Evaluation Lkw-Parkleitsystem BAB A45

Zwischen der Nachfrage nach Parkmöglichkeiten für Lkw an Autobahnen und dem Angebot besteht trotz der umfangreichen Erhöhung der Parkkapazitäten in den letzten Jahren ein erhebliches Defizit. Das Bundesverkehrsministerium will dieses Defizit neben dem Aus- und Neubau von Rastanlagen unter anderem durch den Einsatz von Parkleitsystemen reduzieren. Das vorliegende Forschungsprojekt widmet sich der Evaluation solcher Parkleitsysteme. Im Vorlauf zum Forschungsprojekt wurde ein Lkw-Parkleitsystem (PLS) für Rastanlagen an Bundesautobahnen entwickelt und in einem Testgebiet mit 4 Rastanlagen auf der BAB A45 aufgebaut. Primäres Ziel des PLS ist die Ermittlung und Kommunikation der freien Lkw-Parkstände auf Rastanlagen. Dazu wurden ein „Parkplatzdetektionssystem mit flächenhafter Erfassung“ und dynamische Anzeigetafeln eingesetzt. Zur Prüfung der Wirksamkeit des PLS wurden die Lkw-Routen im Testgebiet nach der Kennzeichenerfassungsmethode ermittelt. Die Messungen und Auswertungen umfassten zeitlich 7 Phasen, in denen unterschiedliche Informationsumfänge den auf der BAB A45 Richtung Gießen verkehrenden Lkw angeboten wurden. Zusätzlich wurde das PLS über eine Befragung der Lkw-Fahrerinnen und Fahrer bewertet. Die Auswertungen ergaben folgendes Bild: 1. Lkw-Fahrer, deren Lenkzeit zugunsten einer Ruhephase unterbrochen werden muss, sind an den Informationen des PLS über freie Parkstände in hohem Maße interessiert. Für die Entscheidung zugunsten eines Parkstandes zum Abhalten der Ruhephase sind die Informationen über freie Parkstände auf Grundlage der durchgeführten Befragung eine wichtige Hilfe. Durch die Messungen konnte diese Aussage allerdings nicht verifiziert werden. 2. Bei der Untersuchung des Parkplatzwahlverhaltens konnte trotz des geäußerten Interesses keine signifikante Veränderung beim Vergleich der Messphasen mit unterschiedlichem Informationsumfang des PLS nachgewiesen werden: Hohe Auslastungen in der PWC Pfingstweide und der PWC Stauferburg wurden nicht in nennenswertem Umfang abgebaut, freie Parkstände auf der T+R Langen-Bergheim wurden nicht genutzt. Auch ein Einfluss des PLS auf den Parksuchverkehr konnte nicht festgestellt werden. 3. Das Parkverhalten innerhalb der Rastanlagen wurde ebenfalls räumlich und zeitlich differenziert untersucht. Positiv zeigte sich hier die sortiertere Befüllung nach Einführung des PLS: Zuerst werden die StVO-Parkstände gefüllt, es folgt das geduldete Parken in Fahrgassen z.B. hinter den gefüllten Schrägparkständen und erst im Anschluss daran bei hohem Parkdruck auch behinderndes und gefährdendes Parken. Die zusätzliche Bereitstellung von Parkinformationen innerhalb der Rastanlagen hat diesen gewünschten Effekt weiter unterstützt. 4. Während der Messphasen entspannte sich der ursprünglich vorhandene Parkdruck aufgrund des Rückgangs des Lkw-Verkehrs. Neben der allgemeinen Verkehrsentwicklung spielte auch die Brückenproblematik auf der BAB A45 für den Rückgang eine Rolle. Daraus folgend war für Lkw-Fahrerinnen und Fahrer die Entscheidung zugunsten einer Rastanlage mit freien Parkständen weniger relevant. Im Rahmen der Untersuchungen wurden die folgenden offenen Fragestellungen zum Lkw-Parken erkannt • Analyse der Kapazität von Längsparkstreifen als dynamische Größe • Untersuchung des Zusammenspiels der unterschiedlichen Einflussfaktoren auf das Parkverhalten von Lkw-Fahrerinnen und Fahrern auf Rastanlagen • Weitere Analyse von kurzen Verweilzeiten auf Rastanlagen die nicht Teil des vorliegenden Forschungsvorhabens waren.Despite the continuous construction and enlargement of rest areas along the motorways in Germany, there has been a significant gap between the demand for truck parking and the supply. The German Federal Ministry of Transport wants to reduce this deficit not only by expanding and building new rest areas, but also with other measures such as the use of parking guidance systems. This research project is dedicated to the evaluation of parking guidance systems. In the run-up to the research project, a truck parking guidance system (PLS) for rest areas on federal motorways was developed and set up in a test area with 4 rest areas on the A45 motorway. The primary goal of the PLS is to determine and communicate free truck parking spaces at rest areas. For this purpose, a "parking detection system with area coverage" was used. To test the effectiveness of the PLS, the truck routes in the test area were determined using the number plate recognition method. The measurements and evaluations comprised 7 phases in which different amounts of information were offered to the trucks traveling on the A45 motorway in the direction of Giessen. In addition, the PLS was evaluated via a survey of truck drivers. The evaluations produced the following picture: 1. Truck drivers whose driving time has to be interrupted in order to take a break are very interested in the information from the PLS about free parking spaces. The information on free parking spaces based on the survey carried out is an important aid for the decision in favor of a parking space for the rest period. However, this statement could not be verified by the measurements. 2. When examining the parking choice behavior, despite the interest expressed, no significant change could be detected when comparing the measurement phases with different amounts of information from the PLS: High occupancy rates in the rest areas PWC Pfingstweide and the PWC Stauferburg were not reduced to any significant extent, free parking spaces on the T+ R Langen-Bergheim were not used. An influence of the PLS on the parking search traffic could not be determined either. 3. The parking behavior within the rest areas was also examined in a spatially and temporally differentiated manner. The more sorted filling after the introduction of the PLS was positive here: First the legal parking spaces are filled, followed by tolerated parking in driving lanes, e.g. behind the filled inclined parking spaces, and only then with high parking pressure also obstructive and dangerous parking. The additional provision of parking information within the rest areas has further supported this desired effect. 4. During the measurement phases, the originally existing parking pressure relaxed due to the decrease in truck traffic. In addition to the general traffic development, the bridge problem on the BAB A45 also played a role in the decline. As a result, the decision in favor of a rest area with free parking spaces was less relevant for truck drivers. The following open questions about truck parking were identified as part of the investigations • Analysis of the capacity of parking lanes as a dynamic variable • Investigation of the interaction of the different influencing factors on the parking behavior of truck drivers at rest areas • Further analysis of short dwell times at rest areas which were not part of the present research project

Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154469/1/fsb2fj030708fje-sup-0001.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154469/2/fsb2fj030708fje.pd

Benefits and harms of perioperative high fraction inspired oxygen for surgical site infection prevention: a protocol for a systematic review and meta-analysis of individual patient data of randomised controlled trials.

INTRODUCTION The use of high fraction of inspired oxygen (FiO2) intraoperatively for the prevention of surgical site infection (SSI) remains controversial. Promising results of early randomised controlled trials (RCT) have been replicated with varying success and subsequent meta-analysis are equivocal. Recent advancements in perioperative care, including the increased use of laparoscopic surgery and pneumoperitoneum and shifts in fluid and temperature management, can affect peripheral oxygen delivery and may explain the inconsistency in reproducibility. However, the published data provides insufficient detail on the participant level to test these hypotheses. The purpose of this individual participant data meta-analysis is to assess the described benefits and harms of intraoperative high FiO2compared with regular (0.21-0.40) FiO2 and its potential effect modifiers. METHODS AND ANALYSIS Two reviewers will search medical databases and online trial registries, including MEDLINE, Embase, CENTRAL, CINAHL, ClinicalTrials.gov and WHO regional databases, for randomised and quasi-RCT comparing the effect of intraoperative high FiO2 (0.60-1.00) to regular FiO2 (0.21-0.40) on SSI within 90 days after surgery in adult patients. Secondary outcome will be all-cause mortality within the longest available follow-up. Investigators of the identified trials will be invited to collaborate. Data will be analysed with the one-step approach using the generalised linear mixed model framework and the statistical model appropriate for the type of outcome being analysed (logistic and cox regression, respectively), with a random treatment effect term to account for the clustering of patients within studies. The bias will be assessed using the Cochrane risk-of-bias tool for randomised trials V.2 and the certainty of evidence using Grading of Recommendations, Assessment, Development and Evaluation methodology. Prespecified subgroup analyses include use of mechanical ventilation, nitrous oxide, preoperative antibiotic prophylaxis, temperature (2.5 hour). ETHICS AND DISSEMINATION Ethics approval is not required. Investigators will deidentify individual participant data before it is shared. The results will be submitted to a peer-review journal. PROSPERO REGISTRATION NUMBER CRD42018090261

Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome.

