Characterization Of Pregnancy Induced Cardiac Hypertrophy In Rats

During pregnancy, an increase in blood volume occurs to compensate for fetal development, resulting in cardiac hypertrophy. For the majority of women, this physiological cardiac hypertrophy resolves following pregnancy. Prolonged cardiac hypertrophy can lead to heart failure. We propose that by studying the biochemical mechanisms that mediate healthy cardiac remodeling associated with pregnancy, we will gain a better understanding of mechanisms involved in pathological cardiac hypertrophy. To determine the biochemical changes that occur during pregnancy induced cardiac remodeling, we subjected rats to timed matings and collected morphological and biochemical data from not pregnant, 19 days pregnant, and 24 hours postpartum. The heart weights increased approximately 6% on the 19th day of pregnancy as compared to their non-pregnant littermates. Histological analysis confirmed an increase in cardiomyocyte size associated with the increase in heart size. Real-time PCR analysis revealed alterations in expression of some gene markers of hypertrophy during pregnancy and postpartum. Our data demonstrates pregnancy induced cardiac remodeling in the rat involves both morphological and biochemical changes

Stabilization of Plutonium in Subsursface Environments via Microbial Reduction and Biofilm Formation

Our work is towards mechanistically understanding interactions of unsaturated bacterial biofilms and their extracellular polymeric substances (EPS) with actinide metals and metal surrogates under vadose zone conditions. Because metal contaminants in the vadose zone co-occur with organic pollutants, some of our work has included experiments with organic pollutants

Quality improvement training for burn care in low-and middle-income countries: A pilot course for nurses

BackgroundThere is an urgent need to empower practitioners to undertake quality improvement (QI) projects in burn services in low-middle income countries (LMICs). We piloted a course aimed to equip nurses working in these environments with the knowledge and skills to undertake such projects.MethodsEight nurses from five burns services across Malawi and Ethiopia took part in this pilot course, which was evaluated using a range of methods, including interviews and focus group discussions.ResultsCourse evaluations reported that interactive activities were successful in supporting participants to devise QI projects. Appropriate online platforms were integral to creating a community of practice and maintaining engagement. Facilitators to a successful QI project were active individuals, supportive leadership, collaboration, effective knowledge sharing and demonstrable advantages of any proposed change. Barriers included: staff attitudes, poor leadership, negative culture towards training, resource limitations, staff rotation and poor access to information to guide practice.ConclusionsThe course demonstrated that by bringing nurses together, through interactive teaching and online forums, a supportive community of practice can be created. Future work will include investigating ways to scale up access to the course so staff can be supported to initiate and lead quality improvement in LMIC burn services

Challenges in Early Management of Children with ANSD: Analysis of the Timeline from Diagnosis to Intervention

It is estimated that 7 to 10% of children with permanent hearing loss have a diagnosis of auditory neuropathy spectrum disorder (ANSD). Due to the unique nature of this disorder, audiologic management of children with ANSD is particularly challenging. This study analyzed the timeline from diagnosis to intervention for a group of children with ANSD followed at UNC Hospitals. Implications for audiologic management are also considered

Modeling Physiological Processes That Relate Toxicant Exposure and Bacterial Population Dynamics

Quantifying effects of toxicant exposure on metabolic processes is crucial to predicting microbial growth patterns in different environments. Mechanistic models, such as those based on Dynamic Energy Budget (DEB) theory, can link physiological processes to microbial growth. Here we expand the DEB framework to include explicit consideration of the role of reactive oxygen species (ROS). Extensions considered are: (i) additional terms in the equation for the ‘‘hazard rate’’ that quantifies mortality risk ; (ii) a variable representing environmental degradation ; (iii) a mechanistic description of toxic effects linked to increase in ROS production and aging acceleration, and to non-competitive inhibition of transport channels ; (iv) a new representation of the ‘‘lag time’’ based on energy required for acclimation. We estimate model parameters using calibrated Pseudomonas aeruginosa optical density growth data for seven levels of cadmium exposure. The model reproduces growth patterns for all treatments with a single common parameter set, and bacterial growth for treatments of up to 150 mg(Cd)/L can be predicted reasonably well using parameters estimated from cadmium treatments of 20 mg(Cd)/L and lower. Our approach is an important step towards connecting levels of biological organization in ecotoxicology. The presented model reveals possible connections between processes that are not obvious from purely empirical considerations, enables validation and hypothesis testing by creating testable predictions, and identifies research required to further develop the theory

Stabilization of Plutonium in Subsursface Environments via Microbial Reduction and Biofilm Formation

Our work is towards mechanistically understanding interactions of unsaturated bacterial biofilms and their extracellular polymeric substances (EPS) with actinide metals and metal surrogates under vadose zone conditions. Because metal contaminants in the vadose zone co-occur with organic pollutants, some of our work has included experiments with organic pollutants

The Role of Alternative Testing Strategies in Environmental Risk Assessment of Engineered Nanomaterials

Within toxicology there is a pressure to find new test systems to replace, reduce and refine animal testing. In nanoecotoxicology this raises a number of questions

Attitudes Toward Breast Cancer Genetic Testing in Five Special Population Groups

Purpose: This study examined interest in and attitudes toward genetic testing in 5 different population groups. Methods: The survey included African American, Asian American, Latina, Native American, and Appalachian women with varying familial histories of breast cancer. A total of 49 women were interviewed in person. Descriptive and nonparametric statistical techniques were used to assess ethnic group differences. Results: Overall, interest in testing was high. All groups endorsed more benefits than risks. There were group differences regarding endorsement of specific benefits and risks: testing to “follow doctor recommendations” (p=0.017), “concern for effects on family” (p=0.044), “distrust of modern medicine” (p=0.036), “cost” (p=0.025), and “concerns about communication of results to others” (p=0.032). There was a significant inverse relationship between interest and genetic testing cost (p Conclusion: Cost may be an important barrier to obtaining genetic testing services, and participants would benefit by genetic counseling that incorporates the unique cultural values and beliefs of each group to create an individualized, culturally competent program. Further research about attitudes toward genetic testing is needed among Asian Americans, Native Americans, and Appalachians for whom data are severely lacking. Future study of the different Latina perceptions toward genetic testing are encouraged

“Save Our History!” Collaborating to Preserve the Past at UMass Boston

Sparked by the 50th anniversary of the founding of the University of Massachusetts Boston in June 1964, University Archives and Special Collections (UASC) staff in the Joseph P. Healey Library collaborated with departments across campus to carry out a wide range of initiatives, all focused on locating, accessioning, preserving, and sharing the physical evidence of the university’s history. This poster outlines the various collecting activities, outreach methods, digitization projects, and dogged detective work that resulted in the addition of more than 2,500 linear feet of unique historic materials to the University Archives, as well as a number of well-received public events and exhibitions