16 research outputs found

    Labour mobility in the Roman world: the case of the Spanish mines

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    This is the author accepted manuscript. The final version was published as a chapter in Tacoma L, DeLigt L (eds) Migration and Mobility in the Early Roman Empire, Leiden: Brill, 2016, 95-137Abstract not availabl

    Retail trade in the city of Rome

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    EThOS - Electronic Theses Online ServiceGBUnited Kingdo

    Design and synthesis of a screening library using the natural product scaffold 3-chloro-4-hydroxyphenylacetic acid

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    The fungal metabolite 3-chloro-4-hydroxyphenylacetic acid (1) was utilized in the generation of a unique drug-like screening library using parallel solution-phase synthesis. A 20-membered amide library (3–22) was generated by first converting 1 to methyl (3-chloro-4-hydroxyphenyl)acetate (2), then reacting this scaffold with a diverse series of primary amines via a solvent-free aminolysis procedure. The structures of the synthetic analogues (3–22) were elucidated by spectroscopic data analysis. The structures of compounds 8, 12, and 22 were confirmed by single X-ray crystallographic analysis. All compounds were evaluated for cytotoxicity against a human prostate cancer cell line (LNCaP) and for antiparasitic activity toward Trypanosoma brucei brucei and Plasmodium falciparum and showed no significant activity at 10 μM. The library was also tested for effects on the lipid content of LNCaP and PC-3 prostate cancer cells, and it was demonstrated that the fluorobenzyl analogues (12–14) significantly reduced cellular phospholipid and neutral lipid levels
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