Population characteristics of GMS and NBS subjects.

<p>Population characteristics of GMS and NBS subjects.</p

Colorado NBS Population: Absolute change and annual rate of change (percent predicted per year) in FEV₁ percent predicted from early childhood to adolescence by adolescent lung function quartile.

<p>Absolute change in FEV₁ was defined as mean FEV₁ percent predicted_{age 6–8} minus mean FEV₁ percent predicted_adolescent. Annual rate of change was defined as absolute change in FEV/ (mean age adolescent PFTs–mean age early childhood PFTs).</p

Colorado NBS population: Linear regression, association with mean adolescent FEV₁ percent predicted.

<p>Results of linear regression investigating association of early childhood events/exposures with mean adolescent FEV₁ percent predicted. All variables with p<0.05 are shown; the model was also adjusted for gender, age at diagnosis, number of respiratory cultures prior to age 6, and number of PFTs used to calculate early childhood FEV₁. Variables eliminated from the model included genotype (F508del homozygous yes/no), diagnosis by newborn screening, percentage of cultures positive for <i>S</i>. <i>aureus</i> prior to age 6, and number of measures included in BMI value.</p

Colorado NBS population characteristics by adolescent lung function quartile.

<p>Colorado NBS population characteristics by adolescent lung function quartile.</p

GMS population: Early childhood lung function by <i>Pa</i> status before age 6 and severe vs. mild lung disease in adolescence.

<p>Mean FEV₁ percent predicted at 6 to 8 years of age is plotted by classification of lung disease in adolescence (severe vs. mild) and <i>Pa</i> infectious status up to age 6 (ever vs. never culture positive for <i>Pa</i>).</p

Colorado NBS Population: Early childhood lung function by adolescent lung function quartile and early childhood <i>Pa</i> status.

<p>Early childhood lung function (mean FEV₁ at 6–8 years of age) by adolescent lung function quartile and early childhood <i>Pa</i> status (ever/never <i>Pa</i> positive before age 6). Subjects were first divided into even quartiles by adolescent lung function (n = 43 in each quartile), then further divided by <i>Pa</i> status in early childhood. Among <i>Pa</i> positive subjects, those in the lowest adolescent lung function quartile had significantly lower early childhood lung function compared to all other quartiles; differences in early childhood lung function among <i>Pa</i> negative subjects did not reach statistical significance. When comparing subjects within individual adolescent lung function quartiles, <i>Pa</i> positive subjects in the lowest adolescent lung function quartile had significantly lower early childhood lung function than <i>Pa</i> negative (p<0.001); otherwise there were no significant differences in early childhood lung function by <i>Pa</i> status within adolescent lung function quartiles.</p

Colorado NBS Population: Annual rate of change in FEV₁ percent predicted from childhood to adolescence by adolescent lung function quartile and <i>Pa</i> status before 6 years of age.

<p>Colorado NBS Population: Annual rate of change in FEV₁ percent predicted from childhood to adolescence by adolescent lung function quartile and <i>Pa</i> status before 6 years of age.</p