Relatedness Measures to Aid the Transfer of Building Blocks among Multiple Tasks

Multitask Learning is a learning paradigm that deals with multiple different tasks in parallel and transfers knowledge among them. XOF, a Learning Classifier System using tree-based programs to encode building blocks (meta-features), constructs and collects features with rich discriminative information for classification tasks in an observed list. This paper seeks to facilitate the automation of feature transferring in between tasks by utilising the observed list. We hypothesise that the best discriminative features of a classification task carry its characteristics. Therefore, the relatedness between any two tasks can be estimated by comparing their most appropriate patterns. We propose a multiple-XOF system, called mXOF, that can dynamically adapt feature transfer among XOFs. This system utilises the observed list to estimate the task relatedness. This method enables the automation of transferring features. In terms of knowledge discovery, the resemblance estimation provides insightful relations among multiple data. We experimented mXOF on various scenarios, e.g. representative Hierarchical Boolean problems, classification of distinct classes in the UCI Zoo dataset, and unrelated tasks, to validate its abilities of automatic knowledge-transfer and estimating task relatedness. Results show that mXOF can estimate the relatedness reasonably between multiple tasks to aid the learning performance with the dynamic feature transferring.Comment: accepted by The Genetic and Evolutionary Computation Conference (GECCO 2020

The Monument Project (Si Monumentum Reqiuis Circumspice) Leonardo article

This paper describes the concepts, ideas, background and operations of The Monument Project (Si Monumentum Requiris Circumspice), a digital video installation that produces a continuous stream of weather-responsive panoramic images from the top of the Monument in the City of London. The work, which was commissioned by Julian Harrap Architects, was part of a £4.5 million refurbishment of the 17th-century landmark, designed by Sir Christopher Wren and Dr. Robert Hooke to commemorate the Great Fire of London in 1666

Navigating New Landscapes in Debtor Creditor Law: Select Provisions of the Missouri Commercial Receivership Act Compared to Federal Bankruptcy Law

Two momentous legislative overhauls dealing directly with debtor-creditor relations were enacted in the latter half of the 2010s. First, in 2016, the Missouri General Assembly enacted the Missouri Commercial Receivership Act. This act, signed into law by Governor Jeremiah “Jay” Nixon on July 13, 2016, constitutes a significant overhaul of Missouri’s statutory mechanism empowering the circuit courts of the state to appoint receivers for the collection and preservation of a financially distressed debtor enterprise’s assets. Prior to the enactment of Missouri Commercial Receivership Act, creditors, debtors, and interested third parties were guided only by three sparse statutory provisions dating to the 19th century and over 150 years’ worth of common law glosses from Missouri courts on the law of receivership

The programming of Laplace's equation for solution by iteration on Whirlwind I

Thesis (B.S.) Massachusetts Institute of Technology. Dept. of Physics, 1950.MIT copy bound with: Calibration and alignment of a soft x-ray spectograph / E. Michael Gyorgy. 1950.Bibliography: leaf 37.by John H. Holland.B.S

Runaway GC evolution in gerbil genomes

Recombination increases the local GC-content in genomic regions through GC-biased gene conversion (gBGC). The recent discovery of a large genomic region with extreme GC-content in the fat sand rat Psammomys obesus provides a model to study the effects of gBGC on chromosome evolution. Here, we compare the GC-content and GC-to-AT substitution patterns across protein-coding genes of four gerbil species and two murine rodents (mouse and rat). We find that the known high-GC region is present in all the gerbils, and is characterised by high substitution rates for all mutational categories (AT-to-GC, GC-to-AT and GC-conservative) both at synonymous and nonsynonymous sites. A higher AT-to-GC than GC-to-AT rate is consistent with the high GC-content. Additionally, we find more than 300 genes outside the known region with outlying values of AT-to-GC synonymous substitution rates in gerbils. Of these, over 30% are organised into at least 17 large clusters observable at the megabase-scale. The unusual GC-skewed substitution pattern suggests the evolution of genomic regions with very high recombination rates in the gerbil lineage, which can lead to a runaway increase in GC-content. Our results imply that rapid evolution of GC-content is possible in mammals, with gerbil species providing a powerful model to study the mechanisms of gBGC

Benthic Macroinvertebrates as Indexes of Water Quality in the Upper Cuyahoga River

Author Institution: Department of Biology and Center for Environmental Studies, The University of AkronThe upper Cuyahoga River in northeastern Ohio is the major source of domestic water for the City of Akron, an important recreational area, and a designated Ohio Scenic River. Indexes of water quality based on benthic invertebrate community composition indicate a wide range in water quality along the river, but overall water quality is relatively high compared to areas of the Cuyahoga River below Akron and to most nearby river systems. Highest quality areas are located in the most headwater region and in the lowermost region near Lake Rockwell. These areas are characterized by a large number of taxa (>50), moderate density of organisms (= 2,000/m2), high ratios of scraper-grazers to detritivores (>0.5), high ratios of amphipods to isopods, and less than 1% organic pollution-tolerant organisms. Moderate degradation of water quality due to organic sedimentation in these areas is indicated by large proportions of organic pollution-facultative organisms (27-66%), especially a great variety of chironomids. Lowest quality areas occur 1-2 km below waste water outfalls from small villages and below groups of rural streamside dwellings. These areas are characterized by up to 62% fewer species, very low ratios of amphipods to isopods (usually <2), and large proportions of organic pollution-facultative and tolerant organisms (43-95%), especially chironomids and oligochaetes

