Salmonella immunization confers cross protection without confounding pre-harvest serologic monitoring

Food borne Salmonella Typhimurium is a valid concern for the global pork industry. An attenuated oral swine Salmonella Choleraesuis vaccine has proven to be an effective tool for the pre-harvest reduction of carrier rates for multiple Salmonella spp. Serum antibody assays are available to monitor exposure to wild-type Salmonella infection. This clinical study assessed protection induced by an attenuated oral Salmonella Choleraesuis vaccine against challenge infection with S. Typhimurium in swine. A serologic antibody assay was concurrently evaluated for its ability to differentiate vaccinated pigs from those challenged with Salmonella Typhimurium. Vaccination significantly improved clinical scores, pyrexia, and enteric lesion prevalence, while numerically improving average daily weight gain, and group body weight variation in comparison to unvaccinated/challenged pigs. Vaccination, while protecting pigs against disease, did not generate detectable serum antibodies prior to challenge. No vaccinated animals became seropositive prior to challenge, indicating that conventional ELISA tests could be used in vaccinated pigs to monitor wild-type exposure. Following challenge, there was no detectable difference between vaccinated/challenged and non-vaccinated/challenged animals. All strict control pigs remained serum antibody negative. These findings support the use of this vaccine to protect swine against S. Typhimurium, without confounding pre-harvest Salmonella serologic monitoring programs

Effects of motifs in music therapy on the attention of children with externalizing behavior problems

Recent studies highlight the role of attention (i.e., executive attention and joint attention) in the negative association between children’s externalizing behavior problems (EBPs) and self-regulation. In music therapy improvisation, “Motifs” represent a repeated and meaningful use of freely improvised or structured music. They have been reported to be effective in drawing attention toward joint musical engagement. This study aimed to examine the effects of clinically derived motifs on the attention of a child with EBPs. Video microanalysis of four therapy sessions was employed. Interaction segments with/without motifs were then selected for analysis: (a) Executive attention measurement: a two-way analysis of variance (ANOVA) was conducted to examine the effects of Motifs (Factor I) across sessions (Factor II) on the duration of interaction segments. (b) Joint attention measurement: another two-way ANOVA investigated the effects of these two factors on the duration of joint attentive responses in each segment. Results showed that (a) the segments with Motifs tended to decrease in duration throughout the sessions, while (b) these segments showed a significant increase in proportions of joint attentional responses. These findings suggest a positive effect of Motifs on enhancing efficiency of joint attention execution over time, indicating the child’s recognition of the Motifs through learning

Use of SC54 for the reduction of salmonella in swine

Infections caused by S. choleraesuis have significant economic impact on pork production in the United States (Wilcock and Schwartz 1992). An avirulent live culture vaccine has been described for the purpose of protecting pigs against infections caused by S. choleraesuis (Kramer, Roof et al. 1992) (Roof and Doitchinoff 1995). Other serotypes of Salmonella have been associated with infections in swine in the United States. These includeS. typhimurium and S. typhisuis (Wilcock and Schwartz 1992), S. heidelberg (Reed, Olander et al. 1985), and S. agona (Fernandez, Duhamel et al. 1993). Two experiments were conducted. Experiment number I was designed to determine the effect of an avirulent live culture vaccine (SC540, NOBL Laboratories, Inc.) in swine on an experimental infection of S. typhimurium. Experiment number 2 was designed to determine the effect of SC540 on Salmonella serogroups within a commercial swine farm

New monotonicity formulas for Ricci curvature and applications. I

Original manuscript November 21, 2011We prove three new monotonicity formulas for manifolds with a lower Ricci curvature bound and show that they are connected to rate of convergence to tangent cones. In fact, we show that the derivative of each of these three monotone quantities is bounded from below in terms of the Gromov–Hausdorff distance to the nearest cone. The monotonicity formulas are related to the classical Bishop–Gromov volume comparison theorem and Perelman’s celebrated monotonicity formula for the Ricci flow. We will explain the connection between all of these. Moreover, we show that these new monotonicity formulas are linked to a new sharp gradient estimate for the Green function that we prove. This is parallel to the fact that Perelman’s monotonicity is closely related to the sharp gradient estimate for the heat kernel of Li–Yau. In [CM4] one of the monotonicity formulas is used to show uniqueness of tangent cones with smooth cross-sections of Einstein manifolds. Finally, there are obvious parallelisms between our monotonicity and the positive mass theorem of Schoen–Yau and Witten.National Science Foundation (U.S.) (Grant DMS-11040934)National Science Foundation (U.S.). Focused Research Group (Grant DMS 0854774)National Science Foundation (U.S.) (Grant 0932078

Randomised controlled trial of improvisational music therapy's effectiveness for children with autism spectrum disorders (TIME-A): study protocol

