333 research outputs found

    Mechanisms of B cell activation and lymphomagenesis

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    The financialization of Danish cooperatives and the debasement of a collective housing good

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    The article tells the story of Danish cooperative housing’s radical transformation from a collective housing good and commons to a financialized asset during the 2000s when neoliberal housing reforms were introduced and the mortgage finance market was deregulated. Processes of financialization of collectively owned housing have to be understood not only in relation to the dynamics of the surrounding housing market and political-economic changes but also to the communities and social relations that they presuppose and feed off, often in contradictory ways, as people are motivated by both solidarity and private interests. Housing cooperatives have existed as a form of collective housing throughout the 20th century, balanced, on the one hand, between the reproduction of kin, family and local communities and the common good and, on the other, between the market and the reproduction of the base for both families, local communities and the larger public sharing the housing commons. During the 2000s, processes of financialization brought the market and the cooperatives’ base so close together, primarily through new mortgaging opportunities, that families and communities have lost their savings and the base has been undermined, both in a material and an immaterial sense. </jats:p

    Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 1, a pharmacokinetic/pharmacodynamic comparison with paroxetine in healthy men

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    We compared the effect of vortioxetine, paroxetine and placebo after three days of dosing on sleep architecture. This was a randomised, double-blind, four-way crossover, placebo-controlled, multiple-dose study in 24 healthy young men. Subjects received 20mg vortioxetine, 40mg vortioxetine, 20mg paroxetine or placebo for three consecutive days in four different periods with at least three weeks between them. Polysomnography and blood sampling for pharmacokinetic analysis were performed on the pre-dose night and nights 1 and 3 of dosing in each period. Plasma concentrations of vortioxetine and paroxetine during the polysomnography measurement were used to estimate SERT occupancies using published relationships in healthy subjects. All three active treatments significantly increased REM onset latency and decreased time spent in REM sleep. In the pharmacokinetic/pharmacodynamics analysis significant relationships were found between REM onset latency and time spent in REM sleep and vortioxetine/paroxetine exposure. The relation between REM suppression parameters and SERT occupancy was significantly different between vortioxetine and paroxetine, despite the same SERT occupancy. This indicates that vortioxetine has a different clinical pharmacological profile from paroxetine, which may explain the differences in adverse effect profile of the two drugs, for instance the lower incidence of nausea, weight gain and sexual dysfunction with vortioxetine

    Accuracy in evaluation of view factors between small and far surfaces

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    The contribution describes an approach that can be used during evaluation of a view factor between complex emitter and planar absorber surfaces. Rather than sophisticated mathematical attitude, practical way is offered. The source surface is divided into smaller parts with same surface normal and using some minor assumptions, summary view factor is calculated. The contribution is aimed on an error that can be caused considering these assumptions and further on, on a case study (evaluation of a view factor between ceramic plaques source surface and a photometric sensor), real differences are shown

    On the relation between shape and downward radiation of overhead radiant heaters

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    The paper aims on evaluating and assessing of the influence of a shape of overhead luminous infrared heater’s burner on heat distribution to the ambient. These devices are mainly used for heating of industrial or other large space buildings. The contribution is based on comparison between the experimental results and created mathematical model. The latest experimental results show that the maximum of radiant intensity does not lay right below the radiant heater. Actually, there exists a ring of maximal values around heater’s midpoint axis. Results prove that instead of reflectors’ geometry, very complicated shape of gas luminous heater’s burner plays the most significant role in radiant heat transfer from the luminous heater. It was evaluated that the position of the radiant intensity maximum is around 10° from the radiating surface’s normal direction. All the findings can be summarized in conclusion that uniform distribution of radiant intensity required for thermal comfort of occupants can be maintained just by optimizing of the shape of radiant heater’s burner. Besides this conclusion, it is also apparent that adding the reflector actually increases summary radiant heat flux to the desired zone and therefore radiant efficiency increases. It is also clear that varying the reflector shape, different improvement of the efficiency can be expected

    Design optimization study for an infrared heater using CFD and sensitivity analysis

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    Sensitivity analysis (SA) has become a very popular technique for various application areas. However, not many studies concern SA using CFD (computational fluid dynamics). The main problem appears to be the large number of model executions when using the Monte Carlo method of SA. The computing resources and time needed for such a SA in combination with CFD (in which one model execution could take several hours) can be enormous. Nevertheless, this paper describes an approach of using SA in such cases. The recommendations are obvious: simplifying the model as much as possible; considering just a key part of the model; and take more care about the speed of convergence. On this basis a case study on "Optimization of gas infrared heater radiation geometry" has been performed. The most interesting result is that the shape of the heater and the reflector material do not significantly influence the heat delivery to the occupied zone. The main conclusion is that Monte Carlo sensitivity analysis is not suitable for large CFD models with low level of abstraction. In order to obtain good results, we recommend to select a smaller part of the overall domain and/or to significantly simplify it

    Primary school students as co-researchers

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    Sexuality and Health: A Study of Tanzanian Men\'s Experiences of Living with HIV/AIDS

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    The aim of this study was to explore Tanzanian men\'s experiences regarding their health and sex life after they had been diagnosed with HIV. In-depth interviews were performed with a purposive sample of ten men living in an urban area in Tanzania and who had been HIV positive for more than one year. A phenomenological-hermeneutic approach was used for analyzing the transcribed interviews. Three themes emerged from the texts; “awareness of HIV infection”, “perceived and ideal health”, and “sex life a source of happiness and caring”. Living with HIV meant profound adjustments to daily life activities for the participants. HIV forced them to learn new ways of having sexual intercourse and new ways of acting as a man. The meaning of being a “real man” had changed from being a man with great sexual prowess to being a “caring man” within one elationship.Keywords: HIV; sex life; phenomenological-hermeneutic method; interviewsAfrican Journal of Reproductive Health Vol. 12 (1) 2008: pp. 35-4

    Why do they stay? A study of resilient child protection workers in three European countries

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    © 2017 Informa UK Limited, trading as Taylor & Francis Group. Whilst 50% of child protection workers across much of Europe and the affluent ‘West’ leave after two years, many stay and develop substantial professional careers. This paper discusses research in Italy, Sweden and England examining what factors explain ‘remaining’ for more than three years in this stressful job. Underpinned by a hermeneutic epistemology, qualitative interviews were undertaken and subject to an interpretative thematic analysis. The findings proved to be complex and multi-layered and this paper presents an overview of these. The theoretical framework for the project mainly drew on organisations and resilience, and the initial sections of the paper consider how formulations of resilience as contextual and relational can elucidate professional sustainability. Organisational issues are considered, including the impact of work management, of supervision and of allocation in different national contexts. The paper also focuses on the role of friendships and informal support at work. Threaded through these established themes are more, perhaps surprising, concepts: for example, creativity, power, reflexive spaces and interpersonal relations as explanatory of remaining in child protection work
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