Effect of urinary pH and diatrizoate on Bence Jones protein nephrotoxicity in the rat

Effect of urinary pH and diatrizoate on Bence Jones protein nephrotoxicity in the rat. Both low urinary pH and radiocontrast agents may intensify myeloma nephrotoxicity. To study the effects of these factors, we determined inulin clearances (CIn) before and after infusions of human Bence Jones protein (BJP) in male Sprague-Dawley rats in a dose previously shown to be nephrotoxic. Rats that drank 0.15 M NaHCO3 for 48 hr before study had no change in CIn (+ 3 ± 20%) after BJP unlike those that drank 0.15 M NH4Cl (- 33 ± 14%, P < 0.05); urinary pH differed (7.6 ± 0.1 vs. 6.2 ± 0.1, P < 0.05), but urinary flow rates did not. The acidifying regimen was used in all subsequent groups. Infusion of diatrizoate (DTZ) after BJP produced a further decrease in CIn (- 85 ± 8%, P < 0.05). In contrast, infusion of albumin, which raised plasma protein concentration to that seen in BJP-infused rats, did not change CIn (+ 39 ± 17%). Infusion of beta-lactoglobulin also led to a greater decrease in CIn after DTZ (- 35 ± 9 vs. - 67 ± 8%, P < 0.05), but myoglobin did not (- 58 ± 7 vs. - 54 ± 12%). Urinary pH and flow rate did not differ between any DTZ-infused group and its appropriate control. These data suggest that aciduria independent of urinary flow rate increases the nephrotoxicity of BJP. In this setting, DTZ further intensifies the nephrotoxicity of BJP as well as some but not all filterable proteins.Effet du pH urinaire et du diatrizoate sur la néphrotoxicité de la protéine de Bence Jones chez le rat. Un pH urinaire bas et les produits de contraste peuvent accroître la néphrotoxité du myélome. Pour étudier les effets de ces facteurs, nous avons déterminé les clearances de l'inuline (CIn) avant et après perfusion de protéine de Bence Jones humaine (BJP) chez des rats mâles Sprague-Dawley à dose préalablement montrée néphrotoxique. Les rats qui buvaient 0,15 M NaHCO3 pendant 48 hr avant l'étude n'avaient pas de modification de CIn (+ 3 ± 20%) après BJP à la différence de ceux qui buvaient 0,15 M NH4Cl (- 33 ± 14%, P < 0,05); les pH urinaires différaient (7,6 ± 0,1 contre 6,2 ± 0,1, P < 0,05), mais non les débits urinaires. Le régime acidifiant a été utilisé chez tous les groupes ultérieurs. La perfusion de diatrizoate (DTZ) après BJP a entraîné une diminution supplémentaire de CIn (- 85 ± 8%, P < 0,05). A l'opposé une perfusion d'albumine, qui augmentait la protidémie à la valeur observée chez les rats perfusés avec BJP ne modifiait pas CIn (+ 39 ± 17%). Une perfusion de béta-lactoglobuline a également entraîné une plus forte baisse de CIn après DTZ (- 35 ± 9 contre - 67 ± 8%, P < 0,05), mais non de la myoglobine (- 58 ± 7 contre - 54 ± 12%). Le pH et le débit urinaires ne différaient pas entre aucun des groupes perfusés par le DTZ et leur contrôle approprié. Ces données suggèrent que l'acidurie, indépendamment du débit urinaire, augmente la néphrotoxicité de la BJP. Dans ce schéma, DTZ accentue encore la néphrotoxicité de la BJP, de même que certaines, mais non toutes les protéines filtrables

Killer-cell Immunoglobulin-like Receptor gene linkage and copy number variation analysis by droplet digital PCR.

The Killer-cell Immunoglobulin-like Receptor (KIR) gene complex has considerable biomedical importance. Patterns of polymorphism in the KIR region include variability in the gene content of haplotypes and diverse structural arrangements. Droplet digital PCR (ddPCR) was used to identify different haplotype motifs and to enumerate KIR copy number variants (CNVs). ddPCR detected a variety of KIR haplotype configurations in DNA from well-characterized cell lines. Mendelian segregation of ddPCR-estimated KIR2DL5 CNVs was observed in Gambian families and CNV typing of other KIRs was shown to be accurate when compared to an established quantitative PCR method