16 research outputs found
Labour mobility in the Roman world: the case of the Spanish mines
This is the author accepted manuscript. The final version was published as a chapter in Tacoma L, DeLigt L (eds) Migration and Mobility in the Early Roman Empire, Leiden: Brill, 2016, 95-137Abstract not availabl
P. Bang, M. Ikeguchi and H. Ziche (Eds), Ancient Economies, Modern Methodologies: Archaeology, Comparative History, Models and Institutions. Bari: Edipuglia, 2006. Pp. 280, illus. ISBN 978-8-87228-488-9. €40.00.
SKELETONS AT WORK - A.-C. Gillis (ed.) Corps, travail et statut social. L'apport de la paléoanthropologie funéraire aux sciences historiques. Pp. 209, figs, ills, maps. Villeneuve d'Ascq: Presses Universitaires du Septentrion, 2014. Paper, €24. ISBN: 978-2-7574-0767-7.
ROMAN DIRT AND HYGIENE - (M.) Bradley (ed.) Rome, Pollution and Propriety. Dirt, Disease and Hygiene in the Eternal City from Antiquity to Modernity. Pp. xx + 320, ills, maps. Cambridge: Cambridge University Press, 2012. Cased, £60, US$99. ISBN: 978-1-107-01443-5.
Roman Finance - (D.) Jones The Bankers of Puteoli. Finance, Trade and Industry in the Roman World. Pp. 288, figs, ill, pls. Stroud: Tempus, 2006. Paper, £19.99. ISBN: 978-0-7524-3594-7.
The Roman Economy - (P.F.) Bang The Roman Bazaar: a Comparative Study of Trade and Markets in a Tributary Empire. Pp. xvi + 358, figs, ills, maps. Cambridge: Cambridge University Press, 2008. Cased, £55, US$110. ISBN: 978-0-521-85532-7.
ROMAN ECONOMICS - (P.) Temin The Roman Market Economy. Pp. xiv + 299, figs. Princeton and Oxford: Princeton University Press, 2013. Cased, £24.95, US$35. ISBN: 978-0-691-14768-0.
Design and synthesis of a screening library using the natural product scaffold 3-chloro-4-hydroxyphenylacetic acid
The fungal metabolite 3-chloro-4-hydroxyphenylacetic acid (1) was utilized in the generation of a unique drug-like screening library using parallel solution-phase synthesis. A 20-membered amide library (3–22) was generated by first converting 1 to methyl (3-chloro-4-hydroxyphenyl)acetate (2), then reacting this scaffold with a diverse series of primary amines via a solvent-free aminolysis procedure. The structures of the synthetic analogues (3–22) were elucidated by spectroscopic data analysis. The structures of compounds 8, 12, and 22 were confirmed by single X-ray crystallographic analysis. All compounds were evaluated for cytotoxicity against a human prostate cancer cell line (LNCaP) and for antiparasitic activity toward Trypanosoma brucei brucei and Plasmodium falciparum and showed no significant activity at 10 μM. The library was also tested for effects on the lipid content of LNCaP and PC-3 prostate cancer cells, and it was demonstrated that the fluorobenzyl analogues (12–14) significantly reduced cellular phospholipid and neutral lipid levels