = 11.52 \pm 0.14 h, and a light curve peak-to-peak amplitude, a = 0.029 \pm 0.003 magnitudes, of the Neptunian irregular satellite Nereid. If the light curve variation is due to albedo variations across the surface, rather than solely to the shape of Nereid variations, the rotation period would be a factor of two shorter. In either case, such a rotation period and light curve amplitude, together with Nereid's orbital period, p=360.14 days, imply that Nereid is almost certainly in a regular rotation state, rather than the chaotic rotation state suggested by Schaefer and Schaefer (1988,2000) and Dobrovolskis (1995). Assuming that Nereid is perfectly spherical, the albedo variation is 3% across the observed surface. Assuming a uniform geometric albedo, the observed cross sectional area varies by 3%. We caution that the lightcurve found in this paper only sets limits on the combination of albedo and physical irregularity and that we cannot determine the orientation of Nereid's spin axis from our data.Comment: Accepted by ApJ Letters, 11 pages (incl. 1 figure

Patient-initiated switching between private and public inpatient hospitalisation in Western Australia 1980 – 2001: An analysis using linked data

BACKGROUND: The aim of the study was to identify any distinct behavioural patterns in switching between public and privately insured payment classifications between successive episodes of inpatient care within Western Australia between 1980 and 2001 using a novel 'couplet' method of analysing longitudinal data. METHODS: The WA Data Linkage System was used to extract all hospital morbidity records from 1980 to 2001. For each individual, episodes of hospitalisation were paired into couplets, which were classified according to the sequential combination of public and privately insured episodes. Behavioural patterns were analysed using the mean intra-couplet interval and proportion of discordant couplets in each year. RESULTS: Discordant couplets were consistently associated with the longest intra-couplet intervals (ratio to the average annual mean interval being 1.35), while the shortest intra-couplet intervals were associated with public concordant couplets (0.5). Overall, privately insured patients were more likely to switch payment classification at their next admission compared with public patients (the average rate of loss across all age groups being 0.55% and 2.16% respectively). The rate of loss from the privately insured payment classification was inversely associated with time between episodes (2.49% for intervals of 0 to 13 years and 0.83% for intervals of 14 to 21 years). In all age groups, the average rate of loss from the privately insured payment classification was greater between 1981 and 1990 compared with that between 1991 and 2001 (3.45% and 3.10% per year respectively). CONCLUSION: A small but statistically significant reduction in rate of switching away from PHI over the latter period of observation indicated that health care policies encouraging uptake of PHI implemented in the 1990s by the federal government had some of their intended impact on behaviour

Development of a health care policy characterisation model based on use of private health insurance

OBJECTIVE: The aim of this study was to develop a policy characterisation process based on measuring shifts in use of private health insurance (PHI) immediately following implementation of changes in federal health care policy. METHOD: Population-based hospital morbidity data from 1980 to 2001 were used to produce trend lines in the annual proportions of public, privately insured and privately uninsured hospital separations in age-stratified subgroups. A policy characterisation model was developed using visual and statistical assessment of the trend lines associated with changes in federal health care policy. RESULTS: Of eight changes in federal health care policy, two (introduction of Medicare and Lifetime Health Cover) were directly associated with major changes in the trend lines; however, minor changes in trends were associated with several of the other federal policies. Three types of policy effects were characterised by our model: direction change, magnitude change and inhibition. Results from our model suggest that a policy of Lifetime Health Cover, with a sanction for late adoption of PHI, was immediately successful in changing the private: public mix. The desired effect of the 30% rebate was immediate only in the oldest age group (70+ years), however, introduction of the lifetime health cover and limitations in the model restricted the ability to determine whether or if the rebate had a delayed effect at younger ages. CONCLUSION: An outcome-based policy characterisation model is useful in evaluating immediate effects of changes in health care policy

Dynamically excited outer solar system objects in the Hubble Space Telescope archive

We present the faintest mid-ecliptic latitude survey in the second part of Hubble Space Telescope archival search for outer solar system bodies. We report the discovery of 28 new trans-Neptunian objects and one small centaur (R similar to 2 km) in the band 5°-20° off the ecliptic. The inclination distribution of these excited objects is consistent with the distribution derived from brighter ecliptic surveys. We suggest that the size and inclination distribution should be estimated consistently using suitable surveys with calibrated search algorithms and reliable orbital information

A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells.

The MST1R gene is overexpressed in pancreatic cancer producing elevated levels of the RON tyrosine kinase receptor protein. While mutations in MST1R are rare, alternative splice variants have been previously reported in epithelial cancers. We report the discovery of a novel RON isoform discovered in human pancreatic cancer. Partial splicing of exons 5 and 6 (P5P6) produces a RON isoform that lacks the first extracellular immunoglobulin-plexin-transcription domain. The splice variant is detected in 73% of xenografts derived from pancreatic adenocarcinoma patients and 71% of pancreatic cancer cell lines. Peptides specific to RON P5P6 detected in human pancreatic cancer specimens by mass spectrometry confirm translation of the protein isoform. The P5P6 isoform is found to be constitutively phosphorylated, present in the cytoplasm, and it traffics to the plasma membrane. Expression of P5P6 in immortalized human pancreatic duct epithelial (HPDE) cells activates downstream AKT, and in human pancreatic epithelial nestin-expressing cells, activates both the AKT and MAPK pathways. Inhibiting RON P5P6 in HPDE cells using a small molecule inhibitor BMS-777607 blocked constitutive activation and decreased AKT signaling. P5P6 transforms NIH3T3 cells and induces tumorigenicity in HPDE cells. Resultant HPDE-P5P6 tumors develop a dense stromal compartment similar to that seen in pancreatic cancer. In summary, we have identified a novel and constitutively active isoform of the RON tyrosine kinase receptor that has transforming activity and is expressed in human pancreatic cancer. These findings provide additional insight into the biology of the RON receptor in pancreatic cancer and are clinically relevant to the study of RON as a potential therapeutic target

Twenty-One New Light Curves of OGLE-TR-56b: New System Parameters and Limits on Timing Variations

Although OGLE-TR-56b was the second transiting exoplanet discovered, only one light curve, observed in 2006, has been published besides the discovery data. We present twenty-one light curves of nineteen different transits observed between July 2003 and July 2009 with the Magellan Telescopes and Gemini South. The combined analysis of the new light curves confirms a slightly inflated planetary radius relative to model predictions, with R_p = 1.378 +/- 0.090 R_J. However, the values found for the transit duration, semimajor axis, and inclination values differ significantly from the previous result, likely due to systematic errors. The new semimajor axis and inclination, a = 0.01942 +/- 0.00015 AU and i = 73.72 +/- 0.18 degrees, are smaller than previously reported, while the total duration, T_14 = 7931 +/- 38 s, is 18 minutes longer. The transit midtimes have errors from 23 s to several minutes, and no evidence is seen for transit midtime or duration variations. Similarly, no change is seen in the orbital period, implying a nominal stellar tidal decay factor of Q_* = 10^7, with a three-sigma lower limit of 10^5.7.Comment: 14 pages, 5 figures, accepted to Ap