Antiphospholipid syndrome (APS) is defined by recurrent pregnancy loss and thrombosis in the presence of antiphospholipid (aPL) Ab’s. Currently, therapy for pregnant women with APS is focused on preventing thrombosis, but anticoagulation is only partially successful in averting miscarriage. We hypothesized that complement activation is a central mechanism of pregnancy loss in APS and tested this in a model in which pregnant mice receive human IgG containing aPL Ab’s. Here we identify complement component C5 (and particularly its cleavage product C5a) and neutrophils as key mediators of fetal injury, and we show that Ab’s or peptides that block C5a–C5a receptor interactions prevent pregnancy complications. The fact that F(ab)′2 fragments of aPL Ab’s do not mediate fetal injury and that C4-deficient mice are protected from fetal injury suggests that activation of the complement cascade is initiated via the classical pathway. Studies in factor B–deficient mice, however, indicate that alternative pathway activation is required and amplifies complement activation. In contrast, activating FcγRs do not play an important role in mediating aPL Ab–induced fetal injury. Our findings identify the key innate immune effectors engaged by pathogenic autoantibodies that mediate poor pregnancy outcomes in APS and provide novel and important targets for prevention of pregnancy loss in APS

Climate mitigation and adaptation strategies in the transport sector: An empirical investigation in Germany

Due to climate change, extreme weather events will increase in intensity, frequency, and duration in the future, negatively impacting logistics and transport systems. The threat of missing climate targets and a lack of climate adaptivity strategies in the transport sector leads to growing climate-related risks for transportation companies. The present paper provides a qualitative study exploring mitigation and adaptation strategies within the logistics sector. It analyzes the challenges transportation companies face in developing climate-neutral business models and adapting to the consequences of climate change. Our results show that logistics companies need to be more prepared for the consequences of climate change and, at the same time, insufficiently address climate change mitigation, making the sector more vulnerable to climate extremes in the future. A transformation framework is developed to assess the logistics firms’ climate protection measures and climate adaptation strategies while highlighting existing development lags in climate mitigation and climate adaptation. Moreover, possible future strategies to combat climate risks in the sector are pathed

The effects of hyperbaric oxygenation on oxidative stress, inflammation and angiogenesis

Hyperbaric oxygen therapy (HBOT) is commonly used as treatment in several diseases, such as non-healing chronic wounds, late radiation injuries and carbon monoxide poisoning. Ongoing research into HBOT has shown that preconditioning for surgery is a potential new treatment application, which may reduce complication rates and hospital stay. In this review, the effect of HBOT on oxidative stress, inflammation and angiogenesis is investigated to better understand the potential mechanisms underlying preconditioning for surgery using HBOT. A systematic search was conducted to retrieve studies measuring markers of oxidative stress, inflammation, or angiogenesis in humans. Analysis of the included studies showed that HBOT-induced oxidative stress reduces the concentrations of pro-inflammatory acute phase proteins, interleukins and cytokines and increases growth factors and other pro-angiogenesis cytokines. Several articles only noted this surge after the first HBOT session or for a short duration after each session. The anti-inflammatory status following HBOT may be mediated by hyperoxia interfering with NF-κB and IκBα. Further research into the effect of HBOT on inflammation and angiogenesis is needed to determine the implications of these findings for clinical practice

The Effect of Hyperbaric Oxygen Therapy on Markers of Oxidative Stress and the Immune Response in Healthy Volunteers

Hyperbaric oxygen therapy (HBOT) consists of breathing 100% oxygen under increased ambient pressure. There are indications that HBOT induces oxidative stress and activates immune pathways. However, previous research on immunological effects of HBOT has mainly been established in in vitro experiments and selected patient populations, limiting generalizability and increasing the chances of confounding by comorbidities and specific patient-related factors. More insight into the immunological effects of HBOT would aid investigation and comprehension of potentially novel treatment applications. Therefore, in this study, we investigated the effects of three 110-min HBOT-sessions with 24-h intervals on immunological parameters in healthy, young, male volunteers. Blood samples were obtained before and after the first and third HBOT sessions. We assessed neutrophilic reactive oxygen species (ROS) production, systemic oxidative stress [plasma malondialdehyde (MDA) concentrations] as well as neutrophil phagocytic activity, plasma concentrations of tumor necrosis factor (TNF), interleukin (IL)-6, IL-8, and IL-10, and production of TNF, IL-6, and IL-10 by leukocytes ex vivo stimulated with the Toll-like receptor (TLR) ligands lipopolysaccharide (TLR4) and Pam3Cys (TLR2). We observed decreased neutrophilic ROS production and phagocytosis following the second HBOT session, which persisted after the third session, but no alterations in MDA concentrations. Furthermore, plasma concentrations of the investigated cytokines were unaltered at all-time points, and ex vivo cytokine production was largely unaltered over time as well. These results indicate no induction of systemic oxidative stress or a systemic inflammatory response after repeated HBOT in healthy volunteers but may suggest exhaustion of ROS generation capacity and phagocytosis