<p>Abstract</p> <p>Background</p> <p>Previous research has suggested that music therapy may facilitate skills in areas typically affected by autism spectrum disorders such as social interaction and communication. However, generalisability of previous findings has been restricted, as studies were limited in either methodological accuracy or the clinical relevance of their approach. The aim of this study is to determine effects of improvisational music therapy on social communication skills of children with autism spectrum disorders. An additional aim of the study is to examine if variation in dose of treatment (i.e., number of music therapy sessions per week) affects outcome of therapy, and to determine cost-effectiveness.</p> <p>Methods/Design</p> <p>Children aged between 4;0 and 6;11 years who are diagnosed with autism spectrum disorder will be randomly assigned to one of three conditions. Parents of all participants will receive three sessions of parent counselling (at 0, 2, and 5 months). In addition, children randomised to the two intervention groups will be offered individual, improvisational music therapy over a period of five months, either one session (low-intensity) or three sessions (high-intensity) per week. Generalised effects of music therapy will be measured using standardised scales completed by blinded assessors (Autism Diagnostic Observation Schedule, ADOS) and parents (Social Responsiveness Scale, SRS) before and 2, 5, and 12 months after randomisation. Cost effectiveness will be calculated as man years. A group sequential design with first interim look at N = 235 will ensure both power and efficiency.</p> <p>Discussion</p> <p>Responding to the need for more rigorously designed trials examining the effectiveness of music therapy in autism spectrum disorders, this pragmatic trial sets out to generate findings that will be well generalisable to clinical practice. Addressing the issue of dose variation, this study's results will also provide information on the relevance of session frequency for therapy outcome.</p> <p>Trial Registration</p> <p>Current Controlled Trials <a href="http://www.controlled-trials.com/ISRCTN78923965">ISRCTN78923965</a>.</p

Observation of Hadronic W Decays in t-tbar Events with the Collider Detector at Fermilab

We observe hadronic W decays in t-tbar -> W (-> l nu) + >= 4 jet events using a 109 pb-1 data sample of p-pbar collisions at sqrt{s} = 1.8 TeV collected with the Collider Detector at Fermilab (CDF). A peak in the dijet invariant mass distribution is obtained that is consistent with W decay and inconsistent with the background prediction by 3.3 standard deviations. From this peak we measure the W mass to be 77.2 +- 4.6 (stat+syst) GeV/c^2. This result demonstrates the presence of two W bosons in t-tbar candidates in the W (-> l nu) + >= 4 jet channel.Comment: 20 pages, 4 figures, submitted to PR

Search for the Supersymmetric Partner of the Top-Quark in ppˉp \bar{p} Collisions at s=1.8TeV\sqrt{s} = 1.8 {\rm TeV}

We report on a search for the supersymmetric partner of the top quark (stop) produced in $t \bar{t}$ events using $110 {\rm pb}^{-1}$ of $p \bar{p}$ collisions at $\sqrt{s} = 1.8 {\rm TeV}$ recorded with the Collider Detector at Fermilab. In the case of a light stop squark, the decay of the top quark into stop plus the lightest supersymmetric particle (LSP) could have a significant branching ratio. The observed events are consistent with Standard Model $t \bar{t}$ production and decay. Hence, we set limits on the branching ratio of the top quark decaying into stop plus LSP, excluding branching ratios above 45% for a LSP mass up to 40 {\rm GeV/c}$^{2}$.Comment: 11 pages, 4 figure

Search for Narrow Diphoton Resonances and for gamma-gamma+W/Z Signatures in p\bar p Collisions at sqrt(s)=1.8 TeV

We present results of searches for diphoton resonances produced both inclusively and also in association with a vector boson (W or Z) using 100 pb^{-1} of p\bar p collisions using the CDF detector. We set upper limits on the product of cross section times branching ratio for both p\bar p\to\gamma\gamma + X and p\bar p\to\gamma\gamma + W/Z. Comparing the inclusive production to the expectations from heavy sgoldstinos we derive limits on the supersymmetry-breaking scale sqrt{F} in the TeV range, depending on the sgoldstino mass and the choice of other parameters. Also, using a NLO prediction for the associated production of a Higgs boson with a W or Z boson, we set an upper limit on the branching ratio for H\to\gamma\gamma. Finally, we set a lower limit on the mass of a `bosophilic' Higgs boson (e.g. one which couples only to \gamma, W, and Z$ bosons with standard model couplings) of 82 GeV/c^2 at 95% confidence level.Comment: 30 pages, 11 figure

Inclusive jet cross section in pˉp{\bar p p} collisions at s=1.8\sqrt{s}=1.8 TeV

The inclusive jet differential cross section has been measured for jet transverse energies, $E_T$, from 15 to 440 GeV, in the pseudorapidity region 0.1$\leq | \eta| \leq$0.7. The results are based on 19.5 pb$^{-1}$ of data collected by the CDF collaboration at the Fermilab Tevatron collider. The data are compared with QCD predictions for various sets of parton distribution functions. The cross section for jets with $E_T>200$ GeV is significantly higher than current predictions based on O($\alpha_s^3$) perturbative QCD calculations. Various possible explanations for the high-$E_T$ excess are discussed.Comment: 8 pages with 2 eps uu-encoded figures Submitted to Physical Review Letter

Search for charged Higgs decays of the top quark using hadronic tau decays

We present the result of a search for charged Higgs decays of the top quark, produced in $p\bar{p}$ collisions at $\surd s =$ 1.8 TeV. When the charged Higgs is heavy and decays to a tau lepton, which subsequently decays hadronically, the resulting events have a unique signature: large missing transverse energy and the low-charged-multiplicity tau. Data collected in the period 1992-1993 at the Collider Detector at Fermilab, corresponding to 18.7$\pm$0.7~pb$^{-1}$, exclude new regions of combined top quark and charged Higgs mass, in extensions to the standard model with two Higgs doublets.Comment: uuencoded, gzipped tar file of LaTeX and 6 Postscript figures; 11 pp; submitted to Phys. Rev.