Laser in the axial electric field as a tool to search for P-, T- invariance violation

We consider rotation of polarization plane of the laser light when a gas laser is placed in a longitudinal electric field (10~kV/cm). It is shown that residual anisotropy of the laser cavity 10^{-6} and the sensitivity to the angle of polarization plane rotation about 10^{-11} -10^{-12} rad allows one to measure an electron EDM with the sensitivity about 10^{-30} e cm.Comment: 12 page

Knocking down gene expression for growth hormone-releasing hormone inhibits proliferation of human cancer cell lines

Splice Variant 1 (SV-1) of growth hormone-releasing hormone (GHRH) receptor, found in a wide range of human cancers and established human cancer cell lines, is a functional receptor with ligand-dependent and independent activity. In the present study, we demonstrated by western blots the presence of the SV1 of GHRH receptor and the production of GHRH in MDA-MB-468, MDA-MB-435S and T47D human breast cancer cell lines, LNCaP prostate cancer cell line as well as in NCI H838 non-small cell lung carcinoma. We have also shown that GHRH produced in the conditioned media of these cell lines is biologically active. We then inhibited the intrinsic production of GHRH in these cancer cell lines using si-RNA, specially designed for human GHRH. The knocking down of the GHRH gene expression suppressed the proliferation of T47D, MDA-MB-435S, MDA-MB-468 breast cancer, LNCaP prostate cancer and NCI H838 non-SCLC cell lines in vitro. However, the replacement of the knocked down GHRH expression by exogenous GHRH (1–29)NH2 re-established the proliferation of the silenced cancer cell lines. Furthermore, the proliferation rate of untransfected cancer cell lines could be stimulated by GHRH (1–29)NH2 and inhibited by GHRH antagonists MZ-5-156, MZ-4-71 and JMR-132. These results extend previous findings on the critical function of GHRH in tumorigenesis and support the role of GHRH as a tumour growth factor

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Drei für Österreich neue Taxa der anökophytischen Gattung Bromus (Poaceae)

Scholz, H., Hohla, M. (2008): Drei für Österreich neue Taxa der anökophytischen Gattung Bromus (Poaceae). Linzer biologische Beiträge 40 (1): 279-286, DOI: http://doi.org/10.5281/zenodo.542752